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11-11-2023 | Antiphospholipid Syndrome | Letters of Biomedical and Clinical Research

Pitfalls in antiphospholipid antibody testing: specifically interference from anticoagulation

Authors: Hammad Ali, Connor R. Buechler, Oneeb Sanaullah, Paramarajan Piranavan

Published in: Clinical Rheumatology | Issue 2/2024

Excerpt

Antiphospholipid syndrome (APS) is an autoimmune phenomenon defined by macrovascular and microvascular thrombotic events, non-thrombotic manifestations, and pregnancy morbidity in the presence of persistent evidence of antiphospholipid antibodies (aPL) [1]. aPL can be directed against phospholipids and/or phospholipid binding proteins, though only the latter have been shown to be pathogenic in APS [1]. Because the protean manifestations of APS can be attributed to a variety of alternative etiologies, APS is a disease defined in the laboratory. However, laboratory testing for aPL comes with many pitfalls, particularly with regard to the increasing number of patients on anticoagulant medications. …

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Devreese KMJ, de Groot PG, de Laat B et al (2020) Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: update of the guidelines for lupus anticoagulant detection and interpretation. J Thromb Haemost 18(11):2828–2839. https://doi.org/10.1111/jth.15047CrossRefPubMed

Vandevelde A, Devreese KMJ (2022) Laboratory diagnosis of antiphospholipid syndrome: insights and hindrances. J Clin Med. 11(8):2164. Published 2022 Apr 13. https://doi.org/10.3390/jcm11082164CrossRefPubMedPubMedCentral

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Ulcova-Gallova Z, Bibkova K, Micanova Z, Losan P, Babcova K (2015) Possible effect of extended use of hormonal contraception on increased levels of antiphospholipid antibodies in infertile women. Geburtshilfe Frauenheilkd. 75(3):251–254. https://doi.org/10.1055/s-0035-1545869 CrossRefPubMedPubMedCentral

11.

Ali H, Buechler CR, Sanaullah O, Lucas A, Lohr KL (2023) Iatrogenic ANA: an emerging source of expensive diagnostic confusion. Lupus 32(2):299–300. https://doi.org/10.1177/09612033221144600CrossRefPubMed

Title: Pitfalls in antiphospholipid antibody testing: specifically interference from anticoagulation
Authors: Hammad Ali
Connor R. Buechler
Oneeb Sanaullah
Paramarajan Piranavan
Publication date: 11-11-2023
Publisher: Springer International Publishing
Keywords: Antiphospholipid Syndrome
Antiphospholipid Syndrome
Anticoagulant
Heparin
Published in: Clinical Rheumatology / Issue 2/2024
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-023-06813-3

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