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Annals of Nuclear Medicine

08-05-2024 | Positron Emission Tomography | Original Article

Animal PET scanner with a large field of view is suitable for high-throughput scanning of rodents

Authors: Yuki Tomonari, Yuya Onishi, Fumio Hashimoto, Kibo Ote, Takashi Okamoto, Hiroyuki Ohba

Published in: Annals of Nuclear Medicine

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Abstract

Objective

In preclinical studies, high-throughput positron emission tomography (PET) imaging, known as simultaneous multiple animal scanning, can reduce the time spent on animal experiments, the cost of PET tracers, and the risk of synthesis of PET tracers. It is well known that the image quality acquired by high-throughput imaging depends on the PET system. Herein, we investigated the influence of large field of view (FOV) PET scanner on high-throughput imaging.

Methods

We investigated the influence of scanning four objects using a small animal PET scanner with a large FOV. We compared the image quality acquired by four objects scanned with the one acquired by one object scanned using phantoms and animals. We assessed the image quality with uniformity, recovery coefficient (RC), and spillover ratio (SOR), which are indicators of image noise, spatial resolution, and quantitative precision, respectively. For the phantom study, we used the NEMA NU 4-2008 image quality phantom and evaluated uniformity, RC, and SOR, and for the animal study, we used Wistar rats and evaluated the spillover in the heart and kidney.

Results

In the phantom study, four phantoms had little effect on imaging quality, especially SOR compared with that for one phantom. In the animal study as well, four rats had little effect on spillover from the heart muscle and kidney cortex compared with that for one rat.

Conclusions

This study demonstrated that an animal PET scanner with a large FOV was suitable for high-throughput imaging. Thus, the large FOV PET scanner can support drug discovery and bridging research through rapid pharmacological and pathological evaluation.
Appendix
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Metadata
Title
Animal PET scanner with a large field of view is suitable for high-throughput scanning of rodents
Authors
Yuki Tomonari
Yuya Onishi
Fumio Hashimoto
Kibo Ote
Takashi Okamoto
Hiroyuki Ohba
Publication date
08-05-2024
Publisher
Springer Nature Singapore
Published in
Annals of Nuclear Medicine
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-024-01937-1