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Open Access 01-12-2016 | Case report

Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency

Authors: Andrea Artoni, Serena Maria Passamonti, Alberto Edefonti, Francesca Gianniello, Vittorio Civelli, Ida Martinelli

Published in: Italian Journal of Pediatrics | Issue 1/2016

Abstract

Background

Nephrotic syndrome confers an acquired prothrombotic phenotype due to the urinary loss of anticoagulant proteins.Patients with reactivation of nephrotic syndrome may develop thrombosis.

Case presentation

We report the case of a life-threatening cerebral venous thrombosis in a 13 year-old boy affected by a relapse of nephrotic syndrome during a P. aeruginosa otitis/mastoiditis. Due to the worsening general conditions and the severe neurological impairment, a course of systemic thrombolysis was successfully administered, followed by anticoagulant therapy. In the present case severe inherited thrombophilia (inherited dysfunctional protein S deficiency) was identified as an important additional risk factors for thrombosis.

Conclusions

A careful evalutaion of risk factos for thrombosi during reactivation of nephrotic syndrome include measurement of plasma anticaogulant proteins. When low, antithrombotic prophylaxis with heparin should be considered to prevent thrombotic episodes.

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Title: Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency
Authors: Andrea Artoni
Serena Maria Passamonti
Alberto Edefonti
Francesca Gianniello
Vittorio Civelli
Ida Martinelli
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-016-0227-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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