Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-10-2021 | Angiography | Neurophthalmology

The retinal vasculature pathophysiological changes in vision recovery after treatment for indirect traumatic optic neuropathy patients

Authors: Yang Gao, Jinmiao Li, Huan Ma, Cong Nie, Xi Lv, Xiaofeng Lin, Guangwei Luo, Jianbo Shi, Rong Lu

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 10/2021

Abstract

Purpose

To evaluate the retinal vasculature pathophysiological changes of indirect traumatic optic neuropathy (ITON) patients after effective surgery.

Methods

Monocular ITON patients who underwent endoscopic trans-ethmosphenoid optic canal decompression (ETOCD) or conservative treatments in Zhongshan Ophthalmic Center from January 2017 to June 2020 were recruited. Visual acuity (VA), visual evoked potential (VEP), oxygen saturation of retinal blood vessels (SO₂), and optical coherence tomography angiography (OCT-A) were measured. All patients were followed up at least 3 months after treatments.

Results

A total of 95 ITON patients were recruited, including 77 patients who underwent ETOCD and 18 patients who underwent conservative treatments. After treatments, more patients received ETOCD (59/77 = 76.6%) presented with improved VA compared with the patients with conservative treatments (6/18 = 33.3%). Compared with the pre-therapeutic measurements, VEP were significantly improved after surgery in ETOCD-treated patients (P < 0.05). Latent periods of P1 and N2, as well as amplitude of P2 of VEP parameters, showed more sensitive to vision recovery (P < 0.05). Retinal artery SO₂ and the differences between arteries and veins were improved in ETOCD-treated patients (P < 0.05). Meanwhile, with OCT-A examination, the retinal thickness and retinal vessel density were notably better in ETOCD-treated patients after surgery than that in patients received conservative treatments (P < 0.05).

Conclusions

Vision recovery after effective treatment of ITON patients was associated with the increased oxygen saturation of retinal vessels, better availability of oxygen in the retina, greater vessel density, and thicker retinas, which might further underlie the vasculature mechanism of vision recovery in ITON patients.

al-Qurainy IA, Stassen LF, Dutton GN et al (1991) The characteristics of midfacial fractures and the association with ocular injury: a prospective study. Br J Oral Maxillofac Surg 29:291–301CrossRef

Anderson RL, Panje WR, Gross CE (1982) Optic nerve blindness following blunt forehead trauma. Ophthalmology 89:445–455CrossRef

Jamal BT, Pfahler SM, Lane KA et al (2009) Ophthalmic injuries in patients with zygomaticomaxillary complex fractures requiring surgical repair. J Oral Maxillofac Surg 67:986–989CrossRef

Steinsapir KD, Goldberg RA (2011) Traumatic optic neuropathy: an evolving understanding. Am J Ophthalmol 151(928–933):e922

Lee AG (2000) Traumatic optic neuropathy. Ophthalmology 107:814CrossRef

Tong J, Kedar S, Ghate D, Gu L (2019) Indirect traumatic optic neuropathy induced by primary blast: a fluid-structure interaction study. J Biomech Eng 10(1115/1):4043668

Yang WG, Chen CT, Tsay PK et al (2004) Outcome for traumatic optic neuropathy–surgical versus nonsurgical treatment. Ann Plast Surg 52:36–42CrossRef

Soldevila L, Cano-Parra J, Ruiz A et al (2013) Traumatic optic neuropathy: to treat or not to treat? Report of two cases. Arch Soc Esp Oftalmol 88:116–119CrossRef

Wang AG (2015) How to manage traumatic optic neuropathy? Taiwan J Ophthalmol 5:1–2CrossRef

10.

Ma YJ, Yu B, Tu YH et al (2018) Prognostic factors of trans-ethmosphenoid optic canal decompression for indirect traumatic optic neuropathy. Int J Ophthalmol 11:1222–1226PubMedPubMedCentral

11.

Yu B, Ma Y, Tu Y, Wu W (2016) The outcome of endoscopic transethmosphenoid optic canal decompression for indirect traumatic optic neuropathy with no-light-perception. J Ophthalmol 2016:6492858PubMedPubMedCentral

12.

Lai IL, Liao HT (2018) Risk factor analysis for the outcomes of indirect traumatic optic neuropathy with no light perception at initial visual acuity testing. World Neurosurg 115:e620–e628CrossRef

13.

Hardarson SH, Harris A, Karlsson RA et al (2006) Automatic retinal oximetry. Invest Ophthalmol Vis Sci 47:5011–5016CrossRef

14.

Shoji T, Zangwill LM, Akagi T et al (2017) Progressive macula vessel density loss in primary open-angle glaucoma: a longitudinal study. Am J Ophthalmol 182:107–117CrossRef

15.

