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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2020

01-12-2020 | Anxiety | Research article

Psychopharmacological effects of riparin III from Aniba riparia (Nees) Mez. (Lauraceae) supported by metabolic approach and multivariate data analysis

Authors: Sócrates Golzio dos Santos, Isis Fernandes Gomes, Adriana Maria Fernandes de Oliveira Golzio, Augusto Lopes Souto, Marcus Tullius Scotti, Josean Fechine Tavares, Stanley Juan Chavez Gutierrez, Reinaldo Nóbrega de Almeida, José Maria Barbosa-Filho, Marcelo Sobral da Silva

Published in: BMC Complementary Medicine and Therapies | Issue 1/2020

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Abstract

Background

Currently there is a high prevalence of humor disorders such as anxiety and depression throughout the world, especially concerning advanced age patients. Aniba riparia (Nees) Mez. (Lauraceae), popular known as “louro”, can be found from the Amazon through Guianas until the Andes. Previous studies have already reported the isolation of alkamide-type alkaloids such as riparin III (O-methyl-N-2,6-dyhydroxy-benzoyl tyramine) which has demonstrated anxiolytic and antidepressant-like effects in high doses by intraperitoneal administration.

Methods

Experimental protocol was conducted in order to analyze the anxiolytic-like effect of riparin III at lower doses by intravenous administration to Wistar rats (Rattus norvegicus) (n = 5). The experimental approach was designed to last 15 days, divided in 3 distinct periods of five days: control, anxiogenic and treatment periods. The anxiolytic-like effect was evaluated by experimental behavior tests such as open field and elevated plus-maze test, combined with urine metabolic footprint analysis. The urine was collected daily and analyzed by 1H NMR. Generated data were statistically treated by Principal Component Analysis in order to detect patterns among the distinct periods evaluated as well as biomarkers responsible for its distinction.

Results

It was observed on treatment group that cortisol, biomarker related to physiological stress was reduced, indicating anxiolytic-like effect of riparin III, probably through activation of 5-HT2A receptors, which was corroborated by behavioral tests.

