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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2014

Open Access 01-12-2014 | Research article

Anti-wrinkle effects of fermented and non-fermented Cyclopia intermedia in hairless mice

Authors: A-Rang Im, Jae Hyoung Song, Mi Young Lee, Sung Hum Yeon, Key An Um, Sungwook Chae

Published in: BMC Complementary Medicine and Therapies | Issue 1/2014

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Abstract

Background

The fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, an herbal tea indigenous to South Africa with reported anti-wrinkle effects. Wrinkle formation caused by photoaging clearly involves changes in extracellular matrix components and mechanical properties of the skin.

Methods

The inhibitory effects of honeybush extract and fermented honeybush on wrinkle formation were determined by analyzing skin replicas, histologically examining epidermal thickness, and identifying damage to collagen fibers.

Results

Honeybush extract and fermented honeybush reduced the length and depth of skin winkles caused by UV irradiation and inhibited thickening of the epidermal layer, in addition to suppressing collagen tissue breakdown reactions, indicating its potential use as a skin wrinkle prevention agent.

Conclusions

This in vivo study demonstrates that honeybush produces significant anti-wrinkle effects and is therefore of interest in anti-aging skin care products.
Appendix
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Metadata
Title
Anti-wrinkle effects of fermented and non-fermented Cyclopia intermedia in hairless mice
Authors
A-Rang Im
Jae Hyoung Song
Mi Young Lee
Sung Hum Yeon
Key An Um
Sungwook Chae
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2014
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/1472-6882-14-424

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