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Published in: Cancer Causes & Control 2/2018

01-02-2018 | Original paper

Anthropometric characteristics and ovarian cancer risk and survival

Authors: Albina N. Minlikeeva, Kirsten B. Moysich, Paul C. Mayor, John L. Etter, Rikki A. Cannioto, Roberta B. Ness, Kristen Starbuck, Robert P. Edwards, Brahm H. Segal, Sashikant Lele, Kunle Odunsi, Brenda Diergaarde, Francesmary Modugno

Published in: Cancer Causes & Control | Issue 2/2018

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Abstract

Purpose

Multiple studies have examined the role of anthropometric characteristics in ovarian cancer risk and survival; however, their results have been conflicting. We investigated the associations between weight change, height and height change and risk and outcome of ovarian cancer using data from a large population-based case–control study.

Methods

Data from 699 ovarian cancer cases and 1,802 controls who participated in the HOPE study were included. We used unconditional logistic regression adjusted for age, race, number of pregnancies, use of oral contraceptives, and family history of breast or ovarian cancer to examine the associations between self-reported height and weight and height change with ovarian cancer risk. Cox proportional hazards regression models adjusted for age and stage were used to examine the association between the exposure variables and overall and progression-free survival among ovarian cancer cases.

Results

We observed an increased risk of ovarian cancer mortality and progression for gaining more than 20 pounds between ages 18–30, HR 1.36; 95% CI 1.05–1.76, and HR 1.31; 95% CI 1.04–1.66, respectively. Losing weight and gaining it back multiple times was inversely associated with both ovarian cancer risk, OR 0.78; 95% CI 0.63–0.97 for 1–4 times and OR 0.73; 95% CI 0.54–0.99 for 5–9 times, and mortality, HR 0.63; 95% CI 0.40–0.99 for 10–14 times. Finally, being taller during adolescence and adulthood was associated with increased risk of mortality. Taller stature and weight gain over lifetime were not related to ovarian cancer risk.

Conclusions

Our results suggest that height and weight and their change over time may influence ovarian cancer risk and survival. These findings suggest that biological mechanisms underlying these associations may be hormone driven and may play an important role in relation to ovarian carcinogenesis and tumor progression.
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Metadata
Title
Anthropometric characteristics and ovarian cancer risk and survival
Authors
Albina N. Minlikeeva
Kirsten B. Moysich
Paul C. Mayor
John L. Etter
Rikki A. Cannioto
Roberta B. Ness
Kristen Starbuck
Robert P. Edwards
Brahm H. Segal
Sashikant Lele
Kunle Odunsi
Brenda Diergaarde
Francesmary Modugno
Publication date
01-02-2018
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 2/2018
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-017-0997-5

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