Conclusion

1H NMR urine metabolic footprint combined with multivariate data analysis have demonstrated to be an important diagnostic tool to prove the anxiolytic-like effect of riparin III in a more efficient and pragmatic way.
Literature
1.
Miladi-Gorji H, Rashidy-Pour A, Fathollahi Y. Anxiety profile in morphine-dependent and withdrawn rats: effect of voluntary exercise. Physiol Behav. 2012;105(2):195–202.PubMedCrossRef
2.
von Glischinski M, von Brachel R, Hirschfeld G. How depressed is “depressed”? A systematic review and diagnostic meta-analysis of optimal cut points for the Beck depression inventory revised (BDI-II). Qual Life Res. 2019;28(5):1111–8.CrossRef
3.
Li SYH, Bressington D. The effects of mindfulness-based stress reduction on depression, anxiety, and stress in older adults: a systematic review and meta-analysis. Int J Ment Health Nurs. 2019;28(3):635–56.PubMedCrossRef
4.
Kalandakanond-Thongsong S, Daendee S, Srikiatkhachorn A. Effect of the acute and chronic estrogen on anxiety in the elevated T-maze. Physiol Behav. 2012;105(2):357–63.PubMedCrossRef
5.
Pérez-Ortega G, Guevara-Fefer P, Chávez M, Herrera J, Martínez A, Martínez AL, et al. Sedative and anxiolytic efficacy of Tilia americana var. mexicana inflorescences used traditionally by communities of state of Michoacan, Mexico. J Ethnopharmacol. 2008;116(3):461–8.PubMedCrossRef
6.
Hennebelle T, Sahpaz S, Bailleul F. Plantes sédatives : évaluation pharmacologique et clinique. Médecine du Sommeil. 2007;4(13):4–14.CrossRef
7.
Wijeweera P, Arnason JT, Koszycki D, Merali Z. Evaluation of anxiolytic properties of Gotukola – (Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine. 2006;13(9–10):668–76.PubMedCrossRef
8.
Rabbani M, Sajjadi SE, Jafarian A, Vaseghi G. Anxiolytic effects of Salvia reuterana Boiss. On the elevated plus-maze model of anxiety in mice. J Ethnopharmacol. 2005;101(1–3):100–3.PubMedCrossRef
9.
Rock EM, Limebeer CL, Petrie GN, Williams LA, Mechoulam R, Parker LA. Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats. Psychopharmacology. 2017;234(14):2207–17.PubMedCrossRef
10.
Liu T, Ma Y, Zhang R, Zhong H, Wang L, Zhao J, et al. Resveratrol ameliorates estrogen deficiency-induced depression- and anxiety-like behaviors and hippocampal inflammation in mice. Psychopharmacology. 2019;236(4):1385–99.PubMedCrossRef
11.
Faustino TT, RBd A. Andreatini R. Plantas medicinais no tratamento do transtorno de ansiedade generalizada: uma revisão dos estudos clínicos controlados. Rev Bras Psiquiatr. 2010;32:429–36.PubMedCrossRef
12.
Barbosa-Filho JM, Yoshida M, Gottlieb O. The tyramines of Aniba riparia: transformation into models of natural products. Revista Latinoamericana de Química. 1990;21(1):5–7.
13.
Barbosa-Filho JM, Yoshida M, R. Gottlieb O, RdCSBC B, Giesbrecht AM, MCM Y. Benzoyl esters and amides, styrylpyrones and neolignans from the fruits of Aniba riparia. Phytochemistry. 1987;26(9):2615–7.CrossRef
14.
Melo CTV, Monteiro AP, Leite CP. Ara, uacute, jo FLOd, et al. anxiolytic-like effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in mice. Biol Pharm Bull. 2006;29(3):451–4.PubMedCrossRef
15.
Melo CTV, Monteiro AP, Leite CP, Araújo FLO, Lima VTM, Barbosa-Filho JM, et al. Anxiolytic-like effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in mice. Biol Pharm Bull. 2006;29(3):451–4.PubMedCrossRef
16.
Araújo FLO, Melo CTV, Rocha NFM, Moura BA, Leite CP, Amaral JF, et al. Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice. Naunyn Schmiedeberg's Arch Pharmacol. 2009;380(4):337–44.CrossRef
