Skip to main content
Top
Published in: Journal of Cardiothoracic Surgery 1/2024

Open Access 01-12-2024 | Antibiotic | Research

Antibiotic-loaded bone cement fixation technique combined with bilateral pectoralis major muscle flaps tension-free management for sternal infection after midline sternotomy

Authors: Xia Jiang, Yong Xu, Mingqiu Li, Guoqing Jiao, Xiaosong Rong, Fanyu Bu

Published in: Journal of Cardiothoracic Surgery | Issue 1/2024

Login to get access

Abstract

Introduction

Deep sternal wound infection (DSWI) after midline sternotomy of cardiac surgery is a challenging complication that affects the outcome of surgery. This study aims to assess the clinical effectiveness of the antibiotic-loaded bone cement fixation technique combined with bilateral pectoralis major muscle flaps tension-free management in the treatment of DSWI.

Methods

We retrospectively analyzed 5 patients with DSWI who underwent antibiotic-loaded bone cement combined with bilateral pectoralis major muscle flaps for chest wall reconstruction after sternotomy for cardiac surgery in a tertiary hospital in China from January 2020 to December 2021. The clinical and follow-up data were retrospectively analyzed.

Results

All patients had no perioperative mortalities, no postoperative complications, 100% wound healing, and an average hospital stay length of 24 days. The follow-up periods were from 6 to 35 months (mean 19.6 months). None of the cases showed wound problems after initial reconstruction using antibiotic-loaded bone cement combined with bilateral pectoralis major muscle flaps.

