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Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

Authors: Yasir Hasan Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal

Published in: Journal of Natural Medicines | Issue 1/2008

Abstract

Nordihydroguaiaretic acid (NDGA), a phenolic lignan, was tested for its antigenotoxic potential against chlormadinone acetate (CMA)-induced genotoxic damage in mice bone-marrow cells. Doses of about 22.50 mg/kg body weight of CMA were given along with 1, 5 and 10 mg/kg body weight of NDGA intraperitoneally. The treatment resulted in the reduction of sister chromatid exchanges and chromosomal aberrations induced by CMA, suggesting an antigenotoxic potential of NDGA. Earlier studies show that CMA generates reactive oxygen species, responsible for genotoxic damage. The free radical-scavenging property of NDGA is responsible for the reduction of genotoxic damage induced by CMA in mice bone-marrow cells.

Agarwal R, Wang ZY, Bik DP, Mukhtar H (1991) Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P450 mediated monoxygenase activity in rat epidermal and hepatic microsomes. Drug Metab Dispos 19:620–624PubMed

Capdevilla J, Gil L, Orellana M, Marnett IJ, Mason JL, Yadagiri P, Falck JR (1988) Inhibitors of cytochrome P450 dependent arachidonic acid metabolism. Arch Biochem Biophys 261:257–263CrossRef

Hurtado L, Hernández R, Hernandez F, Fernández F (1979) Fungitoxic compounds in the Larrea resin. In: Campos E, Mabri TJ, Fernández S (eds) Centro de investigación en quimica aplicada Larrea. Mexico, pp 328–340

Frasier L, Kehrer JP (1993) Effect of indomethacin, aspirin, nordihydroguaiaretic acid, and piperonyl butoxide on cyclophosphamide induced bladder damage. Drug Chem Toxicol 16:117–133PubMedCrossRef

Rothman SM, Yamada KA, Lancaster N (1993) Nordihydroguaiaretic acid attenuates NMDA neurotoxicity action beyond the receptor. Neuropharmacology 32:1279–1288PubMedCrossRef

Carlson JC, Sawada M, Boone DL, Stauffer JM (1995) Stimulation of progesterone secretion in dispersed cells of rat corpora lutea by antioxidants. Steroids 60:272–276PubMedCrossRef

Nagano N, Imaizumi Y, Hirano M, Watanabe M (1996) Opening of Ca²⁺-dependent K⁺ channels by nordihydroguaiaretic acid in porcine coronary arterial smooth muscle cells. Jpn J Pharmacol 70:281–284PubMed

Culver CA, Michalowski SM, Maia RC, Laster SM (2005) The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling. Life Sci 77:2457–2470PubMedCrossRef

Fujimoto N, Kohta R, Kitamura S, Honda H (2004) Estrogenic activity of an antioxidant, nordihydroguaiaretic acid (NDGA). Life Sci 74:1417–1425PubMedCrossRef

10.

Wang ZY, Agarwal R, Zbou ZC, Bickers DR (1991) Antimutagenic and antitumorigenic activities of nordihydroguaiaretic acid. Mutat Res 261:155–162

11.

Youngren JF, Gable K, Penaranda C, Maddux BA, Zavodorskaya M, Lobo M, Campbell M, Kerner J, Goldfine ID (2005) Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and C-erb B2/HER2/neu receptors and suppresses growth in breast cancer cells. Breast Cancer Res Treat 94:37–46PubMedCrossRef

12.

Madrigal-Bujaidar E, Díaz Barriga S, Cassani M, Molina D, Ponce G (1998) In vivo and in vitro induction of sister chromatid exchanges by nordihydroguaiaretic acid. Mutat Res 412:139–144PubMed

13.

Madrigal-Bujaidar E, Díaz Barriga S, Cassani M, Márquez P, Revuelta P (1998) In vivo and in vitro antigenotoxic effect of nordihydroguaiaretic acid against SCEs induced by methylmethane sulfonate. Mutat Res 419:163–168PubMed

14.

Siddique YH, Afzal M (2004) Evaluation of genotoxic potential of synthetic progestin chlormadinone acetate. Toxicol Lett 153:221–225PubMedCrossRef

15.

Siddique YH, Afzal M (2004) Induction of chromosomal aberrations and sister chromatid exchanges by chlormadinone acetate: a possible role of reactive oxygen species. Indian J Exp Biol 42:1078–1083PubMed

16.

Perry P, Wolff S (1974) New Giemsa method for differential staining of sister chromatids. Nature 251:156–158PubMedCrossRef

17.

Yosida TH, Amano K (1965) Autosomal polymorphism in laboratory bred and wild Norway rats. Rattus norvegicus Misima. Chromosoma 16:658–667PubMed

18.

