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International Archives of Occupational and Environmental Health

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27-05-2023 | Original Article

Analysis of serum metabolome of laborers exposure to welding fume

Authors: Fangda Peng, Lijia Yu, Chunmin Zhang, Qicai Liu, Kai Yan, Kangfu Zhang, Yuqiao Zheng, Wubin Liu, Yan Li, Jingguang Fan, Chunguang Ding

Published in: International Archives of Occupational and Environmental Health | Issue 7/2023

Abstract

Objective

Welding fume exposure is inevitable of welding workers and poses a severe hazard to their health since welding is a necessary industrial process. Thus, preclinical diagnostic symptoms of worker exposure are of great importance. The aim of this study was to screen serum differential metabolites of welding fume exposure based on UPLC–QTOF-MS/MS.

Methods

In 2019, 49 participants were recruited at a machinery manufacturing factory. The non-target metabolomics technique was used to clarify serum metabolic signatures in people exposed to welding fume. Differential metabolites were screened by OPLS-DA analysis and Student's t-test. The receiver operating characteristic curve evaluated the discriminatory power of differential metabolites. And the correlations between differential metabolites and metal concentrations in urine and whole blood were analyzed utilizing Pearson correlation analysis.

Results

Thirty metabolites were increased significantly, and 5 metabolites were decreased. The differential metabolites are mainly enriched in the metabolism of arachidonic acid, glycero phospholipid, linoleic acid, and thiamine. These results observed that lysophosphatidylcholine (20:1/0:0) and phosphatidylglycerol(PGF1α/16:0) had a tremendous anticipating power with relatively increased AUC values (AUC > 0.9), and they also presented a significant correlation of Mo concentrations in whole blood and Cu concentrations in urine, respectively.

Conclusion

The serum metabolism was changed significantly after exposure to welding fume. Lysophosphatidylcholine (20:1/0:0) and phosphatidylglycerol (PGF1α/16:0) may be a potential biological mediator and biomarker for laborers exposure to welding fume.

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Title: Analysis of serum metabolome of laborers exposure to welding fume
Authors: Fangda Peng
Lijia Yu
Chunmin Zhang
Qicai Liu
Kai Yan
Kangfu Zhang
Yuqiao Zheng
Wubin Liu
Yan Li
Jingguang Fan
Chunguang Ding
Publication date: 27-05-2023
Publisher: Springer Berlin Heidelberg
Published in: International Archives of Occupational and Environmental Health / Issue 7/2023
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-023-01987-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Analysis of serum metabolome of laborers exposure to welding fume

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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