17.
Rios MY, Olivo HF. Chapter 3 - Natural and Synthetic Alkamides: Applications in Pain Therapy. In: Atta Ur R, editor. Studies in Natural Products Chemistry, vol. 43. Great Britain: Elsevier; 2014. p. 79–121.
18.
Sousa FCF, Monteiro AP, Melo CTV, Oliveira GR, Vasconcelos SMM, Fonteles MMF, et al. Antianxiety effects of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice. Phytother Res. 2005;19(12):1005–8.PubMedCrossRef
19.
Teixeira CPL, Melo CTV, Araújo FLO, Carvalho AMR, Silva MIG, Barbosa-Filho JM, et al. Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system. Fundam Clin Pharmacol. 2013;27(2):129–37.
20.
EJFd A, Rezende-Júnior LM, LKF L, MPd S-J, Silva OA, BPd SN, et al. Pathophysiological investigations, anxiolytic effects and interaction of a semisynthetic riparin with benzodiazepine receptors. Biomed Pharmacother. 2018;103:973–81.CrossRef
21.
Kim IY, Jung J, Jang M, Ahn YG, Shin JH, Choi JW, et al. 1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice. Biochem Biophys Res Commun. 2010;403(3–4):428–34.PubMedCrossRef
22.
Saude EJ, Skappak CD, Regush S, Cook K, Ben-Zvi A, Becker A, et al. Metabolomic profiling of asthma: Diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol. 2011;127(3):757–64.e6.PubMedCrossRef
23.
Moaddel R, Shardell M, Khadeer M, Lovett J, Kadriu B, Ravichandran S, et al. Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects. Psychopharmacology. 2018;235(10):3017–30.PubMedPubMedCentralCrossRef
24.
Zhu L, Liang Z-T, Yi T, Ma Y, Zhao Z-Z, Guo B-L, et al. Comparison of chemical profiles between the root and aerial parts from three Bupleurum species based on a UHPLC-QTOF-MS metabolomics approach. BMC Complement Altern Med. 2017;17(1):305.PubMedPubMedCentralCrossRef
25.
Nagana Gowda GA, Raftery D. Whole blood metabolomics by 1H NMR spectroscopy provides a new opportunity to evaluate coenzymes and antioxidants. Anal Chem. 2017;89(8):4620–7.PubMedCrossRef
26.
Al-Zuaidy MH, Mumtaz MW, Hamid AA, Ismail A, Mohamed S, Razis AFA. Biochemical characterization and 1H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats. BMC Complement Altern Med. 2017;17(1):359.PubMedPubMedCentralCrossRef
27.
Lee SY, Mediani A, Ismail IS, Maulidiani AF. Antioxidants and α-glucosidase inhibitors from Neptunia oleracea fractions using 1H NMR-based metabolomics approach and UHPLC-MS/MS analysis. BMC Complement Altern Med. 2019;19(1):7.PubMedPubMedCentralCrossRef
28.
Jankevics A, Liepinsh E, Liepinsh E, Vilskersts R, Grinberga S, Pugovics O, et al. Metabolomic studies of experimental diabetic urine samples by 1H NMR spectroscopy and LC/MS method. Chemom Intell Lab Syst. 2009;97(1):11–7.CrossRef
29.
Gowda GAN, Zhang S, Gu H, Asiago V, Shanaiah N, Raftery D. Metabolomics-based methods for early disease diagnostics. Expert Rev Mol Diagn. 2008;8(5):617–33.PubMedCrossRef
30.
Wold S, Esbensen K, Geladi P. Principal Component Analisis. Chemom Intell Lab Syst. 1987;2:37–52.CrossRef
31.
Yang Q, Xu L, Tang L-J, Yang J-T, Wu B-Q, Chen N, et al. Simultaneous detection of multiple inherited metabolic diseases using GC-MS urinary metabolomics by chemometrics multi-class classification strategies. Talanta. 2018;186:489–96.PubMedCrossRef
32.
Wojtowicz W, Zabek A, Deja S, Dawiskiba T, Pawelka D, Glod M, et al. Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases. Sci Rep. 2017;7(1):9108.PubMedPubMedCentralCrossRef
33.
