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Critical Care
Published in: Critical Care 5/2014

Open Access 01-10-2014 | Letter

Anidulafungin dosing during CRRT: do not underestimate adsorption!

Authors: Patrick M Honore, Rita Jacobs, Elisabeth De Waele, Herbert D Spapen

Published in: Critical Care | Issue 5/2014

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Excerpt

Two recent papers in Critical Care discuss the use of echinocandins in general [1], and anidulafungin in particular [2], during continuous renal replacement therapy (CRRT). Being highly protein bound and predominantly nonrenally eliminated drugs, echinocandins are barely removed by convection and thus require no dose adjustment during CRRT. …
Literature
1.
de Molina FJ G, de Los Martínez-Alberici AM, Ferrer R: Treatment with echinocandins during continuous renal replacement therapy. Crit Care. 2014, 18: 218-10.1186/cc13803.CrossRef
2.
Aguilar G, Azanza JR, Sádaba B, Badenes R, Ferrando C, Delgado C, Hernández J, Parra MA, Puig J, Carbonell JA, Navarro D, Belda FJ: Pharmacokinetics of anidulafungin during albumin dialysis. Crit Care. 2014, 18: 422-10.1186/cc13805.CrossRef
3.
Leitner JM, Meyer B, Fuhrmann V, Saria K, Zuba C, Jager W, Bohmdorfer M, Thalhammer F: Multiple-dose pharmacokinetics of anidulafungin during continuous venovenous haemofiltration. J Antimicrob Chemother. 2011, 66: 880-884. 10.1093/jac/dkq545.CrossRef
4.
Honore PM, Jacobs R, Joannes-Boyau O, Boer W, De Waele E, Van Gorp V, Spapen HD: Continuous renal replacement therapy allows higher colistin dosing without increasing toxicity. J Transl Intern Med. 2013, 1: 6-8. 10.4103/2224-4018.124274.CrossRef
5.
Honore PM, Jacobs R, Joannes-Boyau O, De Regt J, De Waele E, van Gorp V, Boer W, Verfaillie L, Spapen HD: Newly designed CRRT membranes for sepsis and SIRS - a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review. ASAIO J. 2013, 59: 99-106. 10.1097/MAT.0b013e3182816a75.CrossRef
Metadata
Title
Anidulafungin dosing during CRRT: do not underestimate adsorption!
Authors
Patrick M Honore
Rita Jacobs
Elisabeth De Waele
Herbert D Spapen
Publication date
01-10-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-014-0618-6

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