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01-11-2014 | Editorial

Antibiotic dosing in the critically ill: asking the same questions but expecting different answers

Authors: P. Póvoa, I. Spriet, J. R. Zahar

Published in: Intensive Care Medicine | Issue 11/2014

Excerpt

The approach of severe sepsis and septic shock has three fundamental steps: early recognition, hemodynamic resuscitation and early empiric antibiotic therapy with focus control if appropriate. Empiric antibiotic therapy involves two decisions: the choice of antibiotics, which depends on the presumed focus and pathogens, and dosing of antibiotics, which should be appropriate along with a correct route and mode of administration [1]. …

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Roberts JA, De Waele JJ, Dimopoulos G, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Lipman J (2012) DALI: defining antibiotic levels in intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic. BMC Infect Dis 12:152PubMedCrossRefPubMedCentral

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Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Lipman J (2013) Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial. Clin Infect Dis 56:236–244PubMedCrossRef

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Goncalves-Pereira J, Oliveira BS, Janeiro S, Estilita J, Monteiro C, Salgueiro A, Vieira A, Gouveia J, Paulino C, Bento L, Povoa P (2012) Continuous infusion of piperacillin/tazobactam in septic critically ill patients—a multicenter propensity matched analysis. PLoS One 7:e49845PubMedCrossRefPubMedCentral

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Mohd Hafiz AA, Staatz CE, Kirkpatrick CM, Lipman J, Roberts JA (2012) Continuous infusion vs. bolus dosing: implications for beta-lactam antibiotics. Minerva Anestesiol 78:94–104PubMed

Title: Antibiotic dosing in the critically ill: asking the same questions but expecting different answers
Authors: P. Póvoa
I. Spriet
J. R. Zahar
Publication date: 01-11-2014
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 11/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3477-3

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Antibiotic dosing in the critically ill: asking the same questions but expecting different answers

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