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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 10-04-2023 | Angiography | Retinal Disorders

Fundus autofluorescence abnormalities can predict fluorescein angiography abnormalities in patients with chronic central serous chorioretinopathy

Authors: Danial Mohabati, Camiel J. F. Boon, Carel B. Hoyng, Konstantine Purtskhvanidze, Johann Roider, Elon H. C. van Dijk

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2023

Abstract

Purpose

This study is to assess the possible correlation between findings on fundus autofluorescence (FAF) and fluorescein angiography (FA) in patients with chronic central serous chorioretinopathy (cCSC).

Methods

This multicentre retrospective cohort study included 71 cCSC patients (92 eyes) with at least 6 months of follow-up, who had a FAF-FA imaging discrepancy larger than 0.5 optic disc diameters in size in the corresponding areas of hyperfluorescent abnormalities. A comparison was performed between progression in size of areas of hyperautofluorescent retinal pigment epithelium (RPE) abnormalities on FAF (HF-FAF) and the hyperfluorescent areas on FA (HF-FA) at first visit and last visit. The possible correlations were estimated between FAF-FA discrepancy and disease characteristics.

Results

The median area of HF-FAF at first visit was 7.48 mm² (1.41–27.9). The median area of HF-FA at first visit and last visit was 2.40 mm² (0.02–17.27) and 5.22 mm² (0.53–25.62), respectively. FAF-FA discrepancy was associated with follow-up duration and the area of HF-FAF at first visit. A mathematical algorithm for grading FAF-FA discrepancy in time was suggested, which predicted the enlargement of hyperfluorescent RPE abnormalities on FA in 82.6% of cases.

Conclusion

There is a statistically significant relationship between the areas of HF-FAF and HF-FA in cCSC patients with FAF-FA imaging discrepancy at first presentation. Long-term changes in RPE alterations in cCSC on FA can be predicted based on baseline HF-FAF and follow-up duration.

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Title: Fundus autofluorescence abnormalities can predict fluorescein angiography abnormalities in patients with chronic central serous chorioretinopathy
Authors: Danial Mohabati
Camiel J. F. Boon
Carel B. Hoyng
Konstantine Purtskhvanidze
Johann Roider
Elon H. C. van Dijk
Publication date: 10-04-2023
Publisher: Springer Berlin Heidelberg
Keyword: Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2023
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-06042-z

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Springer Medicine

Fundus autofluorescence abnormalities can predict fluorescein angiography abnormalities in patients with chronic central serous chorioretinopathy

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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