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BMC Pediatrics

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Open Access 01-12-2021 | Antibiotic | Research article

Vancomycin-lock therapy for prevention of catheter-related bloodstream infection in very low body weight infants

Authors: Hong Liang, Lian Zhang, Xiaoping Guo, Li Sun

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

This study was to evaluate the effectiveness and safety of vancomycin- lock therapy for the prevention of catheter-related bloodstream infection (CRBSI) in very low body weight (VLBW) preterm infant patients.

Methods

One hundred and thirty-seven cases of VLBW preterm infants who retained peripherally inserted central catheters (PICCs) were retrospectively reviewed, including 68 treating with heparin plus vancomycin (vancomycin-lock group) and 69 with heparin only (control group). The incidence of CRBSI, related pathogenic bacteria, adverse events during the treatment, complications, antibiotic exposure, PICC usage time, hospital stay, etc. were compared between the above two groups.

Results

The incidence rate of CRBSI in the vancomycin-lock group (4.4%, 3/68) was significantly less than in the control group (21.7%, 15/69, p = 0.004). Total antibiotic exposure time during the whole observation period was significantly shorter in the group than in the control group (11.2 ± 10.0 vs 23.6 ± 16.1 d; p < 0.001). No hypoglycemia occurred during the locking, and the blood concentrations of vancomycin were not detectable.

Conclusions

Vancomycin-lock may effectively prevent CRBSI in Chinese VLBW preterm infants and reduce the exposure time of antibiotics, without causing obvious side complications.

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Title: Vancomycin-lock therapy for prevention of catheter-related bloodstream infection in very low body weight infants
Authors: Hong Liang
Lian Zhang
Xiaoping Guo
Li Sun
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Antibiotic
Vancomycin
Heparin
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-020-02482-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vancomycin-lock therapy for prevention of catheter-related bloodstream infection in very low body weight infants

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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