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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2015

Open Access 01-12-2015 | Research article

Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses

Authors: Mingshun Chen, Hecheng Meng, Yi Zhao, Fuquan Chen, Shujuan Yu

Published in: BMC Complementary Medicine and Therapies | Issue 1/2015

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Abstract

Background

In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM).

Methods

Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS.

Results

The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13 % against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry.

Conclusions

The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.
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Metadata
Title
Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses
Authors
Mingshun Chen
Hecheng Meng
Yi Zhao
Fuquan Chen
Shujuan Yu
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2015
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-015-0847-5

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