Conclusions

We report our successful treatment of DSWI, using antibiotic-loaded bone cement fixation technique combined with bilateral pectoralis major muscle flaps tension-free management. The clinical and follow-up results are favorable.
Literature
1.
go back to reference El Oakley RM, Wright JE. Postoperative mediastinitis: classification and management. Ann Thorac Surg. 1996;61(3):1030–6.PubMedCrossRef El Oakley RM, Wright JE. Postoperative mediastinitis: classification and management. Ann Thorac Surg. 1996;61(3):1030–6.PubMedCrossRef
2.
go back to reference Ridderstolpe L, Gill H, Granfeldt H, Ahlfeldt H, Rutberg H. Superficial and deep sternal wound complications: incidence, risk factors and mortality. Eur J Cardiothorac Surg. 2001;20(6):1168–75.PubMedCrossRef Ridderstolpe L, Gill H, Granfeldt H, Ahlfeldt H, Rutberg H. Superficial and deep sternal wound complications: incidence, risk factors and mortality. Eur J Cardiothorac Surg. 2001;20(6):1168–75.PubMedCrossRef
3.
go back to reference Sjögren J, Malmsjö M, Gustafsson R, Ingemansson R. Poststernotomy mediastinitis: a review of conventional surgical treatments, vacuum-assisted closure therapy and presentation of the Lund University Hospital mediastinitis algorithm. Eur J Cardiothorac Surg. 2006;30(6):898–905.PubMedCrossRef Sjögren J, Malmsjö M, Gustafsson R, Ingemansson R. Poststernotomy mediastinitis: a review of conventional surgical treatments, vacuum-assisted closure therapy and presentation of the Lund University Hospital mediastinitis algorithm. Eur J Cardiothorac Surg. 2006;30(6):898–905.PubMedCrossRef
4.
go back to reference Chan M, Yusuf E, Giulieri S, Perrottet N, Von Segesser L, Borens O. Trampuz. A retrospective study of deep sternal wound infections: clinical and microbiological characteristics, treatment, and risk factors for complications. Diagn Microbiol Infect Dis. 2016;84(3):261–5.PubMedCrossRef Chan M, Yusuf E, Giulieri S, Perrottet N, Von Segesser L, Borens O. Trampuz. A retrospective study of deep sternal wound infections: clinical and microbiological characteristics, treatment, and risk factors for complications. Diagn Microbiol Infect Dis. 2016;84(3):261–5.PubMedCrossRef
5.
go back to reference Spindler N, Lehmann S, Steinau HU, Mohr FW, Langer S. Complication management after interventions on thoracic organs: deep sternal wound infections. Chirurg. 2015;86(3):228–3.PubMedCrossRef Spindler N, Lehmann S, Steinau HU, Mohr FW, Langer S. Complication management after interventions on thoracic organs: deep sternal wound infections. Chirurg. 2015;86(3):228–3.PubMedCrossRef
6.
go back to reference Strecker T, Rösch J, Horch RE, Weyand M, Kneser U. Sternal wound infections following cardiac surgery: risk factor analysis and interdisciplinary treatment. Heart Surg Forum. 2007;10(5):E366–71.PubMedCrossRef Strecker T, Rösch J, Horch RE, Weyand M, Kneser U. Sternal wound infections following cardiac surgery: risk factor analysis and interdisciplinary treatment. Heart Surg Forum. 2007;10(5):E366–71.PubMedCrossRef
7.
go back to reference Berg LT, Jaakkola P. Kuopio treatment strategy after deep sternal wound infection. Scand J Surg. 2013;102(1):3–8.PubMedCrossRef Berg LT, Jaakkola P. Kuopio treatment strategy after deep sternal wound infection. Scand J Surg. 2013;102(1):3–8.PubMedCrossRef
8.
go back to reference Gudbjartsson T, Jeppsson A, Sjögren J, Steingrimsson S, Geirsson A, Friberg O, Dunning J. Sternal wound infections following open heart surgery - a review. Scand Cardiovasc j. 2016;50(5–6):341–8.PubMedCrossRef Gudbjartsson T, Jeppsson A, Sjögren J, Steingrimsson S, Geirsson A, Friberg O, Dunning J. Sternal wound infections following open heart surgery - a review. Scand Cardiovasc j. 2016;50(5–6):341–8.PubMedCrossRef
9.
