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Reproductive Biology and Endocrinology

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Open Access 01-12-2004 | Research

Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens

Authors: Trent D Lund, Daniel J Munson, Herman Adlercreutz, Robert J Handa, Edwin D Lephart

Published in: Reproductive Biology and Endocrinology | Issue 1/2004

Abstract

Background

It is well established that the growth of the prostate gland is a hormone-dependent phenomenon involving both androgenic and estrogenic control. Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate.

Methods

The prostates of male Long-Evans rats fed a diet high in phytoestrogens (Phyto-600) or very low levels of phytoestrogens (Phyto-free) were analyzed to determine the impact of dietary phytoestrogens on prostate weight and androgen receptor (AR) expression in the prostate.

Results

Dietary phytoestrogens significantly decreased post-pubertal prostate weight gain in Phyto-600 vs Phyto-free fed males. Additionally, dietary phytoestrogens (Phyto-600) decreased AR expression in the prostate as determined by in situ hybridization.

Conclusions

Soy phytoestrogens, present in diet, alter prostate growth presumably by binding ER-beta and subsequently reducing AR expression within the prostate.

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Title: Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens
Authors: Trent D Lund
Daniel J Munson
Herman Adlercreutz
Robert J Handa
Edwin D Lephart
Publication date: 01-12-2004
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2004
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/1477-7827-2-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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