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European Radiology

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01-04-2010 | Interventional

Angiographic and artefact-free computed tomography imaging of experimental aneurysms embolised with hydrogel filaments

Authors: Mark R. McCoy, Gregory M. Cruise, Monika Killer

Published in: European Radiology | Issue 4/2010

Abstract

Objectives

We compared experimental rabbit carotid bifurcation aneurysms embolised with platinum coils or hydrogel filaments by using digital subtraction angiography (DSA) and computed tomography angiography (CTA).

Methods

Embolisation was performed using platinum coils (n = 2), hydrogel filaments loaded with iodine (n = 3) and hydrogel filaments loaded with barium sulphate (n = 3). In one case, a stent was deployed in the parent vessel to determine the effect of hydrogel filaments on stent visualisation. DSA evaluations occurred immediately post-treatment. CTA evaluations occurred at 0–13 weeks post-treatment. The DSA and CTA images were evaluated for the lack of artefacts and the visibilities of the embolic mass, individual coils and residual flow in the aneurysm sac and neck.

Results

The DSA results were largely concordant among the three groups. The embolic masses were readily evident with some individual coils being distinguished. In the aneurysms embolised with hydrogel filaments, visualisation of the individual coils, residual flow and stent with minor or no artefacts was possible using CTA. On the other hand, the beam hardening artefacts precluded analysis of aneurysms embolised with platinum coils.

Conclusion

CTA-compatible embolic devices could have wide applications in diverse locations throughout the vasculature, particularly in combination with stents or stent grafts.

Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P (2005) International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 366:809–817CrossRefPubMed

Sluzewski M, Menovsky T, van Rooij WJ, Wijnalda D (2003) Coiling of very large or giant cerebral aneurysms: long-term clinical and serial angiographic results. AJNR Am J Neuroradiol 24:257–262PubMed

Anzalone N, Scomazzoni F, Cirillo M, Righi C, Simionato F, Cadioli M, Iadanza A, Kirchin MA, Scotti G (2008) Follow-up of coiled cerebral aneurysms at 3 T: comparison of 3D time-of-flight MR angiography and contrast-enhanced MR angiography. AJNR Am J Neuroradiol 29:1530–1536CrossRefPubMed

Agid R, Willinsky RA, Lee SK, Terbrugge KG, Farb RI (2008) Characterization of aneurysm remnants after endovascular treatment: contrast-enhanced MR angiography versus catheter digital subtraction angiography. AJNR Am J Neuroradiol 29:1570–1574CrossRefPubMed

Gauvrit JY, Caron S, Taschner CA, Lejeune JP, Pruvo JP, Leclerc X (2008) Intracranial aneurysms treated with Guglielmi detachable coils: long-term imaging follow-up with contrast-enhanced magnetic resonance angiography. J Neurosurg 108:443–449CrossRefPubMed

Wallace RC, Karis JP, Partovi S, Fiorella D (2007) Noninvasive imaging of treated cerebral aneurysms, part I: MR angiographic follow-up of coiled aneurysms. AJNR Am J Neuroradiol 28:1001–1008CrossRefPubMed

Richter G, Engelhorn T, Struffert T, Doelken M, Ganslandt O, Hornegger J, Kalender WA, Doerfler A (2007) Flat panel detector angiographic CT for stent-assisted coil embolization of broad-based cerebral aneurysms. AJNR Am J Neuroradiol 28:1902–1908CrossRefPubMed

Masaryk AM, Frayne R, Unal O, Rappe AH, Strother CM (2000) Utility of CT angiography and MR angiography for the follow-up of experimental aneurysms treated with stents or Guglielmi detachable coils. AJNR Am J Neuroradiol 21:1523–1531PubMed

Valdivia y Alvarado M, Ebrahimi N, Benndorf G (2009) Study of conformability of the new LEO PLUS stent to a curved vascular model using flat-panel detector computed tomography (DynaCT). Neurosurgery 64:130–134; discussion 134PubMed

10.

Dehghani P, Marcuzzi D, Cheema AN (2009) Use of multislice CT coronary angiography to assess degree of left main stent overhang into the aorta. Heart 95:708CrossRefPubMed

11.

Sun Z, Allen YB, Mwipatayi BP, Hartley DE, Lawrence-Brown MM (2008) Multislice CT angiography in the follow-up of fenestrated endovascular grafts: effect of slice thickness on 2D and 3D visualization of the fenestration stents. J Endovasc Ther 15:417–426CrossRefPubMed

12.

Sun Z, Allen YB, Nadkarni S, Knight R, Hartley DE, Lawrence-Brown MM (2008) CT virtual intravascular endoscopy in the visualization of fenestrated stent-grafts. J Endovasc Ther 15:42–51CrossRefPubMed

13.

Wakhloo AK, Deleo MJ 3rd, Brown MM (2009) Advances in interventional neuroradiology. Stroke 40:e305–312CrossRefPubMed

14.

Sedat J, Chau Y, Mondot L, Vargas J, Szapiro J, Lonjon M (2009) Endovascular occlusion of intracranial wide-necked aneurysms with stenting (Neuroform) and coiling: mid-term and long-term results. Neuroradiology 51:401–409CrossRefPubMed

15.

Constant MJ, Keeley EM, Cruise GM (2009) Preparation, characterization, and evaluation of radiopaque hydrogel filaments for endovascular embolization. J Biomed Mater Res B Appl Biomater 89:306–313

16.

Killer M, Kallmes DF, McCoy MR, Ding YH, Shum JC, Cruise GM (2009) Angiographic and histologic comparison of experimental aneurysms embolized with hydrogel filaments. AJNR Am J Neuroradiol. doi:10.3174/ajnr.A1649

17.

Forrest MD, O’Reilly GV (1989) Production of experimental aneurysms at a surgically created arterial bifurcation. AJNR Am J Neuroradiol 10:400–402PubMed

18.

Fiehler J, Byrne JV (2009) Factors affecting outcome after endovascular treatment of intracranial aneurysms. Curr Opin Neurol 22:103–108CrossRefPubMed

19.

Raymond J, Guilbert F, Weill A, Georganos SA, Juravsky L, Lambert A, Lamoureux J, Chagnon M, Roy D (2003) Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke 34:1398–1403CrossRefPubMed

20.

Armerding MD, Rubin GD, Beaulieu CF, Slonim SM, Olcott EW, Samuels SL, Jorgensen MJ, Semba CP, Jeffrey RB Jr, Dake MD (2000) Aortic aneurysmal disease: assessment of stent-graft treatment-CT versus conventional angiography. Radiology 215:138–146PubMed

Title: Angiographic and artefact-free computed tomography imaging of experimental aneurysms embolised with hydrogel filaments
Authors: Mark R. McCoy
Gregory M. Cruise
Monika Killer
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 4/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1604-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Angiographic and artefact-free computed tomography imaging of experimental aneurysms embolised with hydrogel filaments

Abstract

Objectives

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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