go back to reference Spindler N, Etz CD, Misfeld M, Josten C, Mohr FW, Langer S. Omentum flap as a salvage procedure in deep sternal wound infection. Ther Clin Risk Manag. 2017;13:1077–83.PubMedPubMedCentralCrossRef Spindler N, Etz CD, Misfeld M, Josten C, Mohr FW, Langer S. Omentum flap as a salvage procedure in deep sternal wound infection. Ther Clin Risk Manag. 2017;13:1077–83.PubMedPubMedCentralCrossRef
10.
go back to reference Hamaguchi R, Shekar PS, Johnson JA, Orgill DP. Current management of Sternal Wounds. Plast Reconstr Surg. 2021;148(6):e1012–25.CrossRef Hamaguchi R, Shekar PS, Johnson JA, Orgill DP. Current management of Sternal Wounds. Plast Reconstr Surg. 2021;148(6):e1012–25.CrossRef
11.
go back to reference Sahasrabudhe P, Jagtap R, Waykole P, Panse N, Bhargava P, Patwardhan S. Our experience with pectoralis major flap for management of sternal dehiscence: a review of 25 cases. Indian J Plast Surg. 2011;44(3):405–13.PubMedPubMedCentralCrossRef Sahasrabudhe P, Jagtap R, Waykole P, Panse N, Bhargava P, Patwardhan S. Our experience with pectoralis major flap for management of sternal dehiscence: a review of 25 cases. Indian J Plast Surg. 2011;44(3):405–13.PubMedPubMedCentralCrossRef
12.
go back to reference Coltro PS, Farina Junior JA. The role of the unilateral pectoralis major muscle flap in the treatment of deep sternal wound infection and dehiscence. J Card Surg. 2022;37(8):2315–16.PubMedCrossRef Coltro PS, Farina Junior JA. The role of the unilateral pectoralis major muscle flap in the treatment of deep sternal wound infection and dehiscence. J Card Surg. 2022;37(8):2315–16.PubMedCrossRef
14.
go back to reference Azi ML, Teixeira AA, Cotias RB, Joeris A, Kfuri M Jr. Membrane Induced Osteogenesis in the management of posttraumatic bone defects. J Orthop Trauma. 2016;30(10):545–50.PubMedCrossRef Azi ML, Teixeira AA, Cotias RB, Joeris A, Kfuri M Jr. Membrane Induced Osteogenesis in the management of posttraumatic bone defects. J Orthop Trauma. 2016;30(10):545–50.PubMedCrossRef
15.
go back to reference Fuchs KF, Heilig P, McDonogh M, Boelch S, Gbureck U, Meffert RH, et al. Cement-augmented screw fixation for calcaneal fracture treatment: a biomechanical study comparing two injectable bone substitutes. J Orthop Surg Res. 2020;15(1):533.PubMedPubMedCentralCrossRef Fuchs KF, Heilig P, McDonogh M, Boelch S, Gbureck U, Meffert RH, et al. Cement-augmented screw fixation for calcaneal fracture treatment: a biomechanical study comparing two injectable bone substitutes. J Orthop Surg Res. 2020;15(1):533.PubMedPubMedCentralCrossRef
16.
go back to reference Sultan AA, Samuel LT, Umpierrez E, Swiergosz A, Rabin J, Mahmood B, Mont MA. Routine use of commercial antibiotic-loaded bone cement in primary total joint arthroplasty: a critical analysis of the current evidence. Ann Transl Med. 2019;7(4):73.PubMedPubMedCentralCrossRef Sultan AA, Samuel LT, Umpierrez E, Swiergosz A, Rabin J, Mahmood B, Mont MA. Routine use of commercial antibiotic-loaded bone cement in primary total joint arthroplasty: a critical analysis of the current evidence. Ann Transl Med. 2019;7(4):73.PubMedPubMedCentralCrossRef
17.
go back to reference Buchholz HW, Englebrecht H. Depot effects of various antibiotics mixed with Palacos resins. Chirurg. 1970;41(11):511–5.PubMed Buchholz HW, Englebrecht H. Depot effects of various antibiotics mixed with Palacos resins. Chirurg. 1970;41(11):511–5.PubMed
18.
go back to reference Singh VA, Wei CC, Haseeb A, Shanmugam R, Ju CS. JectOS® versus PMMA Vancomycin-loaded cement: the biomechanical and antimicrobial properties. J Orthop Surg (Hong Kong). 2019;27(1):2309499018822247.PubMedCrossRef Singh VA, Wei CC, Haseeb A, Shanmugam R, Ju CS. JectOS® versus PMMA Vancomycin-loaded cement: the biomechanical and antimicrobial properties. J Orthop Surg (Hong Kong). 2019;27(1):2309499018822247.PubMedCrossRef
19.
