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Neurocritical Care

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01-04-2013 | Original Article

Antibiotic-Impregnated Versus Silver-Bearing External Ventricular Drainage Catheters: Preliminary Results in a Randomized Controlled Trial

Authors: K. M. L. Winkler, C. M. Woernle, M. Seule, U. Held, R. L. Bernays, E. Keller

Published in: Neurocritical Care | Issue 2/2013

Abstract

Background

Evaluation of antibiotic-impregnated (AI) and ionized silver particle coated external ventricular drainage catheters (EVD) in patients with subarachnoid (SAH) or intracranial hemorrhage (ICH).

Methods

Between February 2011 and June 2012, 40 patients with acute hydrocephalus due to SAH, ICH or intraventricular hemorrhage were enrolled in a prospective, randomized, mono-center pilot study. Primary endpoints were defined as: number of events of cerebrospinal fluid (CSF) infections. Secondary endpoints were defined as: neurosurgical complications following the placement of the EVD, number of revisions of EVD catheters, and cost effectiveness.

Results

Sixty-one EVD placements in 40 patients, 32 antibiotic-coated (Bactiseal^®), 29 silver-bearing catheters (VentriGuard^®), have been performed. Confirmed or high suspicion of CSF infections occurred in 11 out of 61 events (confirmed infection: p = 0.71, probable infection: p = 0.90). Revisions of EVD were needed in 13 cases (22 %) due to CSF infection, dysfunction, impaired healing, or malplacement (p = 0.37).

Conclusion

Regarding CSF infection rate and dysfunction, no statistical significant differences between the two EVD catheters Bactiseal^® versus VentriGuard^® were found. The silver-bearing catheter might offer a safe and cost-conscious alternative to the AI catheter.

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Title: Antibiotic-Impregnated Versus Silver-Bearing External Ventricular Drainage Catheters: Preliminary Results in a Randomized Controlled Trial
Authors: K. M. L. Winkler
C. M. Woernle
M. Seule
U. Held
R. L. Bernays
E. Keller
Publication date: 01-04-2013
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 2/2013
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-013-9816-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Antibiotic-Impregnated Versus Silver-Bearing External Ventricular Drainage Catheters: Preliminary Results in a Randomized Controlled Trial

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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