IARC (1987) Progestins. In: International Agency for Research on Cancer (eds) Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1–42, vol 2. IARC, Lyon, pp 289–291

19.

Misdorp W (1991) Progestogens and mammary tumors in dogs and cats. Acta Endocrinol 125:27–31PubMed

20.

Martelli A, Campart GB, Ghia M, Allavena A, Merceto E, Brambilla G (1996) Induction of micronuclei and initiation of enzyme altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate or megestrol acetate. Carcinogenesis 17:551–554PubMedCrossRef

21.

Schuppler J, Gunzel P (1979) Liver tumors and steroid hormones in rats and mice. Arch Toxicol 2:181–165

22.

Yager JD, Yager R (1980) Oral contraceptives steroids as promoters of hepatocarcinogenesis in female Sprague–Dawley rats. Cancer Res 40:3680–3685PubMed

23.

Siddique YH, Beg T, Afzal M (2005) Antigenotoxic effects of ascorbic acid against megestrol acetate-induced genotoxicity in mice. Hum Exp Toxicol 24:121–127PubMedCrossRef

24.

Siddique YH, Afzal M (2005) Protective role of allicin and L-ascorbic acid against the genotoxic damage induced by chlormadinone acetate in cultured human lymphocytes. Indian J Exp Biol 43:769–772PubMed

25.

Siddique YH, Ara G, Beg T, Afzal M (2005) Protective role of natural plant products against estradiol-17β induced genotoxic damage. In: Recent Progress in Medicinal Plants. J. N. Govil (eds) vol 15. Sci. Tech. Publishing, LLC, Houston, Texas, USA, pp 415–429

26.

Siddique YH, Beg T, Afzal M (2006) Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage. Toxicol In Vitro 20:227–233PubMedCrossRef

27.

Ahmad MS, Sheeba, Afzal M (2004) Amelioration of genotoxic damage by certain phytoproducts in human lymphocyte cultures. Chem Biol Interact 150:107–115CrossRef

28.

Olivetto EP (1972) Nordihydroguaiaretic acid. A naturally occurring antioxidant. Chem Ind 2:677–679

29.

Floriano-Sanchez E, Villanueva C, Noel Medina-Campos O, Rocha D, Javier Sanchez-Gonzalez D, Cardenas-Rodriguez N, Pedraza-Chaverri J (2006) Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs. Free Radic Res 40:523–533PubMedCrossRef

30.

Dastur JF (1962) Medicinal plants of India and Pakistan. Taraporevala Sons, Bombay

31.

Swierenga SHH, Heddle JA, Sigal EA, Gilman JPW, Brillinger RL, Douglas GR, Nestmann ER (1991) Recommended protocols based on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberration and sister chromatid exchange in Chinese hamster ovary, V79 Chinese hamster lung and human lymphocyte cultures. Mutat Res 246:301–322PubMed

32.

IARC (1979) International Agency for Research on Cancer monograph on the evaluation of carcinogenic risk of chemicals to human sex hormones (II), vol 21. IARC, Lyon, pp 431–439

33.

El Etreby MF, Gräf KJ (1979) Effect of contraceptive steroids on mammary gland of beagle dog and its relevance to human carcinogenicity. Pharmacol Ther 5:369–402CrossRef

34.

Feser W, Kerdar RS, Bolde H, Reimann R (1996) Formation of DNA adducts by selected sex steroiods in rat liver. Hum Exp Toxicol 15:556–562PubMedCrossRef

35.

Werner S, Kuntz S, Beckurts T, Heidecke CD, Wolff T, Schwarz LR (1997) Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes. Mutat Res 395:179–187PubMed

36.

Topinka J, Binkova B, Zhu HK, Andrae U, Neumann I, Schwartz LR, Werner S, Wolff T (1995) DNA damaging activity of cyproterone acetate analogues of chlormadinone acetate and megestrol acetate in rat liver. Carcinogenesis 16:1483–1487PubMedCrossRef

37.

Vijayalaxmi KK, Venu R (1999) In vivo anticlastogenic effects of l-ascorbic acid in mice. Mutat Res 438:47–51PubMed

38.

Ghaskadbi S, Vaidya VG (1989) In vivo antimutagenic effect of ascorbic acid against the mutagenicity of the common anti-amoebic drug diiodohydroxy-quinoline. Mutat Res 222:219–222PubMedCrossRef

39.

Dearfield KL, Cimino MC, McCaroll NE, Mauer I, Valcovic LR (2002) Genotoxicity risk assessment: a proposed classification strategy. Mutat Res 521:121–135PubMed

Title: Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells
Authors: Yasir Hasan Siddique
Gulshan Ara
Tanveer Beg
Mohammad Afzal
Publication date: 01-01-2008
Publisher: Springer-Verlag
Published in: Journal of Natural Medicines / Issue 1/2008
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-006-0108-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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