Skip to main content
Top
Published in: Surgery Today 1/2016

01-01-2016 | Original Article

Analysis of anatomical risk factors for persistent type II endoleaks following endovascular abdominal aortic aneurysm repair using CT angiography

Authors: Masayoshi Otsu, Toru Ishizaka, Michiko Watanabe, Takaki Hori, Hiroki Kohno, Keiichi Ishida, Mitsuru Nakaya, Goro Matsumiya

Published in: Surgery Today | Issue 1/2016

Login to get access

Abstract

Purpose

To predict persistent type II endoleaks (pT2Es) following endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms, we examined factors related to post-EVAR pT2Es.

Methods

Eighty-four cases of EVAR were analyzed. T2Es that persisted for ≥6 months were defined as pT2Es. pT2Es flowing from an inferior mesenteric artery (IMA) and lumbar artery (LA) were termed pIMA-T2Es and pLA-T2Es, respectively. The anatomical factors concerning the aneurysm, IMA and LAs were assessed in the preoperative CT angiography images. A statistical analysis was performed on the factors associated with pT2Es.

Results

The incidence of pT2Es was 25 %. pT2Es were associated with postoperative changes in the aneurysm diameter. A univariate analysis showed that a sac thrombus and the number of patent side branches arising from an aneurysm were significant factors associated with pT2Es. The IMA diameters were significantly larger in cases of pIMA-T2Es. The significant factors associated with pLA-T2Es were a circumferential thrombus, the number of patent LAs and the mean LA diameter. Multivariate analyses indicated that a circumferential thrombus was a protective factor for pT2Es, whereas an IMA ≥2.6 mm and each additional LA branch ≥1.9 mm were powerful risk factors for a pT2E.

