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Psychiatric Quarterly
Published in: Psychiatric Quarterly 3/2019

01-09-2019 | Antidepressant Drugs | Original Paper

Cognitive Impairments in First-Episode Drug-Naïve Versus Medicated Depressive Patients: RBANS in a Chinese Population

Authors: Qiu Fang Jia, Peng Chen, Hong Liang Zhu, Shan Shan Chen, Xiao Chu Gu, Xu Yuan Yin, Yan Hai Wu, Guang Zhong Yin, Li Hui

Published in: Psychiatric Quarterly | Issue 3/2019

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Abstract

Cognitive deficits are a core feature of major depressive disorder (MDD). However, there are no previous studies that directly compare cognitive performance between first-episode drug-naive depressive patients (FDDP) and medicated depressive patients (MDP). Therefore, the aim of this study was to investigate whether there were the differences in cognitive functions between FDDP and MDP. Sixty-two FDDP, 111 MDP and 90 healthy controls were enrolled in a Chinese population. Cognitive functions were assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). There were the differences in the RBANS total score (F = 26.55, p < 0.001), subscales of immediate memory (F = 3.95, p = 0.02), language (F = 54.11, p < 0.001) and delayed memory (F = 11.19, p = 0.001) among the three groups after controlling for gender, education, smoking and body mass index (BMI). These differences in the RBANS total score, subscales of language and delayed memory passed the Bonferroni corrections (all, p < 0.05). Compared to healthy controls, FDDP and MDP had poorer cognitive performance including the RBANS total score, and subscales of language and delayed memory (all, p < 0.05) after controlling for the variables. FDDP experienced greater language deficits than MDP (p < 0.05) after controlling for the variables. Education was correlated with the language score in FDDP (r = 0.61, p < 0.001). Multivariate regression analysis indicated that education was an independent contributor to the language score in FDDP (ß = 3.11, t = 5.48, p < 0.001). Our findings indicated that FDDP had poorer language performance than MDP. Moreover, education could influence the language performance in FDDP.
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Metadata
Title
Cognitive Impairments in First-Episode Drug-Naïve Versus Medicated Depressive Patients: RBANS in a Chinese Population
Authors
Qiu Fang Jia
Peng Chen
Hong Liang Zhu
Shan Shan Chen
Xiao Chu Gu
Xu Yuan Yin
Yan Hai Wu
Guang Zhong Yin
Li Hui
Publication date
01-09-2019
Publisher
Springer US
Published in
Psychiatric Quarterly / Issue 3/2019
Print ISSN: 0033-2720
Electronic ISSN: 1573-6709
DOI
https://doi.org/10.1007/s11126-019-09641-4

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