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Open Access 01-12-2022 | Anaphylaxis | Case report

Two cases of circulatory collapse due to suspected remimazolam anaphylaxis

Authors: Satoshi Uchida, Daiki Takekawa, Masato Kitayama, Kazuyoshi Hirota

Published in: JA Clinical Reports | Issue 1/2022

Abstract

Background

Remimazolam was approved in Japan in January 2020. We report two cases of circulatory collapse due to suspected remimazolam anaphylaxis during anesthetic induction.

Case presentation

Case 1: A 74-year-old male was scheduled for debridement and skin grafting for a severe burn injury. We induced anesthesia with 4 mg of remimazolam and 20 mg of ketamine. The patient subsequently developed treatment-resistant severe hypotension.

Case 2: A 59-year-old male was scheduled for laparoscopic-assisted sigmoid colectomy. We induced anesthesia with 9 mg of remimazolam. Within a few minutes, the patient developed treatment-resistant severe hypotension.

As serum tryptase was elevated in both cases and only intravenous administration of adrenaline was effective, we considered the circulatory collapse might be due to anaphylaxis.

Conclusion

We experienced two cases of circulatory collapse due to suspected remimazolam anaphylaxis during anesthetic induction. The prevalence of remimazolam anaphylaxis is not yet known, and further research is needed.

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Title: Two cases of circulatory collapse due to suspected remimazolam anaphylaxis
Authors: Satoshi Uchida
Daiki Takekawa
Masato Kitayama
Kazuyoshi Hirota
Publication date: 01-12-2022
Publisher: Springer Berlin Heidelberg
Keywords: Anaphylaxis
Anaphylaxis
Ketamine
Propofol
Wound Debridement
Hypotension
Hypotension
Rocuronium
Published in: JA Clinical Reports / Issue 1/2022
Electronic ISSN: 2363-9024
DOI: https://doi.org/10.1186/s40981-022-00508-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Two cases of circulatory collapse due to suspected remimazolam anaphylaxis

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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