go back to reference Hanssen AD, Spangehl MJ. Practical applications of antibiotic loaded bone cement for treatment of infected joint replacement. Clin Orthop Relat Res. 2004;427:79–85.CrossRef Hanssen AD, Spangehl MJ. Practical applications of antibiotic loaded bone cement for treatment of infected joint replacement. Clin Orthop Relat Res. 2004;427:79–85.CrossRef
20.
go back to reference Klesius AA, Dzemali O, Simon A, Kleine P, Abdel-Rahman U, Herzog C, et al. Successful treatment of deep sternal infections following open heart surgery by bilateral pectoralis major flaps. Eur J Cardiothorac Surg. 2004;25(2):218–23.PubMedCrossRef Klesius AA, Dzemali O, Simon A, Kleine P, Abdel-Rahman U, Herzog C, et al. Successful treatment of deep sternal infections following open heart surgery by bilateral pectoralis major flaps. Eur J Cardiothorac Surg. 2004;25(2):218–23.PubMedCrossRef
21.
go back to reference Zeitani J, Pompeo E, Nardi P, Sergiacomi G, Scognamiglio M, Chiariello G, et al. Early and long-term results of pectoralis muscle flap reconstruction versus sternal rewiring following failed sternal closure. Eur J Cardiothorac Surg. 2013;43(6):e144–150.PubMedCrossRef Zeitani J, Pompeo E, Nardi P, Sergiacomi G, Scognamiglio M, Chiariello G, et al. Early and long-term results of pectoralis muscle flap reconstruction versus sternal rewiring following failed sternal closure. Eur J Cardiothorac Surg. 2013;43(6):e144–150.PubMedCrossRef
22.
go back to reference Netscher DT, Eladoumikdachi F, Goodman CM. Rectus abdominis muscle flaps used successfully for median sternotomy wounds after ipsilateral internal mammary artery ligation. Ann Plast Surg. 2001;47(3):223–8.PubMedCrossRef Netscher DT, Eladoumikdachi F, Goodman CM. Rectus abdominis muscle flaps used successfully for median sternotomy wounds after ipsilateral internal mammary artery ligation. Ann Plast Surg. 2001;47(3):223–8.PubMedCrossRef
23.
go back to reference Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309–32.PubMedCrossRef Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309–32.PubMedCrossRef
24.
go back to reference Toumpoulis IK, Anagnostopoulos CE, DeRose JJ. Impact of deep sternal wound infection on long term survival after coronary artery bypass grafting. Chest. 2005;127(2):464–71.PubMedCrossRef Toumpoulis IK, Anagnostopoulos CE, DeRose JJ. Impact of deep sternal wound infection on long term survival after coronary artery bypass grafting. Chest. 2005;127(2):464–71.PubMedCrossRef
25.
go back to reference Filsoufi F, Castillo JG, Rahmanian PB, Broumand SR, Silvay G, Carpentier A, Adams DH. Epidemiology of deep sternal wound infection in cardiac surgery. J Cardiothorac Vasc Anesth. 2009;23(4):488–94.PubMedCrossRef Filsoufi F, Castillo JG, Rahmanian PB, Broumand SR, Silvay G, Carpentier A, Adams DH. Epidemiology of deep sternal wound infection in cardiac surgery. J Cardiothorac Vasc Anesth. 2009;23(4):488–94.PubMedCrossRef
26.
go back to reference Hever P, Singh P, Eiben I, Eiben P, Nikkhah D. The management of deep sternal wound infection: literature review and reconstructive algorithm. JPRAS Open. 2021;6:28:77–89.CrossRef Hever P, Singh P, Eiben I, Eiben P, Nikkhah D. The management of deep sternal wound infection: literature review and reconstructive algorithm. JPRAS Open. 2021;6:28:77–89.CrossRef
28.
go back to reference Vos RJ, Van Putte BP, Kloppenburg GTL. Prevention of deep sternal wound infection in cardiac surgery: a literature review. J Hosp Infect. 2018;100(4):411–20.PubMedCrossRef Vos RJ, Van Putte BP, Kloppenburg GTL. Prevention of deep sternal wound infection in cardiac surgery: a literature review. J Hosp Infect. 2018;100(4):411–20.PubMedCrossRef
29.
go back to reference Zeitani J, Penta de Peppo A, Moscarelli M, Guerrieri Wolf L, Scafuri A, Nardi P, et al. Influence of sternal size and inadvertent paramedian sternotomy on stability of the closure site: a clinical and mechanical study. J Thorac Cardiovasc Surg. 2006;132(1):38–42.PubMedCrossRef Zeitani J, Penta de Peppo A, Moscarelli M, Guerrieri Wolf L, Scafuri A, Nardi P, et al. Influence of sternal size and inadvertent paramedian sternotomy on stability of the closure site: a clinical and mechanical study. J Thorac Cardiovasc Surg. 2006;132(1):38–42.PubMedCrossRef
