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Open Access 01-12-2022 | Anxiety Disorder | Research article

A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing

Authors: Pauline Hautekiet, Nelly D. Saenen, Dries S. Martens, Margot Debay, Johan Van der Heyden, Tim S. Nawrot, Eva M. De Clercq

Published in: BMC Medicine | Issue 1/2022

Abstract

Background

Studies often evaluate mental health and well-being in association with individual health behaviours although evaluating multiple health behaviours that co-occur in real life may reveal important insights into the overall association. Also, the underlying pathways of how lifestyle might affect our health are still under debate. Here, we studied the mediation of different health behaviours or lifestyle factors on mental health and its effect on core markers of ageing: telomere length (TL) and mitochondrial DNA content (mtDNAc).

Methods

In this study, 6054 adults from the 2018 Belgian Health Interview Survey (BHIS) were included. Mental health and well-being outcomes included psychological and severe psychological distress, vitality, life satisfaction, self-perceived health, depressive and generalised anxiety disorder and suicidal ideation. A lifestyle score integrating diet, physical activity, smoking status, alcohol consumption and BMI was created and validated. On a subset of 739 participants, leucocyte TL and mtDNAc were assessed using qPCR. Generalised linear mixed models were used while adjusting for a priori chosen covariates.

Results

The average age (SD) of the study population was 49.9 (17.5) years, and 48.8% were men. A one-point increment in the lifestyle score was associated with lower odds (ranging from 0.56 to 0.74) for all studied mental health outcomes and with a 1.74% (95% CI: 0.11, 3.40%) longer TL and 4.07% (95% CI: 2.01, 6.17%) higher mtDNAc. Psychological distress and suicidal ideation were associated with a lower mtDNAc of − 4.62% (95% CI: − 8.85, − 0.20%) and − 7.83% (95% CI: − 14.77, − 0.34%), respectively. No associations were found between mental health and TL.

Conclusions

In this large-scale study, we showed the positive association between a healthy lifestyle and both biological ageing and different dimensions of mental health and well-being. We also indicated that living a healthy lifestyle contributes to more favourable biological ageing.

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Title: A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing
Authors: Pauline Hautekiet
Nelly D. Saenen
Dries S. Martens
Margot Debay
Johan Van der Heyden
Tim S. Nawrot
Eva M. De Clercq
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Anxiety Disorder
Published in: BMC Medicine / Issue 1/2022
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-022-02524-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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