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01-12-2010 | Review

Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation

Authors: Jay N. Giedd, Michael Stockman, Catherine Weddle, Maria Liverpool, Aaron Alexander-Bloch, Gregory L. Wallace, Nancy R. Lee, Francois Lalonde, Rhoshel K. Lenroot

Published in: Neuropsychology Review | Issue 4/2010

Abstract

Magnetic resonance imaging studies have begun to map effects of genetic variation on trajectories of brain development. Longitudinal studies of children and adolescents demonstrate a general pattern of childhood peaks of gray matter followed by adolescent declines, functional and structural increases in connectivity and integrative processing, and a changing balance between limbic/subcortical and frontal lobe functions, which extends well into young adulthood. Twin studies have demonstrated that genetic factors are responsible for a significant amount of variation in pediatric brain morphometry. Longitudinal studies have shown specific genetic polymorphisms affect rates of cortical changes associated with maturation. Although over-interpretation and premature application of neuroimaging findings for diagnostic purposes remains a risk, converging data from multiple imaging modalities is beginning to elucidate the influences of genetic factors on brain development and implications of maturational changes for cognition, emotion, and behavior.

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Title: Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation
Authors: Jay N. Giedd
Michael Stockman
Catherine Weddle
Maria Liverpool
Aaron Alexander-Bloch
Gregory L. Wallace
Nancy R. Lee
Francois Lalonde
Rhoshel K. Lenroot
Publication date: 01-12-2010
Publisher: Springer US
Published in: Neuropsychology Review / Issue 4/2010
Print ISSN: 1040-7308
Electronic ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-010-9151-9

At a glance: The STEP trials

Springer Medicine

Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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