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Neurological Sciences
Published in: Neurological Sciences 4/2015

01-04-2015 | Letter to the Editor

Anti-GAD antibody-positive myoclonic leg jerks

Authors: D. Velardo, A. Nuara, V. Martinelli, G. Comi, R. Fazio

Published in: Neurological Sciences | Issue 4/2015

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Excerpt

High levels of autoantibodies directed against glutamic acid decarboxylase (GAD) are associated with stiff-person syndrome (SPS). However, other neurological syndromes have been described in association with anti-GAD antibodies, defining a novel group of syndromes, collectively named “hyperexcitability disorders”. Here, we describe a patient complaining for acute onset of involuntary jerk movements in his legs, associated with pathologically increased level of anti-GAD antibodies. …
Literature
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Saiz A, Blanco Y, Sabater L, González F, Bataller L, Casamitjana R, Ramió-Torrentà L, Graus F (2008) Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 131(Pt 10):2553–2563CrossRefPubMed
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Dayalu P, Teener JW (2012) Stiff Person syndrome and other anti-GAD-associated neurologic disorders. Semin Neurol 32(5):544–549CrossRefPubMed
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Alexopoulos H, Dalakas MC (2013) Immunology of stiff person syndrome and other GAD-associated neurological disorders. Expert Rev Clin Immunol 9(11):1043–1053CrossRefPubMed
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Nemni R, Braghi S, Natali-Sora MG, Lampasona V, Bonifacio E, Comi G, Canal N (1994) Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy. Ann Neurol 36(4):665–667CrossRefPubMed
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Metadata
Title
Anti-GAD antibody-positive myoclonic leg jerks
Authors
D. Velardo
A. Nuara
V. Martinelli
G. Comi
R. Fazio
Publication date
01-04-2015
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 4/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-014-2058-0

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