Azam AA, Pariyani R, Ismail IS, Ismail A, Khatib A, Abas F, et al. Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats via 1H NMR spectroscopy. BMC Complement Altern Med. 2017;17(1):278.PubMedPubMedCentralCrossRef
34.
Barbosa-Filho JM. Silva ECd, Bhattacharyya J. synthesis of several new phenylethylamides of substituited benzoic acids. Quim Nova. 1990;13(4):332–4.
35.
Silvestre JS, Fernández AG, Palacios JM. Effects of rolipram on the elevated plus-maze test in rats: a preliminary study. J Psychopharmacol. 1999;13(3):274–7.PubMedCrossRef
36.
Aikey JL, Nyby JG, Anmuth DM, James PJ. Testosterone rapidly reduces anxiety in male house mice (Mus musculus). Horm Behav. 2002;42(4):448–60.PubMedCrossRef
37.
38.
Broadhurst PL. Determinants of emotionality in the rat: II. Strain differences. J Comp Physiol Psychol. 1958;51(1):55–9.PubMedCrossRef
39.
Natelson BH, Janocko L, Jacoby JH. An interaction between dietary tryptophan and stress in exacerbating gastric disease. Physiol Behav. 1981;26(2):197–200.PubMedCrossRef
40.
Schnorr CE, Morrone MDS, Weber MH, Lorenzi R, Behr GA, Moreira JCF. The effects of vitamin a supplementation to rats during gestation and lactation upon redox parameters: increased oxidative stress and redox modulation in mothers and their offspring. Food Chem Toxicol. 2011;49(10):2645–54.PubMedCrossRef
41.
Khasar SG, Dina OA, Green PG, Levine JD. Sound stress–induced Long-term enhancement of mechanical Hyperalgesia in rats is maintained by Sympathoadrenal Catecholamines. J Pain. 2009;10(10):1073–7.PubMedPubMedCentralCrossRef
42.
Dina OA, Levine JD, Green PG. Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress. Eur J Pain. 2011;15(8):796–800.PubMedPubMedCentralCrossRef
43.
de Paula SV, Vicente MA, Biojone C, Zangrossi H Jr, Guimarães FS, Joca SRL. Distinct behavioral consequences of stress models of depression in the elevated T-maze. Behav Brain Res. 2011;225(2):590–5.CrossRef
44.
Silva FC, Presgrave OAF. Manual de Utilização de Animais/FIOCRUZ. Rio de Janeiro: Fundação Oswaldo Cruz - FIOCRUZ; 2008.
45.
Damy SB, Camargo RS. Chammas R, Figueiredo LFPd. Aspectos fundamentais da experimentação animal - aplicações em cirurgia experimental. Revista da Associação Médica Brasileira. 2010;56:103–11.PubMedCrossRef
46.
Schmitt U, Hiemke C. Combination of open field and elevated plus-maze: a suitable test battery to assess strain as well as treatment differences in rat behavior. Prog Neuro-Psychopharmacol Biol Psychiatry. 1998;22(7):1197–215.CrossRef
47.
Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology. 1987;92(2):180–5.PubMedCrossRef
48.
Bradley BF, Starkey NJ, Brown SL, Lea RW. Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze. J Ethnopharmacol. 2007;111(3):517–25.PubMedCrossRef
49.
de Almeida RN, Motta SC, de Brito FC, Catallani B, Leite JR. Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats. Pharmacol Biochem Behav. 2004;77(2):361–4.PubMedCrossRef
50.
Hrubá L, Schutová B, Šlamberová R. Sex differences in anxiety-like behavior and locomotor activity following prenatal and postnatal methamphetamine exposure in adult rats. Physiol Behav. 2012;105(2):364–70.PubMedCrossRef
51.
Sun B, Li L, Wu S, Zhang Q, Li H, Chen H, et al. Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry. Anal Biochem. 2009;395(2):125–33.PubMedCrossRef
52.
Kim K-B, Um SY, Chung MW, Jung SC, Oh JS, Kim SH, et al. Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl2)-induced nephrotoxicity using proton nuclear magnetic resonance (1H NMR) in rats. Toxicol Appl Pharmacol. 2010;249(2):114–26.PubMedCrossRef
