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international journal of stomatology & occlusion medicine
Published in: international journal of stomatology & occlusion medicine 3/2014

01-09-2014 | original article

Analysis of the histopathological features of 54 cases of peripheral giant cell granuloma

A retrospective study

Authors: Matina Zormpa, DDS, MSc, Dimitrios Andreadis, DDS, PhD, Athanasios Poulopoulos, DDS, MSc, PhD, Apostolos Epivatianos, DDS, PhD

Published in: international journal of stomatology & occlusion medicine | Issue 3/2014

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Abstract

Background

Peripheral giant cell granuloma (PGCG) is a common reactive lesion of the gingiva and alveolar ridge. The lesion is characterized by several histopathological features and cellular cannibalism according to the recent literature. The aim of this study was to examine and analytically record the histopathological features of PGCG in an attempt to contribute to a better knowledge of the microscopic characteristics of this lesion.

Methods

Archival sections from 54 cases of PGCG were examined and the histopathological features were recorded.

Results

Cannibalistic type I multinucleated giant cells were found in all cases (100 %). Interstitial hemorrhage and hemosiderin deposits were seen in 92.6 % of the cases. In addition, granules of hemosiderin in type I multinucleated giant cells were occasionally observed. Type I multinucleated giant cells were found in intimate contact with vessels and within the lumen of vessels in 35.1% and 20.3 % of the cases, respectively. Bone was present in 31.5 % of the cases and was most often woven in combination with lamellar bone. Ulcerated (74.1 %) and hyperplastic mucosal lining epithelium (62.2 %) were most often observed. Chronic and both acute and chronic types of inflammatory infiltration and mild intensity of inflammatory infiltration were most often found.

Conclusion

In addition to the common microscopic features the data showed that only type I multinucleated giant cells of PGCGs have cannibalistic behavior, were occasionally involved in phagocytosis of hemosiderin and sometimes entered the lumen of vessels with an as yet unknown mediated process.
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Metadata
Title
Analysis of the histopathological features of 54 cases of peripheral giant cell granuloma
A retrospective study
Authors
Matina Zormpa, DDS, MSc
Dimitrios Andreadis, DDS, PhD
Athanasios Poulopoulos, DDS, MSc, PhD
Apostolos Epivatianos, DDS, PhD
Publication date
01-09-2014
Publisher
Springer Vienna
Published in
international journal of stomatology & occlusion medicine / Issue 3/2014
Print ISSN: 1867-2221
Electronic ISSN: 1867-223X
DOI
https://doi.org/10.1007/s12548-014-0108-0

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