Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Child's Nervous System
Published in: Child's Nervous System 12/2019

01-12-2019 | Antiepileptic Drugs | Original Article

Validation of the Azeri version of the Pediatric Epilepsy Side Effects Questionnaire

Authors: Salayev Kamran, Magalov Sharif, Garaybayli Garay

Published in: Child's Nervous System | Issue 12/2019

Login to get access

Abstract

Purpose

Long-lasting use of antiepileptic drugs in children with epilepsy negatively influences their quality of life and compliance. The purpose of this study was validation of the Azeri version of the Pediatric Epilepsy Side Effects Questionnaire (PESQ).

Methods

We collected the PESQ from caregivers of children with epilepsy. In order to screen for comorbid behavioral and emotional problems, the Strengths and Difficulties Questionnaire (SDQ) was used. Demographic and medical data were collected through patient charts. We conducted factor analysis and assessed internal consistency and construct validity of the PESQ.

Results

Caregivers of 120 patients with different epileptic syndromes completed the PESQ (age range 2–18; mean age 9.8 ± 4.0; male 56.7%; polytherapy 24%). The factor loading in the principal component analysis confirmed five-factor structure of the PESQ. The internal consistency coefficient of the total side effects scale of the PESQ was strong (0.86). Children receiving polytherapy showed higher scores on all subscales and the total score of the PESQ, supporting its construct validity. The total scores of the PESQ and the SDQ strongly correlated.

Conclusions

The PESQ can be used as a reliable and valid measure assessing antiepileptic drug side effects across the epilepsy spectrum.
Literature
1.
Modi AC, Ingerski LM, Rausch JR, Glauser TA (2011) Treatment factors affecting longitudinal quality of life in new onset pediatric epilepsy. J Pediatr Psychol 36:466–475CrossRef
2.
Giussani G, Bianchi E, Canelli V, Erba G, Franchi C, Nobili A, Sander JW, Beghi E, EPIRES Group (2017) Antiepileptic drug discontinuation by people with epilepsy in the general population. Epilepsia 58:1524–1532CrossRef
3.
Morita D, Glauser T, Modi A (2012) Development and validation of the Pediatric Epilepsy Side Effects Questionnaire. Neurology 79:1252–1258CrossRef
4.
Wu YP, Follansbee-Junger K, Rausch JR, Modi AC (2014) Parent and family stress factors predict health-related quality of life in pediatric patients with new-onset epilepsy. Epilepsia 55:866–877CrossRef
5.
Modi AC, Rausch JR, Glauser TA (2011) Patterns of non-adherence to antiepileptic drug therapy in children with newly diagnosed epilepsy. JAMA 305:1669–1676CrossRef
6.
Junger K, Morita D, Modi A (2015) The Pediatric Epilepsy Side Effects Questionnaire: establishing clinically meaningful change. Epilepsy Behav 45:101–104CrossRef
7.
Goodman R, Scott S (1999) Comparing the Strengths and Difficulties Questionnaire and the Child Behavior Checklist: is small beautiful? J Abnorm Child Psychol 27:17–24CrossRef
8.
Salayev K, Rustamov I, Gadjiyeva N, Salayev R, Sanne B (2016) The discriminative ability of the Azeri version of the strengths and difficulties questionnaire in outpatient practice. Community Ment Health J 52:1106–1112CrossRef
9.
Kim GH, Byeon JH, Eun SH, Eun BL (2015) Parents’ subjective assessment of effects of antiepileptic drug discontinuation. J Epilepsy Res 5:9–12CrossRef
10.
Carpay JA, Aldenkamp AP, van Donselaar CA (2005) Complaints associated with the use of antiepileptic drugs: results from a community-based study. Seizure 14:198–206CrossRef
11.
Dash D, Aggarwal V, Joshi R, Padma MV, Tripathi M (2015) Effect of reduction of antiepileptic drugs in patients with drug-refractory epilepsy. Seizure 27:25–29CrossRef
12.
Salayev KA, Sanne B, Salayev R (2017) Psychiatric and behavioural problems in children and adolescents with epilepsy. East Asian Arch Psychiatr 27:106–114
Metadata
Title
Validation of the Azeri version of the Pediatric Epilepsy Side Effects Questionnaire
Authors
Salayev Kamran
Magalov Sharif
Garaybayli Garay
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 12/2019
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-019-04287-w

Other articles of this Issue 12/2019

Child's Nervous System 12/2019 Go to the issue

Original Article

Pediatric peripheral nerve tumors: clinical and surgical aspects

Original Article

Childhood medulloblastoma—a single institution’s historical perspective on survival and functional morbidity

Letter to the Editor

An experimental challenge to bring the empirical study design a step closer to evidence-based medicine and quit ethically problematic situations

Original Article

Bedside placement of ventricular access devices under local anaesthesia in neonates with posthaemorrhagic hydrocephalus: preliminary experience

Letter to the Editor

Solitary tumefactive demyelinating pseudotumor masquerading as a low-grade glioma in a child

Case Report

Refractory epilepsy associated with ventriculoperitoneal shunt over-drainage: case report