Skip to main content
Top
Published in: Journal of Parasitic Diseases 4/2015

01-12-2015 | Original Article

Anthelmintic efficacy of crude neem (Azadirachta indica) leaf powder against bovine strongylosis

Authors: Nirmala Jamra, Giridhari Das, Priyanka Singh, Manjurul Haque

Published in: Journal of Parasitic Diseases | Issue 4/2015

Login to get access

Abstract

The present study was conducted to evaluate the anthelmintic efficacy of crude neem (Azadirachta indica) leaf powder against strongyle infections in cattle. Based on copro-examination, 30 cattle positive for strongyle infection with at least 250 [eggs per gram (EPG) of faeces] were selected and grouped as A, B and C (10 animals/group). Group A and B were treated respectively with fendendazole and neem leaf powder @ 5 and 500 mg/kg body weight, whereas Group C served as infected untreated control. Faecal sample from each animal of these groups was examined on day 0, 7, 14 and 28 post treatments and EPG was determined. The result showed significant decrease (p < 0.05) in EPG in Group A and B after day 7 post treatment but there was no significant variation in terms of EPG in control group. Thus it can be concluded that crude neem leaf powder has anthelmintic property and it can further be studied to isolate the active component to produce herbal anthelminthics.
Literature
go back to reference Akhtar MS, Iqbal Z, Khan MN, Lateef M (2000) Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo Pakistan subcontinent. Small Rumin Res 38:99–107CrossRef Akhtar MS, Iqbal Z, Khan MN, Lateef M (2000) Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo Pakistan subcontinent. Small Rumin Res 38:99–107CrossRef
go back to reference Ali M (2005) Prevalence and treatment trials against Gastrodiscus infestation and its effect on various blood components in horses. M.Sc. (Hons.) thesis, Deptt. Clin. Med. Surg., University of Veterinary and Animal Sciences, Lahore, Pakistan Ali M (2005) Prevalence and treatment trials against Gastrodiscus infestation and its effect on various blood components in horses. M.Sc. (Hons.) thesis, Deptt. Clin. Med. Surg., University of Veterinary and Animal Sciences, Lahore, Pakistan
go back to reference Baldo RC (2001) Comparative efficacy of pineapple (Ananas comosus) leaves bolus and albendazole against gastrointestinal nematodes of sheep. DVM. University of the Philippines, Department of Vet Parasitol, p 38 Baldo RC (2001) Comparative efficacy of pineapple (Ananas comosus) leaves bolus and albendazole against gastrointestinal nematodes of sheep. DVM. University of the Philippines, Department of Vet Parasitol, p 38
go back to reference Chandrawathani P, Brelin D, Nor FAS, Adnan M, Jamnah O, Rehana AS, Hoglund J, Waller PJ (2002) Evaluation of the neem tree (Azadirachta indica) as a herbal anthelmintic for nematode parasite control in small ruminants in Malaysia. Trop Biomed 19:41–48 Chandrawathani P, Brelin D, Nor FAS, Adnan M, Jamnah O, Rehana AS, Hoglund J, Waller PJ (2002) Evaluation of the neem tree (Azadirachta indica) as a herbal anthelmintic for nematode parasite control in small ruminants in Malaysia. Trop Biomed 19:41–48
go back to reference Coles GC, Bauer C, Borgsteede FHM, Geerts S, Walker PJ (1992) World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance. Vet Parasitol 44:35–44CrossRefPubMed Coles GC, Bauer C, Borgsteede FHM, Geerts S, Walker PJ (1992) World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance. Vet Parasitol 44:35–44CrossRefPubMed