30.
go back to reference Song F, Liu Z. Bilateral-pectoral major muscle advancement flap combined with vacuum-assisted closure therapy for the treatment of deep sternal wound infections after cardiac surgery. J Cardiothorac Surg. 2020;15(1):227.PubMedPubMedCentralCrossRef Song F, Liu Z. Bilateral-pectoral major muscle advancement flap combined with vacuum-assisted closure therapy for the treatment of deep sternal wound infections after cardiac surgery. J Cardiothorac Surg. 2020;15(1):227.PubMedPubMedCentralCrossRef
31.
go back to reference Waked K, Ballaux P, Goossens D, Cathenis K. The ‘Two bridges technique’ for sternal wound closure. The use of vacuum-assisted closure for the treatment of deep sternal wound defects: a centre-specific technique. Int Wound J. 2018;15(2):198–204.PubMedPubMedCentralCrossRef Waked K, Ballaux P, Goossens D, Cathenis K. The ‘Two bridges technique’ for sternal wound closure. The use of vacuum-assisted closure for the treatment of deep sternal wound defects: a centre-specific technique. Int Wound J. 2018;15(2):198–204.PubMedPubMedCentralCrossRef
32.
go back to reference Serebrakian AT, Ortiz R, Kogosov A, Winograd JM. Interlocking pectoralis major advancement and turnover flaps for sternal wound reconstruction: a combined approach for complex wounds. J Plast Reconstr Aesthet Surg. 2022;75(8):2831–70.PubMedCrossRef Serebrakian AT, Ortiz R, Kogosov A, Winograd JM. Interlocking pectoralis major advancement and turnover flaps for sternal wound reconstruction: a combined approach for complex wounds. J Plast Reconstr Aesthet Surg. 2022;75(8):2831–70.PubMedCrossRef
33.
go back to reference Alebrahim K, Al-Ebrahim E. Prevention, Classification and Management Review of Deep Sternal Wound Infection. Heart Surg Forum. 2020;23(5):E652–7.PubMedCrossRef Alebrahim K, Al-Ebrahim E. Prevention, Classification and Management Review of Deep Sternal Wound Infection. Heart Surg Forum. 2020;23(5):E652–7.PubMedCrossRef
34.
go back to reference Myllykangas HM, Halonen J, Husso A, Berg LT. Decreasing complications of pectoralis major muscle flap reconstruction with two modalities of negative pressure wound therapy. Scand J Surg. 2022;111(1):14574969211043330.PubMedCrossRef Myllykangas HM, Halonen J, Husso A, Berg LT. Decreasing complications of pectoralis major muscle flap reconstruction with two modalities of negative pressure wound therapy. Scand J Surg. 2022;111(1):14574969211043330.PubMedCrossRef
35.
go back to reference Rashed A, Gombocz K, Alotti N, Verzar Z. Is sternal rewiring mandatory in surgical treatment of deep sternal wound infections? J Thorac Dis. 2018;10(4):2412–19.PubMedPubMedCentralCrossRef Rashed A, Gombocz K, Alotti N, Verzar Z. Is sternal rewiring mandatory in surgical treatment of deep sternal wound infections? J Thorac Dis. 2018;10(4):2412–19.PubMedPubMedCentralCrossRef
36.
go back to reference Martin C, Alaya M, Mallet MN, Viviand X, Ennabli K, Said R, De Micco P. Penetration of Vancomycin into mediastinal and cardiac tissues in humans. Antimicrob Agents Chemother. 1994;38:396–9.PubMedPubMedCentralCrossRef Martin C, Alaya M, Mallet MN, Viviand X, Ennabli K, Said R, De Micco P. Penetration of Vancomycin into mediastinal and cardiac tissues in humans. Antimicrob Agents Chemother. 1994;38:396–9.PubMedPubMedCentralCrossRef
37.
go back to reference Andreas M, Zeitlinger M, Hoeferl M, Jaeger W, Zimpfer D, Hiesmayr JM, et al. Internal mammary artery harvesting influences antibiotic penetration into presternal tissue. Ann Thorac Surg. 2013;95(4):1323–30.PubMedCrossRef Andreas M, Zeitlinger M, Hoeferl M, Jaeger W, Zimpfer D, Hiesmayr JM, et al. Internal mammary artery harvesting influences antibiotic penetration into presternal tissue. Ann Thorac Surg. 2013;95(4):1323–30.PubMedCrossRef
