A technique for introducing broad-spectrum topical antibiotics during open reduction and internal fixation of acetabular fractures

go back to reference Li Q, Liu P, Wang G, Yang Y, Dong J, Wang Y, Zhou D (2015) Risk factors of surgical site infection after acetabular fracture surgery. Surg Infect (Larchmt) 16(5):577–582. https://doi.org/10.1089/sur.2014.134CrossRefPubMed Li Q, Liu P, Wang G, Yang Y, Dong J, Wang Y, Zhou D (2015) Risk factors of surgical site infection after acetabular fracture surgery. Surg Infect (Larchmt) 16(5):577–582. https://​doi.​org/​10.​1089/​sur.​2014.​134CrossRefPubMed

go back to reference Gillespie WJ, Walenkamp GH (2010) Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures. Cochrane Database Syst Rev 3:CD000244. https://doi.org/10.1002/14651858.CD000244.pub2CrossRef Gillespie WJ, Walenkamp GH (2010) Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures. Cochrane Database Syst Rev 3:CD000244. https://​doi.​org/​10.​1002/​14651858.​CD000244.​pub2CrossRef

go back to reference Toh CL, Jupiter JB (1995) The infected nonunion of the tibia. Clin Orthop Relat Res 315:176–191 Toh CL, Jupiter JB (1995) The infected nonunion of the tibia. Clin Orthop Relat Res 315:176–191

go back to reference Evans RP, Nelson CL, Harrison BH (1993) The effect of wound environment on the incidence of acute osteomyelitis. Clin Orthop Relat Res 286:289–297CrossRef Evans RP, Nelson CL, Harrison BH (1993) The effect of wound environment on the incidence of acute osteomyelitis. Clin Orthop Relat Res 286:289–297CrossRef

go back to reference O’Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Scharfstein DO, Gary JL, Bosse MJ, Castillo RC (2017) Local antibiotic therapy to reduce infection after operative treatment of fractures at high risk of infection: a multicenter, randomized, controlled trial (VANCO study). J Orthop Trauma 31(Suppl 1):S18–S24. https://doi.org/10.1097/BOT.0000000000000801CrossRef O’Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Scharfstein DO, Gary JL, Bosse MJ, Castillo RC (2017) Local antibiotic therapy to reduce infection after operative treatment of fractures at high risk of infection: a multicenter, randomized, controlled trial (VANCO study). J Orthop Trauma 31(Suppl 1):S18–S24. https://​doi.​org/​10.​1097/​BOT.​0000000000000801​CrossRef

go back to reference Ondeck NT, Ondeck MA, Bovonratwet P, Albert TJ, Grauer JN (2021) Local antibiotics in posterior lumbar fusion procedures for neuromuscular scoliosis: a case for their use. Spine J 21(4):664–670. https://doi.org/10.1016/j.spinee.2020.12.004CrossRefPubMed Ondeck NT, Ondeck MA, Bovonratwet P, Albert TJ, Grauer JN (2021) Local antibiotics in posterior lumbar fusion procedures for neuromuscular scoliosis: a case for their use. Spine J 21(4):664–670. https://​doi.​org/​10.​1016/​j.​spinee.​2020.​12.​004CrossRefPubMed

go back to reference Chiang HY, Herwaldt LA, Blevins AE, Cho E, Schweizer ML (2014) Effectiveness of local vancomycin powder to decrease surgical site infections: a meta-analysis. Spine J 14(3):397–407. https://doi.org/10.1016/j.spinee.2013.10.012CrossRefPubMed Chiang HY, Herwaldt LA, Blevins AE, Cho E, Schweizer ML (2014) Effectiveness of local vancomycin powder to decrease surgical site infections: a meta-analysis. Spine J 14(3):397–407. https://​doi.​org/​10.​1016/​j.​spinee.​2013.​10.​012CrossRefPubMed

