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01-12-2011 | Original Paper

Anti-inflammatory properties of a new undecyl-rhamnoside (APRC11) against P. acnes

Authors: O. Isard, M. Lévêque, A. C. Knol, M. F. Ariès, A. Khammari, J. M. Nguyen, N. Castex-Rizzi, B. Dréno

Published in: Archives of Dermatological Research | Issue 10/2011

Abstract

Acne vulgaris is a skin disease affecting pilosebaceous glands in which Propionibacterium acnes (P. acnes) induced inflammation plays a central role. In order to develop new therapies against the inflammatory events, we evaluated the modulating effect of a new undecyl-rhamnoside, APRC11, on different markers of the inflammation. For this purpose, normal human keratinocytes taken from five healthy donors were pre-incubated for 24 h with APRC11 or Zinc Gluconate (Zn) which was used as reference molecule for its anti-inflammatory properties. Then, keratinocytes were stimulated with P. acnes Membrane Fraction for 6 h, in the presence of either APRC11 or Zn. Different markers were evaluated at mRNA level using a Luminex-based Quantigene array system and at protein level using an ELISA test and a Luminex array system. Results showed that P. acnes significantly increased the expression of IL-1α, IL-1RA, IL-8 and MMP-9. A 24-h treatment with APRC11 prior to the P. acnes stimulation down-regulated the P. acnes-induced cytokines over expression (IL-1α, IL-8 and MMP-9) and up-regulated IL-1RA level in a similar manner than Zn. These regulations were noted at both protein and mRNA levels. In conclusion, the new undecyl-rhamnoside APRC11 is able to down-regulate the expression of molecules implicated in cutaneous inflammation and whose expression is induced by P. acnes, confirming its potential interest in inflammatory acne.

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Title: Anti-inflammatory properties of a new undecyl-rhamnoside (APRC11) against P. acnes
Authors: O. Isard
M. Lévêque
A. C. Knol
M. F. Ariès
A. Khammari
J. M. Nguyen
N. Castex-Rizzi
B. Dréno
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 10/2011
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-011-1147-7

At a glance: The STEP trials

Springer Medicine

Anti-inflammatory properties of a new undecyl-rhamnoside (APRC11) against P. acnes

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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