38.
go back to reference Seligson D, Berling S. Antibiotic-laden PMMA bead chains for the prevention of infection in compound fractures: current state of the art. Eur J Orthop Surg Traumatol. 2015;25(6):969–74.PubMedCrossRef Seligson D, Berling S. Antibiotic-laden PMMA bead chains for the prevention of infection in compound fractures: current state of the art. Eur J Orthop Surg Traumatol. 2015;25(6):969–74.PubMedCrossRef
39.
go back to reference van Vugt TAG, Arts JJ, Geurts JAP. Antibiotic-loaded polymethylmethacrylate beads and spacers in Treatment of Orthopedic Infections and the role of Biofilm formation. Front Microbiol. 2019;10:1626.PubMedPubMedCentralCrossRef van Vugt TAG, Arts JJ, Geurts JAP. Antibiotic-loaded polymethylmethacrylate beads and spacers in Treatment of Orthopedic Infections and the role of Biofilm formation. Front Microbiol. 2019;10:1626.PubMedPubMedCentralCrossRef
40.
go back to reference Funk GA, Burkes JC, Cole KA, Rahaman MN, McIff TE. Antibiotic elution and mechanical strength of PMMA bone cement loaded with Borate Bioactive Glass. J Bone Jt Infect. 2018;3(4):187–96.PubMedPubMedCentralCrossRef Funk GA, Burkes JC, Cole KA, Rahaman MN, McIff TE. Antibiotic elution and mechanical strength of PMMA bone cement loaded with Borate Bioactive Glass. J Bone Jt Infect. 2018;3(4):187–96.PubMedPubMedCentralCrossRef
41.
go back to reference Cotogni P, Barbero C, Rinaldi M. Deep sternal wound infection after cardiac surgery: evidences and controversies. World J Crit Care Med. 2015;4(4):265–73.PubMedPubMedCentralCrossRef Cotogni P, Barbero C, Rinaldi M. Deep sternal wound infection after cardiac surgery: evidences and controversies. World J Crit Care Med. 2015;4(4):265–73.PubMedPubMedCentralCrossRef
42.
go back to reference Lepelletier D, Bourigault C, Roussel JC, Lasserre C, Leclère B, Corvec S, et al. Epidemiology and prevention of surgical site infections after cardiac surgery. Med Mal Infect. 2013;43(10):403–9.PubMedCrossRef Lepelletier D, Bourigault C, Roussel JC, Lasserre C, Leclère B, Corvec S, et al. Epidemiology and prevention of surgical site infections after cardiac surgery. Med Mal Infect. 2013;43(10):403–9.PubMedCrossRef
43.
go back to reference Bosso JA, Nappi J, Rudisill C, Wellein M, Bookstaver PB, Swindler J, Mauldin PD. Relationship between Vancomycin trough concentrations and nephrotoxicity: a prospective multicenter trial. Antimicrob Agents Chemiother. 2011;55(12):5475–79.CrossRef Bosso JA, Nappi J, Rudisill C, Wellein M, Bookstaver PB, Swindler J, Mauldin PD. Relationship between Vancomycin trough concentrations and nephrotoxicity: a prospective multicenter trial. Antimicrob Agents Chemiother. 2011;55(12):5475–79.CrossRef
44.
go back to reference Davies SW, Guidry CA, Petroze RT, Hranjec T, Sawyer RG. Vancomycin and nephrotoxicity: just another myth? J Trauma Acute Care Surg. 2013;75(5):830–5.PubMedPubMedCentralCrossRef Davies SW, Guidry CA, Petroze RT, Hranjec T, Sawyer RG. Vancomycin and nephrotoxicity: just another myth? J Trauma Acute Care Surg. 2013;75(5):830–5.PubMedPubMedCentralCrossRef
45.
go back to reference Titley-Diaz WH, De Cicco FL, Suture H. 2022 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan&#8211. Titley-Diaz WH, De Cicco FL, Suture H. 2022 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan&#8211.
Metadata
Title
Antibiotic-loaded bone cement fixation technique combined with bilateral pectoralis major muscle flaps tension-free management for sternal infection after midline sternotomy
Authors
Xia Jiang
Yong Xu
Mingqiu Li
Guoqing Jiao
Xiaosong Rong
Fanyu Bu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2024
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-024-02749-0

Other articles of this Issue 1/2024

Journal of Cardiothoracic Surgery 1/2024 Go to the issue