go back to reference Evaniew N, Khan M, Drew B, Peterson D, Bhandari M, Ghert M (2015) Intrawound vancomycin to prevent infections after spine surgery: a systematic review and meta-analysis. Eur Spine J 24(3):533–542. https://doi.org/10.1007/s00586-014-3357-0CrossRefPubMed Evaniew N, Khan M, Drew B, Peterson D, Bhandari M, Ghert M (2015) Intrawound vancomycin to prevent infections after spine surgery: a systematic review and meta-analysis. Eur Spine J 24(3):533–542. https://​doi.​org/​10.​1007/​s00586-014-3357-0CrossRefPubMed

go back to reference Cichos KH, Spitler CA, Quade JH, Ponce BA, McGwin G Jr, Ghanem ES (2021) Intrawound antibiotic powder in acetabular fracture open reduction internal fixation does not reduce surgical site infections. J Orthop Trauma 35(4):198–204. https://doi.org/10.1097/BOT.0000000000001943CrossRefPubMed Cichos KH, Spitler CA, Quade JH, Ponce BA, McGwin G Jr, Ghanem ES (2021) Intrawound antibiotic powder in acetabular fracture open reduction internal fixation does not reduce surgical site infections. J Orthop Trauma 35(4):198–204. https://​doi.​org/​10.​1097/​BOT.​0000000000001943​CrossRefPubMed

go back to reference Owen MT, Keener EM, Hyde ZB, Crabtree RM, Hudson PW, Griffin RL, Lowe JA (2017) Intraoperative topical antibiotics for infection prophylaxis in pelvic and acetabular surgery. J Orthop Trauma 31(11):589–594. https://doi.org/10.1097/BOT.0000000000000941CrossRefPubMed Owen MT, Keener EM, Hyde ZB, Crabtree RM, Hudson PW, Griffin RL, Lowe JA (2017) Intraoperative topical antibiotics for infection prophylaxis in pelvic and acetabular surgery. J Orthop Trauma 31(11):589–594. https://​doi.​org/​10.​1097/​BOT.​0000000000000941​CrossRefPubMed

