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Published in: BMC Medicine 1/2020

01-12-2020 | Antipsychotics | Commentary

Cardiovascular risk management in patients using antipsychotics: it is time to take action

Authors: Erik W. M. A. Bischoff, Kirsti M. Jakobs, Willem J. J. Assendelft

Published in: BMC Medicine | Issue 1/2020

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Excerpt

The study from Lai and colleagues, recently published in BMC Medicine, provides interesting new insights on sex-related associations between antipsychotic use and acute ischemic heart disease [1]. The authors demonstrated that antipsychotic use was associated with a 32% increased hazard rate of acute ischemic heart disease (IHD) among women (95% CI 1.05–1.67), but not among men. In their Hong Kong primary care population, almost 2% were prescribed antipsychotic drugs. …
Literature
1.
go back to reference Lai FTT, Guthrie B, Mercer SW, Smith DJ, Yip BHK, Chung GKK, et al. Association between antipsychotic use and acute ischemic heart disease in women but not in men: a retrospective cohort study of over one million primary care patients. BMC Med. 2020. https://doi.org/10.1186/s12916-020-01765-w. Lai FTT, Guthrie B, Mercer SW, Smith DJ, Yip BHK, Chung GKK, et al. Association between antipsychotic use and acute ischemic heart disease in women but not in men: a retrospective cohort study of over one million primary care patients. BMC Med. 2020. https://​doi.​org/​10.​1186/​s12916-020-01765-w.
2.
go back to reference Marston L, Nazareth I, Petersen I, Walters K, Osborn DP. Prescribing of antipsychotics in UK primary care: a cohort study. BMJ Open. 2014;4(12):e006135.CrossRefPubMedPubMedCentral Marston L, Nazareth I, Petersen I, Walters K, Osborn DP. Prescribing of antipsychotics in UK primary care: a cohort study. BMJ Open. 2014;4(12):e006135.CrossRefPubMedPubMedCentral
3.
go back to reference Correll CU, Solmi M, Veronese N, Bortolato B, Rosson S, Santonastaso P, et al. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry. 2017;16(2):163–80.CrossRefPubMedPubMedCentral Correll CU, Solmi M, Veronese N, Bortolato B, Rosson S, Santonastaso P, et al. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry. 2017;16(2):163–80.CrossRefPubMedPubMedCentral
4.
go back to reference (NICE) National Institute for Health and Care Excellence. Cardiovascular disease: risk assessment and reduction, including lipid modification. Clinical guideline [CG181] 2014 [updated September 2016. Available from: www.nice.org.uk/guidance/cg181. Accessed 28 Sept 2020. (NICE) National Institute for Health and Care Excellence. Cardiovascular disease: risk assessment and reduction, including lipid modification. Clinical guideline [CG181] 2014 [updated September 2016. Available from: www.​nice.​org.​uk/​guidance/​cg181. Accessed 28 Sept 2020.
5.
go back to reference Baller JB, McGinty EE, Azrin ST, Juliano-Bult D, Daumit GL. Screening for cardiovascular risk factors in adults with serious mental illness: a review of the evidence. BMC Psychiatry. 2015;15:55.CrossRefPubMedPubMedCentral Baller JB, McGinty EE, Azrin ST, Juliano-Bult D, Daumit GL. Screening for cardiovascular risk factors in adults with serious mental illness: a review of the evidence. BMC Psychiatry. 2015;15:55.CrossRefPubMedPubMedCentral
6.
go back to reference Jakobs KM, Posthuma A, de Grauw WJC, Schalk BWM, Akkermans RP, Lucassen P, et al. Cardiovascular risk screening of patients with serious mental illness or use of antipsychotics in family practice. BMC Fam Pract. 2020;21(1):153.CrossRefPubMedPubMedCentral Jakobs KM, Posthuma A, de Grauw WJC, Schalk BWM, Akkermans RP, Lucassen P, et al. Cardiovascular risk screening of patients with serious mental illness or use of antipsychotics in family practice. BMC Fam Pract. 2020;21(1):153.CrossRefPubMedPubMedCentral
7.
go back to reference Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, et al. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry. 2020;7(1):64–77.CrossRefPubMedPubMedCentral Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, et al. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry. 2020;7(1):64–77.CrossRefPubMedPubMedCentral
8.
go back to reference Gillies D, Buykx P, Parker AG, Hetrick SE. Consultation liaison in primary care for people with mental disorders. Cochrane Database Syst Rev. 2015;9:CD007193. Gillies D, Buykx P, Parker AG, Hetrick SE. Consultation liaison in primary care for people with mental disorders. Cochrane Database Syst Rev. 2015;9:CD007193.
9.
go back to reference Osborn D, Burton A, Hunter R, Marston L, Atkins L, Barnes T, et al. Clinical and cost-effectiveness of an intervention for reducing cholesterol and cardiovascular risk for people with severe mental illness in English primary care: a cluster randomised controlled trial. Lancet Psychiatry. 2018;5(2):145–54.CrossRefPubMed Osborn D, Burton A, Hunter R, Marston L, Atkins L, Barnes T, et al. Clinical and cost-effectiveness of an intervention for reducing cholesterol and cardiovascular risk for people with severe mental illness in English primary care: a cluster randomised controlled trial. Lancet Psychiatry. 2018;5(2):145–54.CrossRefPubMed
Metadata
Title
Cardiovascular risk management in patients using antipsychotics: it is time to take action
Authors
Erik W. M. A. Bischoff
Kirsti M. Jakobs
Willem J. J. Assendelft
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2020
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-020-01811-7

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