Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 11/2016

01-11-2016 | Rhinology

Antioxidant activities of curcumin in allergic rhinitis

Authors: Niyazi Altıntoprak, Murat Kar, Mustafa Acar, Mehmet Berkoz, Nuray Bayar Muluk, Cemal Cingi

Published in: European Archives of Oto-Rhino-Laryngology | Issue 11/2016

Login to get access

Abstract

We investigated the antioxidant effects of curcumin in an experimental rat model of allergic rhinitis (AR). Female Wistar albino rats (n = 34) were divided randomly into four groups: healthy rats (control group, n = 8), AR with no treatment (AR + NoTr group, n = 10), AR with azelastine HCl treatment (AR + Aze group, n = 8), and AR with curcumin treatment (AR + Curc group, n = 8). On day 28, total blood IgE levels were measured. For measurement of antioxidant activity, the glutathione (GSH) level and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities were measured in both inferior turbinate tissue and serum. Malondialdehyde (MDA) levels were measured only in inferior turbinate tissue, and paraoxonase (PON) and arylesterase (ARE) activities were measured only in serum. Statistically significant differences were found for all antioxidant measurements (GSH levels and CAT, SOD, GSH-Px activities in the serum and tissue, MDA levels in the tissue, and PON and ARE activities in the serum) between the four groups. In the curcumin group, serum SOD, ARE, and PON and tissue GSH values were higher than the control group. Moreover, tissue GSH levels and serum GSH-Px activities in the curcumin group were higher than in the AR + NoTr group. In the azelastine group, except MDA, antioxidant measurement values were lower than in the other groups. Curcumin may help to increase antioxidant enzymes and decrease oxidative stress in allergic rhinitis. We recommend curcumin to decrease oxidative stress in allergic rhinitis.
Literature
1.
2.
Srivastava RM, Singh S, Dubey SK, Misra K, Khar A (2011) Immunomodulatory and therapeutic activity of curcumin. Int Immunopharmacol 11:331–341CrossRefPubMed
3.
4.
Zaknun D, Schroecksnadel S, Kurz K, Fuchs D (2012) Potential role of antioxidant food supplements, preservatives and colorants in the pathogenesis of allergy and asthma. Int Arch Allergy Immunol 157(2):113–124CrossRefPubMed
5.
Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine, 4th edn. Clarendon, Oxford
6.
Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634–1658CrossRefPubMed
7.
8.
Jadhav NR, Powar T, Shinde S, Nadaf S (2014) Herbal nanoparticles: a patent review. Asian J Pharm 8:58–69CrossRef
9.
Kurup VP, Barrios CS (2008) Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res 52:1031–1039CrossRefPubMed
10.
Bahekar PC, Shah JH, Ayer UB, Mandhane SN, Thennati R (2008) Validation of guinea pig model of allergic rhinitis by oral and topical drugs. Int Immunopharmacol 8(11):1540–1551CrossRefPubMed
11.
Thakare VN, Osama MM, Naik SR (2013) Therapeutic potential of curcumin in experimentally induced allergic rhinitis in guinea pigs. Int Immunopharmacol 17(1):18–25CrossRefPubMed
12.
13.
An YF, Wang WH, Zhao CQ, Xue JM, Zhao HL (2007) Preliminary investigation into the allergic rhinitis complicated with acute bacterial sinusitis in mice. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:138–142PubMed
14.
Yagi K (1998) Simple procedure for specific enzyme of lipid hydroperoxides in serum or plasma. Methods Mol Biol 108:107–110PubMed
15.
16.
Sun Y, Oberley LW, Ying L (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34(3):497–500PubMed
17.
Eckerson HW, Romson J, Wyte C, La Du BN (1983) The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts. Am J Hum Genet 35(2):214–227PubMedPubMedCentral
18.
19.
Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR (1974) Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11(3):151–169CrossRefPubMed
20.
Jocelyn PC (1970) The function of subcellular fractions in the oxidation of glutathione in rat liver homogenate. Biochem J 117(5):951–956CrossRef
21.
Lowry OH, Rosebrough NI, Farr AL, Randall RJ (1961) Protein measurement with the Folin Phenol reagent. J Biol Chem 193:265–275
22.
Maiti M, Chattopadhyay K, Verma M, Chattopadhyay B (2015) Curcumin protects against nicotine-induced stress during protein malnutrition in female rat through immunomodulation with cellular amelioration. Mol Biol Rep 42(12):1623–1637CrossRefPubMed
23.
Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23:363–398PubMed
24.
Kalpana C, Sudheer AR, Rajasekharan KN, Menon VP (2007) Comparative effect of curcumin and its synthetic analogue lipid per oxidation on tissue and antioxidant status during nicotine induced toxicity. Singap Med J 48:124–130
25.
Shehzad A, Ha T, Subhan F, Lee YS (2011) New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr 50:151–161CrossRefPubMed
26.
Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB (2007) Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-jß-regulated gene products. Can Res 67:3853–3861CrossRef
27.
Kunnumakkara AB, Anand P, Aggarwal BB (2008) Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Can Lett 269:199–225CrossRef
28.