53.
Sheedy JR, Ebeling PR, Gooley PR, McConville MJ. A sample preparation protocol for 1H nuclear magnetic resonance studies of water-soluble metabolites in blood and urine. Anal Biochem. 2010;398(2):263–5.PubMedCrossRef
54.
Pellow S, Chopin P, File SE, Briley M. Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985;14(3):149–67.PubMedCrossRef
55.
McGuire J, Herman JP, Horn PS, Sallee FR, Sah R. Enhanced fear recall and emotional arousal in rats recovering from chronic variable stress. Physiol Behav. 2010;101(4):474–82.PubMedPubMedCentralCrossRef
56.
Morrow BA, George TP, Roth RH. Noradrenergic α-2 agonists have anxiolytic-like actions on stress-related behavior and mesoprefrontal dopamine biochemistry. Brain Res. 2004;1027(1–2):173–8.PubMedCrossRef
57.
58.
Calvez J, Fromentin G, Nadkarni N, Darcel N, Even P, Tomé D, et al. Inhibition of food intake induced by acute stress in rats is due to satiation effects. Physiol Behav. 2011;104(5):675–83.PubMedCrossRef
59.
Karim N, Irshad S, Khan I, Mohammad A, Anis I, Shah MR, et al. GABAA receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn). Pharmacol Biochem Behav. 2015;136:64–72.PubMedCrossRef
60.
Khan AW, Khan A-U, Ahmed T. anticonvulsant, anxiolytic, and sedative activities of Verbena officinalis. Front Pharmacol. 2016;7:499.PubMedPubMedCentral
61.
Sandoval-Herrera V, Trujillo-Ferrara JG, Miranda-Páez A, De La Cruz F, Zamudio SR. Corticosterone microinjected into nucleus pontis oralis increases tonic immobility in rats. Horm Behav. 2011;60(4):448–56.PubMedCrossRef
62.
Cannizzaro C, Plescia F, Gagliano M, Cannizzaro G, Mantia G, La Barbera M, et al. Perinatal exposure to 5-metoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat. Behav Brain Res. 2008;186(1):98–106.PubMedCrossRef
63.
Corley MJ, Caruso MJ, Takahashi LK. Stress-induced enhancement of fear conditioning and sensitization facilitates extinction-resistant and habituation-resistant fear behaviors in a novel animal model of posttraumatic stress disorder. Physiol Behav. 2012;105(2):408–16.PubMedCrossRef
64.
Ferré P, Fernández-Teruel A, Escorihuela RM, Driscoll P, Corda MG, Giorgi O, et al. Behavior of the Roman/Verh high- and low-avoidance rat lines in anxiety tests: relationship with defecation and self-grooming. Physiol Behav. 1995;58(6):1209–13.PubMedCrossRef
65.
Hall CS. Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality. J Comp Psychol. 1934;18(3):385–403.CrossRef
66.
Febo M, Felix-Ortiz AC, Johnson TR. Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal rats. Brain Res 2010;1325(0):77–88.
67.
Rok-Bujko P, Krząścik P, Szyndler J, Kostowski W, Stefański R. The influence of neonatal serotonin depletion on emotional and exploratory behaviours in rats. Behav Brain Res. 2012;226(1):87–95.PubMedCrossRef
68.
Salim S, Sarraj N, Taneja M, Saha K, Tejada-Simon MV, Chugh G. Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats. Behav Brain Res. 2010;208(2):545–52.PubMedCrossRef
69.
Douglas AJ, Johnstone LE, Leng G. Neuroendocrine mechanisms of change in food intake during pregnancy: a potential role for brain oxytocin. Physiol Behav. 2007;91(4):352–65.PubMedCrossRef
70.
Neuhäuser-Berthold M, Wirth S, Hellmann U, Bässler KH. Utilisation of N-acetyl-L-glutamine during long-term parenteral nutrition in growing rats: significance of glutamine for weight and nitrogen balance. Clin Nutr. 1988;7(3):145–50.CrossRef
71.
Holecek M, Kovarik M. Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet – effect of starvation. Food Chem Toxicol. 2011;49(12):3336–42.PubMedCrossRef
