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01-07-2015 | Hepatobiliary Tumors

Analysis of Recurrence Patterns After Anatomical or Non-anatomical Resection for Hepatocellular Carcinoma

Authors: Shigeru Marubashi, MD, PhD, Kunihito Gotoh, MD, PhD, Hirofumi Akita, MD, PhD, Hidenori Takahashi, MD, PhD, Keijiro Sugimura, MD, Norikatsu Miyoshi, MD, PhD, Masaaki Motoori, MD, PhD, Kentaro Kishi, MD, PhD, Shingo Noura, MD, PhD, Yoshiyuki Fujiwara, MD, PhD, Masayuki Ohue, MD, PhD, Tetsuro Nakazawa, MD, PhD, Katsuyuki Nakanishi, MD, PhD, Yuri Ito, PhD, Masahiko Yano, MD, PhD, Osamu Ishikawa, MD, PhD, Masato Sakon, MD, PhD

Published in: Annals of Surgical Oncology | Issue 7/2015

Abstract

Background

Recurrence patterns after hepatic resection has been poorly understood in view of tumor blood flow drainage (TBFD) area. Our goal was to clarify the recurrence patterns after anatomical versus nonanatomical hepatic resection for hepatocellular carcinoma (HCC).

Methods

A total of 424 consecutive patients with HCC, who were treated by curative resection (R0) at our hospital from 2001 to 2012, were evaluated. Among these, we compared the outcomes of the anatomical resection group (AR group, n = 243) and the nonanatomical resection group (NR group, n = 181). We performed an analysis of the recurrence patterns of HCC based on the preoperative CT during hepatic arteriography in these 424 patients.

Results

Preoperative liver function was better in the AR group than the NR group (P < 0.001), and tumor size was larger in the AR group than the NR group (P < 0.001). HCC recurrence was recorded in 145 patients (59.7 %) of the AR group and 102 patients (56.4 %) of the NR group with no significant differences between the two groups (P = 0.590). The incidences of extrahepatic and intrahepatic recurrence (solitary/multiple) were similar between the two groups. In addition, the rate of recurrences by local dissemination, either recurrences in the same subsegment in the NR group or recurrences in the TBFD area in the AR group, was sufficiently low (1.4 %) as to be considered negligible.

Conclusions

The incidence and patterns of HCC recurrence were similar between the anatomical and nonanatomical resection. Recurrence by local dissemination may be considered to be negligible in both surgical methods.

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Title: Analysis of Recurrence Patterns After Anatomical or Non-anatomical Resection for Hepatocellular Carcinoma
Authors: Shigeru Marubashi, MD, PhD
Kunihito Gotoh, MD, PhD
Hirofumi Akita, MD, PhD
Hidenori Takahashi, MD, PhD
Keijiro Sugimura, MD
Norikatsu Miyoshi, MD, PhD
Masaaki Motoori, MD, PhD
Kentaro Kishi, MD, PhD
Shingo Noura, MD, PhD
Yoshiyuki Fujiwara, MD, PhD
Masayuki Ohue, MD, PhD
Tetsuro Nakazawa, MD, PhD
Katsuyuki Nakanishi, MD, PhD
Yuri Ito, PhD
Masahiko Yano, MD, PhD
Osamu Ishikawa, MD, PhD
Masato Sakon, MD, PhD
Publication date: 01-07-2015
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 7/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-014-4214-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Analysis of Recurrence Patterns After Anatomical or Non-anatomical Resection for Hepatocellular Carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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