Karin M, Greten FR (2005) NF-κB linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5:749–759CrossRefPubMed
29.
Halliwell B (1999) Antioxidant defence mechanism: from the beginning to the end (of the beginning). Free Radic Res 31:261–272CrossRefPubMed
30.
Halliwell B, Rafter J, Jenner A (2005) Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct and indirect effects? Antioxidant or not? Am J Clin Nutr 81:268S–276SPubMed
31.
Siess H (1997) Oxidative stress: oxidants and antioxidants. Exp Physiol 82:291–295CrossRef
32.
Balsano C, Alisi A (2009) Antioxidant effects of natural bioactive compounds. Curr Pharm Des 15:3063–3073CrossRefPubMed
33.
Jenny M, Klieber M, Zaknun D, Schroecksnadel S, Kurz K, Ledochowski M et al (2010) In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors. Inflamm Res 60:127–135CrossRefPubMed
34.
Suzuki M, Nakamura T, Iyoki S, Fujiwara A, Watanabe Y, Mohri K, Isobe K et al (2005) Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull 28(8):1438–1443CrossRefPubMed
35.
Thakare VN, Osama M, Naik SR (2013) Therapeutic potential of curcumin in experimentally induced allergic rhinitis in guinea pigs. Int Immunopharmacol 17:18–25CrossRefPubMed
36.
Aggarwal BB, Harikumar KB (2009) Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41:40–59CrossRefPubMed
37.
Ide N, Lau BH (1997) Garlic compounds protect vascular endothelial cells from oxidized low-density lipoproteininduced injury. J Pharm Pharmacol 49:908–911CrossRefPubMed
38.
Ray B, Chauhan NB, Lahiri DK (2011) Oxidative insults to neurons and synapse are prevented by aged garlic extract and Sallyl-l-cysteine treatment in the neuronal culture and APPTg mouse model. J Neurochem 117:388–402CrossRefPubMedPubMedCentral
39.
Anoush M, Eghbal MA, Fathiazad F, Hamzeiy H, Kouzehkonani NS (2009) The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion. Pak J Biol Sci 12:765–771CrossRefPubMed
40.
Nahdi A, Hammami I, Kouidhi W, Chargui A, Ben Ammar A, Hamdaoui MH et al (2010) Protective effects of crude garlic by reducing iron-mediated oxidative stress, proliferation and autophagy in rats. J Mol Histol 41:233–245CrossRefPubMed
41.
Khanna NM (1999) Turmeric-nature’s precious gift. Curr Sci 76:1351–1356
42.
Zhang N, Li H, Jia J, He M (2015) Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse. Cell Immunol 298(1–2):88–95CrossRefPubMed
43.
Bishayee K, Khuda-Bukhsh AR (2013) 5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy. Acta Biochim Biophys Sin (Shanghai) 45(9):709–719CrossRef
44.
August EM, Nguyen T, Malinowski NM, Cysyk RL (1994) Non-steroidal anti-inflammatory drugs and tumor progression: inhibition of fibroblast hyaluronic acid production by indomethacin and mefenamic acid. Cancer Lett 82:49–54CrossRefPubMed
45.
Menon VP, Sudheer AR (2007) Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 595:105–125CrossRefPubMed
46.
Epstein J, Sanderson IR, Macdonald TT (2010) Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J Nutr 103(11):1545–1557CrossRefPubMed
47.
Thiyagarajan M, Sharma SS (2004) Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci 74(8):969–985CrossRefPubMed
48.
Yılmaz Savcun G, Ozkan E, Dulundu E, Topaloğlu U, Sehirli AO, Tok OE et al (2013) Antioxidant and anti-inflammatory effects of curcumin against hepatorenal oxidative injury in an experimental sepsis model in rats. Ulus Travma Acil Cerrahi Derg 19(6):507–515. doi:10.​5505/​tjtes.​2013.​76390 CrossRefPubMed
49.
Yarru LP, Settivari RS, Gowda NK, Antoniou E, Ledoux DR, Rottinghaus GE (2009) Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxin. Poult Sci 88:2620–2627CrossRefPubMed
50.
51.
52.
Thompson DA, Tan BB (2006) Tetrahydracurcumin-related allergic contact dermatitis. Contact Dermatitis 55:254–255CrossRefPubMed
53.
Lee JH, Kim JW, Ko NY, Mun SH, Her E, Kim BK et al (2008) Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the levelof Syk. J Allergy Clin Immunol 121(5):1225–1231CrossRefPubMed
Metadata
Title
Antioxidant activities of curcumin in allergic rhinitis
Authors
Niyazi Altıntoprak
Murat Kar
Mustafa Acar
Mehmet Berkoz
Nuray Bayar Muluk
Cemal Cingi
Publication date
01-11-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 11/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-4076-4

Other articles of this Issue 11/2016

European Archives of Oto-Rhino-Laryngology 11/2016 Go to the issue

Head and Neck

Critical analysis of anatomical landmarks within the sphenoid sinus for transsphenoidal surgery

Letter to the Editor

Reply to the letter to the editor by Beyan concerning: Increased mean platelet volume in patients with idiopathic subjective tinnitus

Letter to the Editor

Reply to the letter to the editor ‘‘in response to: a better design is needed for clinical studies of chronic tympanic membrane perforations using biological materials’’ 10.1007/s00405-016-4019-0

Review Article

The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans

Head and Neck

The role of prophylactic neck dissection and tumor thickness evaluation for patients with cN0 tongue squamous cell carcinoma

Review Article

Functional outcomes after supracricoid laryngectomy: what do we not know and what do we need to know?