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01-02-2020 | Author's Reply

Answer to the Letter to the Editor of B. Hu et al. concerning “Demographics, presentation and symptoms of patients with Klippel-Feil syndrome: analysis of a global patient-reported registry” by Nouri et al. [Eur Spine J; (2019) 28(10): 2257–2265]

Author: Aria Nouri

Published in: European Spine Journal | Issue 2/2020

Excerpt

Thank you for your interest in our paper. The purpose of our research was to investigate data of patients with KFS, a rare disease, to describe the demographics and identify possible associations with health problems based on the reported data—such an analysis is inherently explorative. While it is true that generally speaking Fisher’s exact test is used when 20% of cells with an expected value of less than 5 are present in a 2 × 2 comparison, this test has also been considered to be conservative [1]. The concern that not having used this test has led to inappropriate conclusions is incorrect. …

Ludbrook J (2008) Analysis of 2 × 2 tables of frequencies: matching test to experimental design. Int J Epidemiol 37:1430–1435PubMedCrossRef

Title: Answer to the Letter to the Editor of B. Hu et al. concerning “Demographics, presentation and symptoms of patients with Klippel-Feil syndrome: analysis of a global patient-reported registry” by Nouri et al. [Eur Spine J; (2019) 28(10): 2257–2265]
Author: Aria Nouri
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 2/2020
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-019-06230-8

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Answer to the Letter to the Editor of B. Hu et al. concerning “Demographics, presentation and symptoms of patients with Klippel-Feil syndrome: analysis of a global patient-reported registry” by Nouri et al. [Eur Spine J; (2019) 28(10): 2257–2265]

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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