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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 1/2020

01-01-2020 | Antibiotic | Inflammatory Disorders

Clinical and visual outcome of endophthalmitis patients: a single-center experience

Authors: Marcel Kitsche, Robert Herber, Lutz E. Pillunat, Naim Terai

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2020

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Abstract

Purpose

To report the clinical and visual outcome and the therapeutical management in a large cohort of endophthalmitis patients.

Methods

In a monocentric, observational study, we retrospectively analyzed the data of all patients with endophthalmitis who were referred to the department of ophthalmology of the Carl Gustav Carus Hospital Dresden between 2006 and 2018.

Results

In total, data of 104 patients (49 female, 55 male) were included in the present analysis. The most frequent clinical scenario for endophthalmitis was postcataract surgery (30.8%). The most frequent treatment at presentation was a pars plana vitrectomy (ppV) in 42 patients, followed by an intravitreal antibiotic in 41 patients. Out of 41 patients who received an intravitreal antibiotic, 35 patients (85%) needed additional treatment. In contrast, out of 42 patients who received a ppV as the initial treatment, 19 patients (42%) needed additional therapy, which was significantly different (p < 0.0001). The best presenting visual acuity improved significantly after treatment (p < 0.0001).

Conclusion

The results of the present study suggest that, compared with an intravitreal antibiotic, a ppV as the initial therapy of endophthalmitis might reduce the number of additional treatments. From our data, it can be hypothesized that a ppV should be performed as early as possible to achieve the best visual outcome in most endophthalmitis patients. Prospective studies are now needed to address this issue in greater detail and to confirm our findings.
Appendix
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Metadata
Title
Clinical and visual outcome of endophthalmitis patients: a single-center experience
Authors
Marcel Kitsche
Robert Herber
Lutz E. Pillunat
Naim Terai
Publication date
01-01-2020
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04480-2

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