go back to reference Kaemmerer K, Butenkotter S (1973) The problem of residues in meat of edible domestic animals after application or intake of organophosphatic esters. Residue Rev 46:1–240 Kaemmerer K, Butenkotter S (1973) The problem of residues in meat of edible domestic animals after application or intake of organophosphatic esters. Residue Rev 46:1–240
go back to reference Kalesaraj R (1974) Screening of some indeginous plants for anthelmintic action against human Ascaris lumbricoides. Indian J Physiol Pharmacol 19:47–49 Kalesaraj R (1974) Screening of some indeginous plants for anthelmintic action against human Ascaris lumbricoides. Indian J Physiol Pharmacol 19:47–49
go back to reference Kudom AA, Mensah BA, Botchey MA (2011) Aqueous neem extract versus neem powder on Culex quinquefasciatus: implications for control in anthropogenic habitats. J Insect Sci 11:1–9CrossRef Kudom AA, Mensah BA, Botchey MA (2011) Aqueous neem extract versus neem powder on Culex quinquefasciatus: implications for control in anthropogenic habitats. J Insect Sci 11:1–9CrossRef
go back to reference Lal J, Chandra S, Sabir M (1976) In vitro anthelmintic of some indigenous medicinal plants on Ascaridia galli worms. Indian J Physiol Pharmacol 20:64–68PubMed Lal J, Chandra S, Sabir M (1976) In vitro anthelmintic of some indigenous medicinal plants on Ascaridia galli worms. Indian J Physiol Pharmacol 20:64–68PubMed
go back to reference Lavie D, Jain MK, Shpan-Gabrielith SR (1967) A locust phagorepellent from two Melia species. Chem Commun 18:910–911 Lavie D, Jain MK, Shpan-Gabrielith SR (1967) A locust phagorepellent from two Melia species. Chem Commun 18:910–911
go back to reference Maff (1977) Manual of Veterinary Parasitological Laboratory Techniques. Technical Bulletin No. 18, Ministry of Agriculture, Fisheries and Food, London, p 129 Maff (1977) Manual of Veterinary Parasitological Laboratory Techniques. Technical Bulletin No. 18, Ministry of Agriculture, Fisheries and Food, London, p 129
go back to reference Mahboob K, Khan JA, Khan MS (2008) Prevalence, chemotherapy and haematology of stronglyosis in horses of district layyah. J Anim Plant Sci 18:117–119 Mahboob K, Khan JA, Khan MS (2008) Prevalence, chemotherapy and haematology of stronglyosis in horses of district layyah. J Anim Plant Sci 18:117–119
go back to reference Naganishi K (1975) Structure of the insect antifeedant azadirachtin. In: Runeckles VC (ed) Recent advances in phytochemistry, vol 5. Plenum, New York, pp 283–298CrossRef Naganishi K (1975) Structure of the insect antifeedant azadirachtin. In: Runeckles VC (ed) Recent advances in phytochemistry, vol 5. Plenum, New York, pp 283–298CrossRef
go back to reference Neogi NC, Baliga PAC, Shrivastava RK (1964) Anthelmintic activity of some indigenous drugs. Indian J Pharmacol 26:37–39 Neogi NC, Baliga PAC, Shrivastava RK (1964) Anthelmintic activity of some indigenous drugs. Indian J Pharmacol 26:37–39
go back to reference Pietrosemdi S, Olavez R, Montilla T, Campos Z (1999) Empleo de hojas de Neem (Azadirachta indica; A. juss) en control de nematodes gastrointestinales de bovines a pastoreo. Revista de la Facultad de Agronomia 16:220–222 Pietrosemdi S, Olavez R, Montilla T, Campos Z (1999) Empleo de hojas de Neem (Azadirachta indica; A. juss) en control de nematodes gastrointestinales de bovines a pastoreo. Revista de la Facultad de Agronomia 16:220–222
