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BMC Medicine
Published in: BMC Medicine 1/2019

Open Access 01-12-2019 | Antipsychotics | Review

The effects of antipsychotic medications on microbiome and weight gain in children and adolescents

Authors: Tali Bretler, Hagar Weisberg, Omry Koren, Hadar Neuman

Published in: BMC Medicine | Issue 1/2019

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Abstract

Background

Atypical antipsychotics, also known as second-generation antipsychotics, are commonly prescribed as treatment for psychotic disorders in adults, as well as in children and adolescents with behavioral problems. However, in many cases, second-generation antipsychotics have unwanted side effects, such as weight gain, potentially further increasing risk for morbidities including obesity, diabetes, and cardiovascular disease. While various mechanisms for this weight gain have been proposed, including effects on metabolic hormone signaling, recent evidence points to the importance of the gut microbiome in this process. The microbial communities residing within the gut are affected by second-generation antipsychotics and can confer weight gain.

Main text

This review summarizes recent findings and presents data linking second-generation antipsychotics, gut microbiota alterations and weight gain. The review focuses on children and adolescent populations, which have not previously received much attention, but are of great interest because they may be most vulnerable to gut microbiome changes and may carry long-term metabolic effects into adulthood.

Conclusions

We present correlations between second-generation antipsychotics, gut microbiota alterations and weight gain, and suggest some mechanisms that may link them. A better understanding of the underlying mechanisms may lead to the design of improved treatments for psychotic disorders with fewer harmful side effects.
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Metadata
Title
The effects of antipsychotic medications on microbiome and weight gain in children and adolescents
Authors
Tali Bretler
Hagar Weisberg
Omry Koren
Hadar Neuman
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2019
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-019-1346-1

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