go back to reference O’Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Huang Y, Scharfstein DO, O’Hara NN, Gary JL, Bosse MJ, Castillo RC, Bishop JA, Weaver MJ, Firoozabadi R, Hsu JR, Karunakar MA, Seymour RB, Sims SH, Churchill C, Brennan ML, Gonzales G, Reilly RM, Zura RD, Howes CR, Mir HR, Wagstrom EA, Westberg J, Gaski GE, Kempton LB, Natoli RM, Sorkin AT, Virkus WW, Hill LC, Hymes RA, Holzman M, Malekzadeh AS, Schulman JE, Ramsey L, Cuff JAN, Haaser S, Osgood GM, Shafiq B, Laljani V, Lee OC, Krause PC, Rowe CJ, Hilliard CL, Morandi MM, Mullins A, Achor TS, Choo AM, Munz JW, Boutte SJ, Vallier HA, Breslin MA, Frisch HM, Kaufman AM, Large TM, LeCroy CM, Riggsbee C, Smith CS, Crickard CV, Phieffer LS, Sheridan E, Jones CB, Sietsema DL, Reid JS, Ringenbach K, Hayda R, Evans AR, Crisco MJ, Rivera JC, Osborn PM, Kimmel J, Stawicki SP, Nwachuku CO, Wojda TR, Rehman S, Donnelly JM, Caroom C, Jenkins MD, Boulton CL, Costales TG, LeBrun CT, Manson TT, Mascarenhas DC, Nascone JW, Pollak AN, Sciadini MF, Slobogean GP, Berger PZ, Connelly DW, Degani Y, Howe AL, Marinos DP, Montalvo RN, Reahl GB, Schoonover CD, Schroder LK, Vang S, Bergin PF, Graves ML, Russell GV, Spitler CA, Hydrick JM, Teague D, Ertl W, Hickerson LE, Moloney GB, Weinlein JC, Zelle BA, Agarwal A, Karia RA, Sathy AK, Au B, Maroto M, Sanders D, Higgins TF, Haller JM, Rothberg DL, Weiss DB, Yarboro SR, McVey ED, Lester-Ballard V, Goodspeed D, Lang GJ, Whiting PS, Siy AB, Obremskey WT, Jahangir AA, Attum B, Burgos EJ, Molina CS, Rodriguez-Buitrago A, Gajari V, Trochez KM, Halvorson JJ, Miller AN, Goodman JB, Holden MB, McAndrew CM, Gardner MJ, Ricci WM, Spraggs-Hughes A, Collins SC, Taylor TJ, Zadnik M (2021) Effect of intrawound vancomycin powder in operatively treated high-risk tibia fractures: a randomized clinical trial. JAMA Surg 156(5):e207259. https://doi.org/10.1001/jamasurg.2020.7259CrossRefPubMed O’Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Huang Y, Scharfstein DO, O’Hara NN, Gary JL, Bosse MJ, Castillo RC, Bishop JA, Weaver MJ, Firoozabadi R, Hsu JR, Karunakar MA, Seymour RB, Sims SH, Churchill C, Brennan ML, Gonzales G, Reilly RM, Zura RD, Howes CR, Mir HR, Wagstrom EA, Westberg J, Gaski GE, Kempton LB, Natoli RM, Sorkin AT, Virkus WW, Hill LC, Hymes RA, Holzman M, Malekzadeh AS, Schulman JE, Ramsey L, Cuff JAN, Haaser S, Osgood GM, Shafiq B, Laljani V, Lee OC, Krause PC, Rowe CJ, Hilliard CL, Morandi MM, Mullins A, Achor TS, Choo AM, Munz JW, Boutte SJ, Vallier HA, Breslin MA, Frisch HM, Kaufman AM, Large TM, LeCroy CM, Riggsbee C, Smith CS, Crickard CV, Phieffer LS, Sheridan E, Jones CB, Sietsema DL, Reid JS, Ringenbach K, Hayda R, Evans AR, Crisco MJ, Rivera JC, Osborn PM, Kimmel J, Stawicki SP, Nwachuku CO, Wojda TR, Rehman S, Donnelly JM, Caroom C, Jenkins MD, Boulton CL, Costales TG, LeBrun CT, Manson TT, Mascarenhas DC, Nascone JW, Pollak AN, Sciadini MF, Slobogean GP, Berger PZ, Connelly DW, Degani Y, Howe AL, Marinos DP, Montalvo RN, Reahl GB, Schoonover CD, Schroder LK, Vang S, Bergin PF, Graves ML, Russell GV, Spitler CA, Hydrick JM, Teague D, Ertl W, Hickerson LE, Moloney GB, Weinlein JC, Zelle BA, Agarwal A, Karia RA, Sathy AK, Au B, Maroto M, Sanders D, Higgins TF, Haller JM, Rothberg DL, Weiss DB, Yarboro SR, McVey ED, Lester-Ballard V, Goodspeed D, Lang GJ, Whiting PS, Siy AB, Obremskey WT, Jahangir AA, Attum B, Burgos EJ, Molina CS, Rodriguez-Buitrago A, Gajari V, Trochez KM, Halvorson JJ, Miller AN, Goodman JB, Holden MB, McAndrew CM, Gardner MJ, Ricci WM, Spraggs-Hughes A, Collins SC, Taylor TJ, Zadnik M (2021) Effect of intrawound vancomycin powder in operatively treated high-risk tibia fractures: a randomized clinical trial. JAMA Surg 156(5):e207259. https://​doi.​org/​10.​1001/​jamasurg.​2020.​7259CrossRefPubMed

go back to reference Balabanova A, Chu X, Chambers L, Mauffrey C, Parry JA (2021) Incidence of surgical site infections and acute kidney injuries after topical antibiotic powder application in orthopaedic trauma surgery. J Orthop Trauma 35(10):e377–e380. https://doi.org/10.1097/BOT.0000000000002071CrossRefPubMed Balabanova A, Chu X, Chambers L, Mauffrey C, Parry JA (2021) Incidence of surgical site infections and acute kidney injuries after topical antibiotic powder application in orthopaedic trauma surgery. J Orthop Trauma 35(10):e377–e380. https://​doi.​org/​10.​1097/​BOT.​0000000000002071​CrossRefPubMed

