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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2017

Open Access 01-12-2017 | Research article

Anti-diabetic activity of aerial parts of Sarcopoterium spinosum

Authors: Uriel Elyasiyan, Adi Nudel, Nir Skalka, Konstantin Rozenberg, Elyashiv Drori, Rachela Oppenheimer, Zohar Kerem, Tovit Rosenzweig

Published in: BMC Complementary Medicine and Therapies | Issue 1/2017

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Abstract

Background

Sarcopoterium spinosum (S. spinosum) is used by Bedouin medicinal practitioners for the treatment of diabetes. While the anti-diabetic activity of S. spinosum root extract was validated in previous studies, the activity of aerial parts of the same plants has not been elucidated yet. The aim of this study was to clarify the glucose lowering properties of the aerial parts of the shrub.

Methods

Anti-diabetic properties were evaluated by measuring the activity of carbohydrate digesting enzymes, glucose uptake into 3 T3-L1 adipocytes, and insulin secretion. Insulin signaling cascade was followed in L6 myotubes using Western blot and PathScan analysis.

Results

Activity of α-amylase and α-glucosidase was inhibited by extracts of all S. spinosum organs. Basal and glucose-induced insulin secretion was measured in Min6 cells and found to be enhanced as well. Glucose uptake was induced by all S. spinosum extracts, with roots found to be the most effective and fruits the least.
The effect of S. spinosum on Akt phosphorylation was minor compared to insulin effect. However, GSK3β and PRAS40, which are downstream elements of the insulin cascade, were found to be highly phosphorylated by S. spinosum extracts. Inhibition of PI3K and Akt, but not AMPK and ERK, abrogated the induction of glucose uptake by the aerial parts of the shrub.

Conclusion

The aerial organs of S. spinosum have anti-diabetic properties and may be used as a basis for the development of dietary supplements or to identify new agents for the treatment of type 2 diabetes.
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Metadata
Title
Anti-diabetic activity of aerial parts of Sarcopoterium spinosum
Authors
Uriel Elyasiyan
Adi Nudel
Nir Skalka
Konstantin Rozenberg
Elyashiv Drori
Rachela Oppenheimer
Zohar Kerem
Tovit Rosenzweig
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2017
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-017-1860-7

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