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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Review

Antibiotic strategies in the era of multidrug resistance

Authors: George Karam, Jean Chastre, Mark H. Wilcox, Jean-Louis Vincent

Published in: Critical Care | Issue 1/2016

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Abstract

The rapid emergence and dissemination of antibiotic-resistant microorganisms in ICUs worldwide threaten adequate antibiotic coverage of infected patients in this environment. The causes of this problem are multifactorial, but the core issues are clear: the emergence of antibiotic resistance is highly correlated with selective pressure resulting from inappropriate use of these drugs. Because a significant increase in mortality is observed when antibiotic therapy is delayed in infected ICU patients, initial therapy should be broad enough to cover all likely pathogens. Receipt of unnecessary prolonged broad-spectrum antibiotics, however, should be avoided. Local microbiologic data are extremely important to predict the type of resistance that may be present for specific causative bacteria, as is prior antibiotic exposure, and antibiotic choices should thus be made at an individual patient level.
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Metadata
Title
Antibiotic strategies in the era of multidrug resistance
Authors
George Karam
Jean Chastre
Mark H. Wilcox
Jean-Louis Vincent
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1320-7

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