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01-02-2020 | Antibiotic | Expert Statement

Clostridioides difficile (formerly Clostridium difficile) infection in the critically ill: an expert statement

Authors: Massimo Antonelli, Ignacio Martin-Loeches, George Dimopoulos, Antonio Gasbarrini, Maria Sole Vallecoccia

Published in: Intensive Care Medicine | Issue 2/2020

Abstract

Clostridioides difficile (formerly Clostridium difficile) infection (CDI) represents a worrisome condition, often underestimated, with severe clinical presentations, frequently requiring intensive care unit (ICU) admission. The aim of the present expert statement was to give an overview of the management of CDI in critically ill patients, for whom CDI represents a redoubtable problem, in large part related to the use and abuse of antibiotics. The available knowledge about pathophysiology, risk factors, diagnosis and treatment concerning critical care patients affected by CDI has been reviewed, even though most of the existing information come from studies performed outside the ICU and the evidence on several issues in this specific context is scarce. The adoption of potential preventive and therapeutic strategies aimed to stem the phenomenon were discussed, including the faecal microbiota transplantation. This possibility could represent a highly interesting option in critically ill patients, but current evidence is limited and future well designed studies are needed. A special insight on the specific challenges that the ICU physicians may face caring for the critically ill patients with CDI was also proposed.

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Title: Clostridioides difficile (formerly Clostridium difficile) infection in the critically ill: an expert statement
Authors: Massimo Antonelli
Ignacio Martin-Loeches
George Dimopoulos
Antonio Gasbarrini
Maria Sole Vallecoccia
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keywords: Antibiotic
Respiratory Microbiota
Clostridioides Difficile
Published in: Intensive Care Medicine / Issue 2/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-019-05873-x

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Clostridioides difficile (formerly Clostridium difficile) infection in the critically ill: an expert statement

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