Published in:
01-04-2003 | Review Article
Animal Models for Therapeutic Embolization
Authors:
Patricia L. Moreira, Yuehuei H. An
Published in:
CardioVascular and Interventional Radiology
|
Issue 2/2003
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Abstract
Embolization techniques have been performed in
different animals to accumulate basic data before a clinical trial.
Choosing the right embolization model for a specific project is
critical. However, there are several variables when defining the best
model for embolization research such as the size of the animal to be
used, the target organs, the route of introducing the embolization
agent, and the feasible methods of evaluation. Commonly used research
animals for endovascular embolization include rabbits, dogs, and rats.
Frequently used target organs are the kidney and the liver. Most models
use a transcatheter for introducing the embolus and occasionally open
surgery and direct arterial injection are used. Basic methods of
evaluation are straightforward, and commonly include macro observation of
the embolized organs, angiogram, and histology. This article concisely
reviews the available animal models and their evaluation for
embolization research to help researchers to choose the appropriate
model.