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Child's Nervous System
Published in: Child's Nervous System 4/2007

01-04-2007 | Case Report

Anaplastic oligoastrocytoma: previous treatment as a possible cause in a child with acute lymphoblastic leukemia

Authors: Necmettin Tanriover, Mustafa Onur Ulu, Mehmet Sar, Mustafa Uzan

Published in: Child's Nervous System | Issue 4/2007

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Abstract

Introduction

The authors present a 14-year-old patient who developed an anaplastic oligoastrocytoma of the left parietal lobe 9 years after a successful treatment of acute lymphoblastic leukemia (ALL). He had a history of induction chemotherapy, intrathecal methotrexate and prophylactic whole brain irradiation (1,800 cGy in 10 fractions over 2 weeks).

Discussion

Radiation-induced neoplasia is suggested to be the late complication of ALL treatment, and evaluation of large clinical series revealed a relationship between young age at ALL diagnosis (<6 years) and increased high-grade glioma occurrence risk.

Conclusion

The authors have reviewed previously reported cases of secondary central nervous system malignancies focusing on age at ALL diagnosis, and they think that synergistic action of therapeutic modalities could have played a role in the oncogenetic process. Detailed systematic radiological follow-up should be done in these patients especially if a personal history of cranial irradiation is present.
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Metadata
Title
Anaplastic oligoastrocytoma: previous treatment as a possible cause in a child with acute lymphoblastic leukemia
Authors
Necmettin Tanriover
Mustafa Onur Ulu
Mehmet Sar
Mustafa Uzan
Publication date
01-04-2007
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 4/2007
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-006-0246-9

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