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Archives of Gynecology and Obstetrics

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01-12-2007 | Review Article

Anticoagulant therapy and thromboprophylaxis in patients with thrombophilia

Authors: Adi Y. Weintraub, Eyal Sheiner

Published in: Archives of Gynecology and Obstetrics | Issue 6/2007

Abstract

Objective

The aim of this review was to discuss the effectiveness of anticoagulant therapy and thromboprophylaxis in patients with thrombophilia.

Methods

A MEDLINE search was performed using the keywords: “anticoagulant therapy”, “pregnancy”, “thromboprophylaxis”, “thrombophilia”, “adverse pregnancy outcomes”, “venous thromboembolism”, “heparin” and “low molecular weight heparin”.

Results

The identification of a link between thrombophilic factors and adverse pregnancy outcome offers treatment possibilities. Until recently, it has not been clear whether antithrombotic therapy is useful in women with previous placental dysfunction and inherited thrombophilia. Anticoagulant therapy is indicated during pregnancy for the prevention and treatment of venous thromboembolism, for the prevention and treatment of systemic embolism in patients with mechanical heart valves and, for the prevention of pregnancy complications in women with antiphospholipid antibody syndrome or other thrombophilic disorders and previous pregnancy complications. At present, limited data exist regarding the efficacy of anticoagulants during pregnancy. Recommendations are largely based on data extrapolated from non-pregnant patients, case reports, and case series of pregnant patients. Many physicians have been treating such women with antithrombotic therapy on the basis of logic and anecdotal evidence.

Conclusion

A regimen for thrombophylaxis and treatment of thrombophilic parturient based on thrombophilia type is proposed.

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Title: Anticoagulant therapy and thromboprophylaxis in patients with thrombophilia
Authors: Adi Y. Weintraub
Eyal Sheiner
Publication date: 01-12-2007
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 6/2007
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-007-0409-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anticoagulant therapy and thromboprophylaxis in patients with thrombophilia

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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