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23-02-2023 | Angiography | Nephrology - Original Paper

Association of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and acute kidney disease in patients undergoing coronary angiography: a cohort study

Authors: Yihang Ling, Yibo He, Wei Guo, Rongting Zhang, Yukun Zhao, Sijia Yu, Zhidong Huang, Qiang Li, Haozhang Huang, Jin Liu, Yong Liu, Jiyan Chen

Published in: International Urology and Nephrology | Issue 8/2023

Abstract

Background

Acute kidney disease (AKD) following coronary angiography (CAG) indicates a higher risk of chronic kidney disease and follow-up cardiovascular comorbidities. However, the predictive risk factor of AKD is not clear. We sought to verify whether preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP) level was associated with AKD in patients undergoing CAG.

Method

We analyzed 7602 patients underwent CAG in this multi-center registry cohort study. Cardiorenal ImprovemeNt II (CIN-II) in five Chinese tertiary hospitals from 2007 to 2020. The primary outcome was AKD, defined as a ≥ 50% increase of serum creatinine within 7–90 days. Multivariable logistic regressions were used to assess the association between NT-proBNP and AKD.

Result

1009 patients (13.27%) eventually developed AKD, who were more likely to be female, older, and with comorbidities of chronic heart failure and anemia. After adjusting to the potential confounders, the NT-proBNP level remained an independent predictor of AKD (lnNT-proBNP OR: 1.20, 95% CI 1.13–1.28, p < 0.005). Restricted cubic spline analysis demonstrated a linear relationship between elevated NT-proBNP and AKD (p for trend < 0.001). In the subgroup analysis, elevated NT-proBNP level in patients with percutaneous coronary intervention (p for interaction < 0.001) or without previous congestive heart failure (p for interaction = 0.0346) has a more significant value of AKD prediction.

Conclusion

Pre-operative NT-proBNP level was independently associated with the risk of AKD in patients following CAG. Perioperative strategies are warranted to prevent AKD in patients with elevated NT-proBNP levels.

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Title: Association of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and acute kidney disease in patients undergoing coronary angiography: a cohort study
Authors: Yihang Ling
Yibo He
Wei Guo
Rongting Zhang
Yukun Zhao
Sijia Yu
Zhidong Huang
Qiang Li
Haozhang Huang
Jin Liu
Yong Liu
Jiyan Chen
Publication date: 23-02-2023
Publisher: Springer Netherlands
Keywords: Angiography
Heart Failure
Published in: International Urology and Nephrology / Issue 8/2023
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-023-03491-7

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