Triolo G, Rabiolo A, Shemonski ND et al (2017) Optical coherence tomography angiography macular and peripapillary vessel perfusion density in healthy subjects, glaucoma suspects, and glaucoma patients. Invest Ophthalmol Vis Sci 58:5713–5722CrossRef

16.

Takusagawa HL, Liu L, Ma KN et al (2017) Projection-resolved optical coherence tomography angiography of macular retinal circulation in glaucoma. Ophthalmology 124:1589–1599CrossRef

17.

de Carlo TE, Bonini Filho MA, Chin AT et al (2015) Spectral-domain optical coherence tomography angiography of choroidal neovascularization. Ophthalmology 122:1228–1238CrossRef

18.

Salz DA, de Carlo TE, Adhi M et al (2016) Select features of diabetic retinopathy on swept-source optical coherence tomographic angiography compared with fluorescein angiography and normal eyes. JAMA Ophthalmol 134:644–650CrossRef

19.

Zhang S, Wu C, Liu L et al (2017) Optical coherence tomography angiography of the peripapillary retina in primary angle-closure glaucoma. Am J Ophthalmol 182:194–200CrossRef

20.

Ling JW, Yin X, Lu QY et al (2017) Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. Int J Ophthalmol 10:1402–1406PubMedPubMedCentral

21.

Zong Y, Lin L, Yi C et al (2016) Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages. Graefes Arch Clin Exp Ophthalmol 254:243–252CrossRef

22.

Li C, Feng X, Wen X et al (2017) Macular retinal vessel oxygen saturation elevation in chinese central serous chorioretinopathy. J Ophthalmol 2017:5972418PubMedPubMedCentral

23.

Augstburger E, Zeboulon P, Keilani C et al (2018) Retinal and choroidal microvasculature in nonarteritic anterior ischemic optic neuropathy: an optical coherence tomography angiography study. Invest Ophthalmol Vis Sci 59:870–877CrossRef

24.

Zhang T, Xiao W, Ye H et al (2019) Peripapillary and macular vessel density in dysthyroid optic neuropathy: an optical coherence tomography angiography study. Invest Ophthalmol Vis Sci 60:1863–1869CrossRef

25.

Yu B, Chen Y, Ma Y et al (2018) Outcome of endoscopic trans-ethmosphenoid optic canal decompression for indirect traumatic optic neuropathy in children. BMC Ophthalmol 18:152CrossRef

26.

Yan W, Lin J, Hu W et al (2020) Combination analysis on the impact of the initial vision and surgical time for the prognosis of indirect traumatic optic neuropathy after endoscopic transnasal optic canal decompression. Neurosurg Rev. https://doi.org/10.1007/s10143-020-01273-8CrossRefPubMed

27.

Huang J, Chen X, Wang Z et al (2020) Selection and prognosis of optic canal decompression for traumatic optic neuropathy. World Neurosurg 138:e564–e578CrossRef

28.

Hardarson SH, Stefansson E (2012) Oxygen saturation in branch retinal vein occlusion. Acta Ophthalmol 90:466–470CrossRef

29.

Zheng Q, Zong Y, Li L et al (2015) Retinal vessel oxygen saturation and vessel diameter in high myopia. Ophthalmic Physiol Opt 35:562–569CrossRef

30.

Cennamo G, Rossi C, Ruggiero P et al (2017) Study of the radial peripapillary capillary network in congenital optic disc anomalies with optical coherence tomography angiography. Am J Ophthalmol 176:1–8CrossRef

31.

Lee JY, Cho K, Park KA, Oh SY (2016) Analysis of retinal layer thicknesses and their clinical correlation in patients with traumatic optic neuropathy. PLoS ONE 11:e0157388CrossRef

Title: The retinal vasculature pathophysiological changes in vision recovery after treatment for indirect traumatic optic neuropathy patients
Authors: Yang Gao
Jinmiao Li
Huan Ma
Cong Nie
Xi Lv
Xiaofeng Lin
Guangwei Luo
Jianbo Shi
Rong Lu
Publication date: 01-10-2021
Publisher: Springer Berlin Heidelberg
Keyword: Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 10/2021
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-021-05208-x

At a glance: The STEP trials

Springer Medicine

The retinal vasculature pathophysiological changes in vision recovery after treatment for indirect traumatic optic neuropathy patients

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 10/2021

Association between HPV detection in swab samples and tissue specimens and ophthalmic pterygium recurrence

Comparison of 1-year surgical outcomes of combined cataract surgery and gonioscopy-assisted transluminal trabeculotomy (GATT) versus cataract surgery and iStent Inject

Differences in the characteristics of subjects achieving complete, partial, or no resolution of macular edema in the READ-3 study

Association of disorganization of retinal inner layers with optical coherence tomography angiography features in branch retinal vein occlusion

Refractive errors after sutureless intrascleral fixation of intraocular lens

Association of retinal detachment with age 50 years or younger at onset in patients with acute retinal necrosis