go back to reference Qiao J, Zou X, Lai D, Yan Y, Wang Q, Li W, Deng S, Xu H, Gu H (2013) Azadirachtin blocks the calcium channel and modulates the cholinergic miniature synaptic current in the central nervous system of Drosophila. Pest Manag Sci. doi:10.1002/ps.3644 PubMed Qiao J, Zou X, Lai D, Yan Y, Wang Q, Li W, Deng S, Xu H, Gu H (2013) Azadirachtin blocks the calcium channel and modulates the cholinergic miniature synaptic current in the central nervous system of Drosophila. Pest Manag Sci. doi:10.​1002/​ps.​3644 PubMed
go back to reference Radhakrishnan L, Gomathinayagam Balakrishnan V (2010) Evaluation of anthelmintic effect of Neem (Azadirachta indica) leaves on Haemonchus contortus in goats. Res J Parasitol 5:292–297 Radhakrishnan L, Gomathinayagam Balakrishnan V (2010) Evaluation of anthelmintic effect of Neem (Azadirachta indica) leaves on Haemonchus contortus in goats. Res J Parasitol 5:292–297
go back to reference Rajakaruna RS, Warnakulasooriya KN (2011) Gastrointestinal parasites in dairy cattle in Kandy district in Sri Lanka. Ann Res J SLSAJ 11:92–99 Rajakaruna RS, Warnakulasooriya KN (2011) Gastrointestinal parasites in dairy cattle in Kandy district in Sri Lanka. Ann Res J SLSAJ 11:92–99
go back to reference Ramesh KS, Susan E, Devanand PF (2011) Bioactive constituents and antimicrobial activity of cell cultures of Azadirachta indica. Int J Pharm Bio Sci 2:617–628 Ramesh KS, Susan E, Devanand PF (2011) Bioactive constituents and antimicrobial activity of cell cultures of Azadirachta indica. Int J Pharm Bio Sci 2:617–628
go back to reference Sharma LD, Rhaga HS, Shristava PS (1971) In vitro anthelmintic screening of indigenous medicinal plants against Haemonchus contortus (Rudolphi, 1803) Cobbold., 1898 of sheep and goats. Indian J Anim Res 5:33–38 Sharma LD, Rhaga HS, Shristava PS (1971) In vitro anthelmintic screening of indigenous medicinal plants against Haemonchus contortus (Rudolphi, 1803) Cobbold., 1898 of sheep and goats. Indian J Anim Res 5:33–38
go back to reference Shin-Foon C (1984) The active principles and insecticidal properties of some Chinese plants, with special reference to Meliaceae. In Schmutterer and Asher, pp 255–261 Shin-Foon C (1984) The active principles and insecticidal properties of some Chinese plants, with special reference to Meliaceae. In Schmutterer and Asher, pp 255–261
go back to reference Veerakumari L, Priya P (2006) In vitro effect of azadirachtin on the motility and acetylcholinesterase activity of Cotylophoron cotylophorum (Fischoeder, 1901). J Vet Parasitol 20:1–5 Veerakumari L, Priya P (2006) In vitro effect of azadirachtin on the motility and acetylcholinesterase activity of Cotylophoron cotylophorum (Fischoeder, 1901). J Vet Parasitol 20:1–5
go back to reference Waller PJ (1987) Anthelmintic resistance and future for roundworm control. Vet Parasitol 15:177–191CrossRef Waller PJ (1987) Anthelmintic resistance and future for roundworm control. Vet Parasitol 15:177–191CrossRef
go back to reference Waller PJ, Prichard RK (1985) Drug resistance in nematodes. In: Campbell WC, Rcw RS (eds) Chemotherapy of parasitic infections. Phenum, New York, pp 339–362 Waller PJ, Prichard RK (1985) Drug resistance in nematodes. In: Campbell WC, Rcw RS (eds) Chemotherapy of parasitic infections. Phenum, New York, pp 339–362
Metadata
Title
Anthelmintic efficacy of crude neem (Azadirachta indica) leaf powder against bovine strongylosis
Authors
Nirmala Jamra
Giridhari Das
Priyanka Singh
Manjurul Haque
Publication date
01-12-2015
Publisher
Springer India
Published in
Journal of Parasitic Diseases / Issue 4/2015
Print ISSN: 0971-7196
Electronic ISSN: 0975-0703
DOI
https://doi.org/10.1007/s12639-014-0423-9

Other articles of this Issue 4/2015

Journal of Parasitic Diseases 4/2015 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine