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Open Access 31-01-2023 | Antibiotic | Correspondence

Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter

Authors: Uwe Liebchen, Josef Briegel, Alexander Brinkmann, Otto Frey, Sebastian G. Wicha

Published in: Intensive Care Medicine | Issue 4/2023

Excerpt

Therapeutic drug monitoring (TDM) of antibiotics is recommended and increasingly used in critically ill patients to optimize target attainment and account for interpatient pharmacokinetic variability [1]. Beyond TDM, critically ill patients could benefit from model-informed precision dosing (MIPD), a newer and not yet extensively employed but promising technology integrating TDM results into mathematical models [2]. We would like to compare and contrast two recently published randomized controlled trials investigating the effect of TDM and MIPD on critically ill patient outcomes. …

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Title: Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter
Authors: Uwe Liebchen
Josef Briegel
Alexander Brinkmann
Otto Frey
Sebastian G. Wicha
Publication date: 31-01-2023
Publisher: Springer Berlin Heidelberg
Keywords: Antibiotic
Piperacillin
Published in: Intensive Care Medicine / Issue 4/2023
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-023-06990-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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