72.
Currie PJ, Khelemsky R, Rigsbee EM, Dono LM, Coiro CD, Chapman CD, et al. Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus. Behav Brain Res. 2012;226(1):96–105.PubMedCrossRef
73.
Ullrich PM, Lutgendorf SK, Kreder KJ. Physiologic reactivity to a laboratory stress task among men with benign prostatic hyperplasia. Urology. 2007;70(3):487–91.PubMedPubMedCentralCrossRef
74.
Sugaya K, Nishijima S, Miyazato M, Ogawa Y. Central nervous control of micturition and urine storage. J Smooth Muscle Res. 2005;41(3):117–32.PubMedCrossRef
75.
Kadekawa K, Nishijima S, Sugaya K, Miyazato M, Saito S. Mechanisms by which the serotonergic system inhibits micturition in rats. Life Sci. 2009;85(15–16):592–6.PubMedCrossRef
76.
Guy G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther. 1995;65(3):319–95.CrossRef
77.
Graeff FG, Viana MB, Mora PO. Dual role of 5-HT in defense and anxiety. Neurosci Biobehav Rev. 1997;21(6):791–9.PubMedCrossRef
78.
Boisvert JP, Boschuetz TJ, Resch JM, Mueller CR, Choi S. Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei. Neurosci Lett. 2011;498(3):213–7.PubMedPubMedCentralCrossRef
79.
Jung SY, Fraser MO, Ozawa H, Yokoyama O, Yoshiyama M, De Groat WC, et al. Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability. J Urol. 1999;162(1):204–12.PubMedCrossRef
80.
Zhou Y, Lu L, Li Z, Gao X, Tian J, Zhang L, et al. Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress. J Ethnopharmacol. 2011;137(1):236–44.PubMedCrossRef
81.
Kang S-M, Park J-C, Shin M-J, Lee H, Oh J, Ryu DH, et al. 1H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clin Biochem. 2011;44(4):293–9.PubMedCrossRef
82.
Ryan D, Robards K, Prenzler PD, Kendall M. Recent and potential developments in the analysis of urine: a review. Anal Chim Acta. 2011;684(1–2):17–29.CrossRef
83.
Jansen JJ, Hoefsloot HCJ, van der Greef J, Timmerman ME, Smilde AK. Multilevel component analysis of time-resolved metabolic fingerprinting data. Anal Chim Acta. 2005;530(2):173–83.CrossRef
84.
Jung J, Park M, Park HJ, Shim SB, Cho YH, Kim J, et al. 1H NMR-based metabolic profiling of naproxen-induced toxicity in rats. Toxicol Lett. 2011;200(1–2):1–7.PubMedCrossRef
85.
Ebbels TMD, Holmes E, Lindon JC, Nicholson JK. Evaluation of metabolic variation in normal rat strains from a statistical analysis of 1H NMR spectra of urine. J Pharm Biomed Anal. 2004;36(4):823–33.PubMedCrossRef
86.
Constantinou MA, Papakonstantinou E, Spraul M, Sevastiadou S, Costalos C, Koupparis MA, et al. 1H NMR-based metabonomics for the diagnosis of inborn errors of metabolism in urine. Anal Chim Acta. 2005;542(2):169–77.CrossRef
87.
Wang H-P, Liang Y-J, Zhang Q, Long D-X, Li W, Li L, et al. Changes in metabolic profiles of urine from rats following chronic exposure to anticholinesterase pesticides. Pestic Biochem Physiol. 2011;101(3):232–9.CrossRef
88.
Ernest LA. Physiological correlates of the forced swim test in rats. Physiol Behav. 1993;54(2):309–17.CrossRef
89.
Pinheiro-Mulder A, Aguila MB, Bregman R, Alberto M-d-L C. Exercise counters diet-induced obesity, proteinuria, and structural kidney alterations in rat. Pathol Res Pract. 2010;206(3):168–73.PubMedCrossRef
90.
Yankelevitch-Yahav R, Franko M, Huly A, Doron R. The forced swim test as a model of depressive-like behavior. J Vis Exp. 2015;97:52587.
91.
Muehlmann AM, Wilkinson JA, Devine DP. Individual differences in vulnerability for self-injurious behavior: studies using an animal model. Behav Brain Res. 2011;217(1):148–54.PubMedCrossRef
