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01-01-2006 | Case Report

Analysis of chromosomal imbalances in an elderly woman with a giant cell tumour

Authors: Juan Luis García, Cristina Robledo, E. Lumbreras, Teresa Flores, Luis Ramos, Jesús M. Hernández

Published in: Virchows Archiv | Issue 1/2006

Abstract

Giant cell tumour (GCT) remains one of the most obscure and intensely studied bone tumours. In an effort to resolve questions regarding the genesis and clinical outcome of GCT, advances have been made recently in the identification of chromosomal abnormalities implicated in the tumour. Fusion of telomeres is very frequent in GCT, and this process may be associated with chromosome instability and tumour development. However, little emphasis has been placed on chromosomal imbalances in the molecular characterization of this disease. Here, we report the case of an 83-year-old woman diagnosed with GCT where local recurrence was observed after 11 months of the resection. Cytogenetic studies of the GCT showed a modal number of 46 chromosomes with telomeric associations on 11p and dicentric chromosomes. Moreover, clonal abnormalities, such as del(17p) and losses of chromosomes 4, 13 and 18 and gains on chromosome 7, were also detected. Interestingly, comparative genomic hybridisation (CGH) analysis revealed chromosomal imbalances with gains on chromosomes 1p31-q44, 6q12-q23 and 12q15-q22. Thus, the use of CGH expanded the information obtained by conventional cytogenetics and demonstrated that chromosomal imbalances were associated with the recurrence of the GCT.

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Title: Analysis of chromosomal imbalances in an elderly woman with a giant cell tumour
Authors: Juan Luis García
Cristina Robledo
E. Lumbreras
Teresa Flores
Luis Ramos
Jesús M. Hernández
Publication date: 01-01-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 1/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0079-z

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Analysis of chromosomal imbalances in an elderly woman with a giant cell tumour

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