go back to reference O’Hara NN, Carullo J, Joshi M, Banoub M, Claeys KC, Sprague S, Slobogean GP, O’Toole RV, Investigators P-I (2022) Does cumulative topical antibiotic powder use increase the risk of drug induced acute kidney injury in fracture patients? Bone Jt Open 3(4):284–290. https://doi.org/10.1302/2633-1462.34.BJO-2022-0009.R1CrossRefPubMedPubMedCentral O’Hara NN, Carullo J, Joshi M, Banoub M, Claeys KC, Sprague S, Slobogean GP, O’Toole RV, Investigators P-I (2022) Does cumulative topical antibiotic powder use increase the risk of drug induced acute kidney injury in fracture patients? Bone Jt Open 3(4):284–290. https://​doi.​org/​10.​1302/​2633-1462.​34.​BJO-2022-0009.​R1CrossRefPubMedPubMedCentral

go back to reference Elhessy AH, Rivera JC, Shu HT, Andrews TJ, Herzenberg JE, Conway JD (2022) Intramedullary canal injection of vancomycin- and tobramycin-loaded calcium sulfate: a novel technique for the treatment of chronic intramedullary osteomyelitis. Strateg Trauma Limb Reconstr 17(2):123–130. https://doi.org/10.5005/jp-journals-10080-1554CrossRef Elhessy AH, Rivera JC, Shu HT, Andrews TJ, Herzenberg JE, Conway JD (2022) Intramedullary canal injection of vancomycin- and tobramycin-loaded calcium sulfate: a novel technique for the treatment of chronic intramedullary osteomyelitis. Strateg Trauma Limb Reconstr 17(2):123–130. https://​doi.​org/​10.​5005/​jp-journals-10080-1554CrossRef

go back to reference Keller DM, Pizzo RA, Patel JN, Viola A, Yoon RS, Liporace FA (2022) Use of antibiotic-cement coated locking plates in the setting of periprosthetic infection and infected nonunion. Injury 53(7):2567–2572. https://doi.org/10.1016/j.injury.2022.03.040CrossRefPubMed Keller DM, Pizzo RA, Patel JN, Viola A, Yoon RS, Liporace FA (2022) Use of antibiotic-cement coated locking plates in the setting of periprosthetic infection and infected nonunion. Injury 53(7):2567–2572. https://​doi.​org/​10.​1016/​j.​injury.​2022.​03.​040CrossRefPubMed

go back to reference Kirchner GJ, Smith NP, Garner MR (2021) Intra-wound vancomycin and tobramycin powder for infection prophylaxis in orthopaedic trauma surgery: economically justifiable? Injury 52(11):3340–3343. https://doi.org/10.1016/j.injury.2021.08.028CrossRefPubMed Kirchner GJ, Smith NP, Garner MR (2021) Intra-wound vancomycin and tobramycin powder for infection prophylaxis in orthopaedic trauma surgery: economically justifiable? Injury 52(11):3340–3343. https://​doi.​org/​10.​1016/​j.​injury.​2021.​08.​028CrossRefPubMed

go back to reference Firoozabadi R, Miranda S, Tornetta P 3rd (2017) Technique for placement of peri-implant antibiotics using antibiotic putty. J Orthop Trauma 31(12):e442–e445. https://doi.org/10.1097/BOT.0000000000000955CrossRefPubMed Firoozabadi R, Miranda S, Tornetta P 3rd (2017) Technique for placement of peri-implant antibiotics using antibiotic putty. J Orthop Trauma 31(12):e442–e445. https://​doi.​org/​10.​1097/​BOT.​0000000000000955​CrossRefPubMed

go back to reference Gristina AG (1987) Biomaterial-centered infection: microbial adhesion versus tissue integration. Science 237(4822):1588–1595. https://doi.org/10.1126/science.3629258CrossRefPubMed Gristina AG (1987) Biomaterial-centered infection: microbial adhesion versus tissue integration. Science 237(4822):1588–1595. https://​doi.​org/​10.​1126/​science.​3629258CrossRefPubMed