92.
Baumann MH, Williams Z, Zolkowska D, Rothman RB. Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat. Drug Alcohol Depend. 2011;114(2–3):147–52.PubMed
93.
Guarnieri G, Barazzoni R. Fighting protein-energy wasting in chronic kidney disease: a challenge of complexity. J Ren Nutr. 2011;21(1):2–6.PubMedCrossRef
94.
Andersen TB, Jødal L, Boegsted M, Erlandsen EJ, Morsing A, Frøkiær J, et al. GFR prediction from Cystatin C and Creatinine in children: effect of including body cell mass. Am J Kidney Dis. 2012;59(1):50–7.PubMedCrossRef
95.
Rossi L, Tirapegui J. Implicações do sistema serotoninérgico no exercício físico. Arq Bras Endocrinol Metabol. 2004;48:227–33.PubMedCrossRef
96.
Miyata S, Shimoi T, Hirano S, Yamada N, Hata Y, Yoshikawa N, et al. Effects of serotonergic anxiolytics on the freezing behavior in the elevated open-platform test in mice. J Pharmacol Sci. 2007;105(3):272–8.PubMedCrossRef
97.
Borsini F, Podhorna J, Marazziti D. Do animal models of anxiety predict anxiolytic-like effects of antidepressants? Psychopharmacology. 2002;163(2):121–41.PubMedCrossRef
98.
Rubio-Ruiz ME, Díaz-Díaz E, Cárdenas-León M, Argüelles-Medina R, Sánchez-Canales P, Larrea-Gallo F, et al. Glycation does not modify bovine serum albumin (BSA)-induced reduction of rat aortic relaxation: the response to glycated and nonglycated BSA is lost in metabolic syndrome. Glycobiology. 2008;18(7):517–25.PubMedPubMedCentralCrossRef
99.
Navab M, Smith JE, Goodman DS. Rat plasma prealbumin. Metabolic studies on effects of vitamin a status and on tissue distribution. J Biol Chem. 1977;252(14):5107–14.PubMed
100.
Saka B, Ozturk GB, Uzun S, Erten N, Genc S, Karan MA, et al. Nutritional risk in hospitalized patients: impact of nutritional status on serum prealbumin. Rev Nutr. 2011;24:89–98.CrossRef
101.
Beck FK, Rosenthal TC. Prealbumin: a marker for nutritional evaluation. Am Fam Physician. 2002;65(8):1575–83.PubMed
102.
Sousa FCF, Melo CTV, Monteiro AP, Lima VTM, Gutierrez SJC, Pereira BA, et al. Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice. Pharmacol Biochem Behav. 2004;78(1):27–33.PubMedCrossRef
103.
Fernandez SP, Gaspar P. Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion. Neuropharmacology. 2012;62(1):144–54.PubMedCrossRef
104.
Liu Y, Huang R, Liu L, Peng J, Xiao B, Yang J, et al. Metabonomics study of urine from Sprague–Dawley rats exposed to Huang-Yao-zi using 1H NMR spectroscopy. J Pharm Biomed Anal. 2010;52(1):136–41.PubMedCrossRef
105.
Folkedal O, Stien LH, Torgersen T, Oppedal F, Olsen RE, Fosseidengen JE, et al. Food anticipatory behaviour as an indicator of stress response and recovery in Atlantic salmon post-smolt after exposure to acute temperature fluctuation. Physiol Behav. 2012;105(2):350–6.PubMedCrossRef
Metadata
Title
Psychopharmacological effects of riparin III from Aniba riparia (Nees) Mez. (Lauraceae) supported by metabolic approach and multivariate data analysis
Authors
Sócrates Golzio dos Santos
Isis Fernandes Gomes
Adriana Maria Fernandes de Oliveira Golzio
Augusto Lopes Souto
Marcus Tullius Scotti
Josean Fechine Tavares
Stanley Juan Chavez Gutierrez
Reinaldo Nóbrega de Almeida
José Maria Barbosa-Filho
Marcelo Sobral da Silva
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Anxiety
Published in
BMC Complementary Medicine and Therapies / Issue 1/2020
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-020-02938-z

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