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Graefe's Archive for Clinical and Experimental Ophthalmology

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13-11-2023 | Angiography | Retinal Disorders

Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion

Authors: Peyman Razavi, Grace Baldwin, Filippos Vingopoulos, Itika Garg, Jack Tracy, Hannah Wescott, Hanna Choi, Rebecca Zeng, Ines Lains, Deeba Husain, Leo A. Kim, Demetrios G. Vavvas, John B. Miller

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2024

Abstract

Purpose

To investigate associations between contrast sensitivity (CS) and vascular metrics on wide-field swept-source optical coherence tomography angiography (WF-SS-OCTA) in patients with retinal vein occlusion (RVO).

Methods

This prospectively recruited, cross-sectional observational study included RVO patients who underwent quantitative CS function (qCSF) testing and WF-SS-OCTA using 3 × 3, 6 × 6, and 12 × 12 mm angiograms on the same day. The study measured several qCSF outcomes and WF-SS-OCTA vascular metrics, including vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ). The data were analyzed using multivariable regression analysis controlling for age and central subfield thickness (CST).

Results

A total of 43 RVO eyes of 43 patients and 30 fellow eyes were included. In RVO eyes, multiple vascular metrics were associated with CS outcomes but not visual acuity (VA). On 12 × 12 images, CS thresholds at 1 cpd, 1.5 cpd, and 3 cpd were significantly associated with VD and VSD, but VA was not. When comparing standardized regression coefficients, we found that vascular metrics had a larger effect size on CS than on VA. For instance, the standardized beta coefficient for FAZ area and CS at 6 cpd (β* = − 0.46, p = 0.007) was larger than logMAR VA (β* = 0.40, p = 0.011).

Conclusion

Microvascular changes on WF-SS-OCTA in RVO had a larger effect size on CS than VA. This suggests CS may better reflect the microvascular changes of RVO compared to VA. qCSF-measured CS might be a valuable adjunct functional metric in evaluating RVO patients.

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Title: Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion
Authors: Peyman Razavi
Grace Baldwin
Filippos Vingopoulos
Itika Garg
Jack Tracy
Hannah Wescott
Hanna Choi
Rebecca Zeng
Ines Lains
Deeba Husain
Leo A. Kim
Demetrios G. Vavvas
John B. Miller
Publication date: 13-11-2023
Publisher: Springer Berlin Heidelberg
Keyword: Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2024
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-06288-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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