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Chinese Medicine
Published in: Chinese Medicine 1/2010

Open Access 01-12-2010 | Research

Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells

Authors: Roy Chi-Yan Choi, Zhiyong Jiang, Heidi Qun Xie, Anna Wing-Han Cheung, David Tai-Wai Lau, Qiang Fu, Tina Tingxia Dong, Jijun Chen, Zhengtao Wang, Karl Wah-Keung Tsim

Published in: Chinese Medicine | Issue 1/2010

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Abstract

Background

Radix notoginseng is used in Chinese medicine to improve blood circulation and clotting; however, the pharmacological activities of other parts of Panax notoginseng have yet to be explored. The present study reports the anti-oxidative effects of various parts of Panax notoginseng.

Methods

Various parts of Panax notoginseng, including the biennial flower, stem-leaf, root-rhizome, fiber root and sideslip, were used to prepare extracts and analyzed for their anti-oxidation effects, namely suppressing xanthine oxidase activity, H2O2-induced cytotoxicity and H2O2-induced ROS formation.

Results

Among various parts of the herb (biennial flower, stem-leaf, root-rhizome, fiber root and sideslip), the water extract of the biennial flower showed the strongest effects in (i) inhibiting the enzymatic activity of xanthine oxidase and (ii) protecting neuronal PC12 cells against H2O2-induced cytotoxicity. Only the water extracts demonstrated such anti-oxidative effects while the ethanol extracts did not exert significant effects in suppressing xanthine oxidase and H2O2-induced neuronal cytotoxicity.

Conclusions

The present study demonstrates the biennial flower of Panax notoginseng to have neuroprotection effect on cultured neurons and the underlying protection mechanism may involve anti-oxidation.
Appendix
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Metadata
Title
Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells
Authors
Roy Chi-Yan Choi
Zhiyong Jiang
Heidi Qun Xie
Anna Wing-Han Cheung
David Tai-Wai Lau
Qiang Fu
Tina Tingxia Dong
Jijun Chen
Zhengtao Wang
Karl Wah-Keung Tsim
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2010
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/1749-8546-5-38

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