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Published in: Pediatric Nephrology 11/2013

01-11-2013 | Review

Animal models of nephrotic syndrome

Authors: Ivana Simic, Mansoureh Tabatabaeifar, Franz Schaefer

Published in: Pediatric Nephrology | Issue 11/2013

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Abstract

Animal models of proteinuria and nephrotic syndrome are essential tools for studying the mechanisms of action of abnormalities in individual components of the podocyte and glomerular basement membrane. In recent years a variety of in vivo models have been developed to elucidate the function of specific podocyte proteins and their role in the pathogenesis of proteinuria and glomerulosclerosis. In this overview of the animal models currently available we discuss their contribution to our mechanistic understanding and their potential use in screening for novel targeted therapies of steroid-resistant nephrotic syndrome.
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Metadata
Title
Animal models of nephrotic syndrome
Authors
Ivana Simic
Mansoureh Tabatabaeifar
Franz Schaefer
Publication date
01-11-2013
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 11/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-012-2376-5

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