Published in:
01-03-2020 | Antidepressant Drugs | Short Communication
Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model
Authors:
Lijia Chang, Kai Zhang, Yaoyu Pu, Youge Qu, Si-ming Wang, Zhongwei Xiong, Yukihiko Shirayama, Kenji Hashimoto
Published in:
European Archives of Psychiatry and Clinical Neuroscience
|
Issue 2/2020
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Abstract
It is reported that dopamine D1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. In the locomotion test, tail suspension test, forced swimming test and 1% sucrose preference test, pretreatment with dopamine D1 receptor antagonist SCH-23390 did not block the antidepressant effects of (R)-ketamine in the susceptible mice after chronic social defeat stress. These findings suggest that dopamine D1 receptors may not play a major role in the antidepressant actions of (R)-ketamine.