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Open Access 01-04-2020 | Review article

Animal models of transient ischemic attack: a review

Authors: Jiahui Wang, Ping Zhang, Zhouping Tang

Published in: Acta Neurologica Belgica | Issue 2/2020

Abstract

Transient ischemic attack (TIA) is defined as a brief episode of neurological dysfunction caused by focal cerebral ischemia. TIA is a critical early warning signal of stroke. Patients with TIA may have long-term cognitive decline. The pathogenesis and pathological changes of TIA have not been fully elucidated. Animal models can simulate the process of human diseases and are essential tools to investigate injury mechanisms and therapeutic approaches of TIA. Most TIA animal models are based on ischemic stroke models and the definition of TIA. Each model has unique strengths and weaknesses. The establishment of a successful and reliable TIA model should follow three criteria: (1) objective evidence of cerebral arteries occlusion and reperfusion, (2) no permanent neurological deficit, and (3) no acute cerebral infarction. However, experimental animal models are impossible to be completely consistent with human TIA, because TIA itself is a heterogeneous disease. In the present review, the selection of animals, methodological development, and evaluation of cerebral blood flow of animal models of TIA are comprehensively evaluated.

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Title: Animal models of transient ischemic attack: a review
Authors: Jiahui Wang
Ping Zhang
Zhouping Tang
Publication date: 01-04-2020
Publisher: Springer International Publishing
Published in: Acta Neurologica Belgica / Issue 2/2020
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-020-01295-5

At a glance: The STEP trials

Springer Medicine

Animal models of transient ischemic attack: a review

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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