Conclusion

Significant anatomical factors associated with pT2E were found in this study. These factors may be useful in selecting patients for perioperative intervention.
Literature
1.
go back to reference Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg. 1991;5:491–9.CrossRefPubMed Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg. 1991;5:491–9.CrossRefPubMed
2.
go back to reference Albuquerque FC Jr, Tonnessen BH, Noll RE Jr, Cires G, Kim JK, Sternbergh WC 3rd. Paradigm shifts in the treatment of abdominal aortic aneurysm: trends in 721 patients between 1996 and 2008. J Vasc Surg. 2010;51:1348–52.CrossRefPubMed Albuquerque FC Jr, Tonnessen BH, Noll RE Jr, Cires G, Kim JK, Sternbergh WC 3rd. Paradigm shifts in the treatment of abdominal aortic aneurysm: trends in 721 patients between 1996 and 2008. J Vasc Surg. 2010;51:1348–52.CrossRefPubMed
3.
go back to reference EVAR trial participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet. 2005;365:2179–86.CrossRef EVAR trial participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet. 2005;365:2179–86.CrossRef
4.
go back to reference Lederle FA, Freischlag JA, Kyriakides TC, Padberg FT Jr, Matsumura JS, Kohler TR, et al. Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial. JAMA. 2009;302:1535–42.CrossRefPubMed Lederle FA, Freischlag JA, Kyriakides TC, Padberg FT Jr, Matsumura JS, Kohler TR, et al. Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial. JAMA. 2009;302:1535–42.CrossRefPubMed
5.
go back to reference Prinssen M, Verhoeven EL, Buth J, Cuypers PW, van Sambeek MR, Balm R, et al. A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms. N Engl J Med. 2004;351:1607–18.CrossRefPubMed Prinssen M, Verhoeven EL, Buth J, Cuypers PW, van Sambeek MR, Balm R, et al. A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms. N Engl J Med. 2004;351:1607–18.CrossRefPubMed
6.
go back to reference De Bruin JL, Baas AF, Buth J, Prinssen M, Verhoeven EL, Cuypers PW, et al. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2010;362:1881–9.CrossRefPubMed De Bruin JL, Baas AF, Buth J, Prinssen M, Verhoeven EL, Cuypers PW, et al. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2010;362:1881–9.CrossRefPubMed
7.
go back to reference Becquemin JP, Pillet JC, Lescalie F, Sapoval M, Goueffic Y, Lermusiaux P, et al. A randomized controlled trial of endovascular aneurysm repair versus open surgery for abdominal aortic aneurysms in low- to moderate-risk patients. J Vasc Surg. 2011;53:1167–73.CrossRefPubMed Becquemin JP, Pillet JC, Lescalie F, Sapoval M, Goueffic Y, Lermusiaux P, et al. A randomized controlled trial of endovascular aneurysm repair versus open surgery for abdominal aortic aneurysms in low- to moderate-risk patients. J Vasc Surg. 2011;53:1167–73.CrossRefPubMed
8.
go back to reference Jackson RS, Chang DC, Freischlag JA. Comparison of long-term survival after open vs endovascular repair of intact abdominal aortic aneurysm among Medicare beneficiaries. JAMA. 2012;307:1621–8.CrossRefPubMed Jackson RS, Chang DC, Freischlag JA. Comparison of long-term survival after open vs endovascular repair of intact abdominal aortic aneurysm among Medicare beneficiaries. JAMA. 2012;307:1621–8.CrossRefPubMed
9.
go back to reference Harris PL, Vallabhaneni SR, Desgranges P, Becquemin JP, van Marrewijk C, Laheij RJ. Incidence and risk factors of late rupture, conversion, and death after endovascular repair of infrarenal aortic aneurysms: the EUROSTAR experience. European Collaborators on Stent/graft techniques for aortic aneurysm repair. J Vasc Surg. 2000;32:739–49.CrossRefPubMed Harris PL, Vallabhaneni SR, Desgranges P, Becquemin JP, van Marrewijk C, Laheij RJ. Incidence and risk factors of late rupture, conversion, and death after endovascular repair of infrarenal aortic aneurysms: the EUROSTAR experience. European Collaborators on Stent/graft techniques for aortic aneurysm repair. J Vasc Surg. 2000;32:739–49.CrossRefPubMed
10.
go back to reference van Marrewijk C, Buth J, Harris PL, Norgren L, Nevelsteen A, Wyatt MG. Significance of endoleaks after endovascular repair of abdominal aortic aneurysms: The EUROSTAR experience. J Vasc Surg. 2002;35:461–73.CrossRefPubMed van Marrewijk C, Buth J, Harris PL, Norgren L, Nevelsteen A, Wyatt MG. Significance of endoleaks after endovascular repair of abdominal aortic aneurysms: The EUROSTAR experience. J Vasc Surg. 2002;35:461–73.CrossRefPubMed
11.
go back to reference Jones JE, Atkins MD, Brewster DC, Chung TK, Kwolek CJ, LaMuraglia GM, et al. Persistent type 2 endoleak after endovascular repair of abdominal aortic aneurysm is associated with adverse late outcomes. J Vasc Surg. 2007;46:1–8.CrossRefPubMed Jones JE, Atkins MD, Brewster DC, Chung TK, Kwolek CJ, LaMuraglia GM, et al. Persistent type 2 endoleak after endovascular repair of abdominal aortic aneurysm is associated with adverse late outcomes. J Vasc Surg. 2007;46:1–8.CrossRefPubMed
12.
go back to reference Abularrage CJ, Crawford RS, Conrad MF, Lee H, Kwolek CJ, Brewster DC, et al. Preoperative variables predict persistent type 2 endoleak after endovascular aneurysm repair. J Vasc Surg. 2010;52:19–24.CrossRefPubMed Abularrage CJ, Crawford RS, Conrad MF, Lee H, Kwolek CJ, Brewster DC, et al. Preoperative variables predict persistent type 2 endoleak after endovascular aneurysm repair. J Vasc Surg. 2010;52:19–24.CrossRefPubMed
13.
go back to reference Chuter TA, Faruqi RM, Sawhney R, Reilly LM, Kerlan RB, Canto CJ, et al. Endoleak after endovascular repair of abdominal aortic aneurysm. J Vasc Surg. 2001;34:98–105.CrossRefPubMed Chuter TA, Faruqi RM, Sawhney R, Reilly LM, Kerlan RB, Canto CJ, et al. Endoleak after endovascular repair of abdominal aortic aneurysm. J Vasc Surg. 2001;34:98–105.CrossRefPubMed
14.
go back to reference Silverberg D, Baril DT, Ellozy SH, Carroccio A, Greyrose SE, Lookstein RA, et al. An 8-year experience with type II endoleaks: natural history suggests selective intervention is a safe approach. J Vasc Surg. 2006;44:453–9.CrossRefPubMed Silverberg D, Baril DT, Ellozy SH, Carroccio A, Greyrose SE, Lookstein RA, et al. An 8-year experience with type II endoleaks: natural history suggests selective intervention is a safe approach. J Vasc Surg. 2006;44:453–9.CrossRefPubMed
15.
go back to reference AbuRahma AF, Mousa AY, Campbell JE, Stone PA, Hass SM, Nanjundappa A, et al. The relationship of preoperative thrombus load and location to the development of type II endoleak and sac regression. J Vasc Surg. 2011;53:1534–41.CrossRefPubMed AbuRahma AF, Mousa AY, Campbell JE, Stone PA, Hass SM, Nanjundappa A, et al. The relationship of preoperative thrombus load and location to the development of type II endoleak and sac regression. J Vasc Surg. 2011;53:1534–41.CrossRefPubMed
16.
go back to reference Watanabe M, Ishizaka T, Ishida K, Tamura Y, Matsumiya G. A case of open conversion after EVAR with persistent type II endoleak. Jpn J Vasc Surg. 2013;22:759–63 (in Japanese). Watanabe M, Ishizaka T, Ishida K, Tamura Y, Matsumiya G. A case of open conversion after EVAR with persistent type II endoleak. Jpn J Vasc Surg. 2013;22:759–63 (in Japanese).
17.
go back to reference El Batti S, Cochennec F, Roudot-Thoraval F, Becquemin JP. Type II endoleaks after endovascular repair of abdominal aortic aneurysm are not always a benign condition. J Vasc Surg. 2013;57:1291–7.CrossRefPubMed El Batti S, Cochennec F, Roudot-Thoraval F, Becquemin JP. Type II endoleaks after endovascular repair of abdominal aortic aneurysm are not always a benign condition. J Vasc Surg. 2013;57:1291–7.CrossRefPubMed
18.
go back to reference Nolz R, Teufelsbauer H, Asenbaum U, Beitzke D, Funovics M, Wibmer A, et al. Type II endoleaks after endovascular repair of abdominal aortic aneurysms: fate of the aneurysm sac and neck changes during long-term follow-up. J Endovasc Ther. 2012;19:193–9.CrossRefPubMed Nolz R, Teufelsbauer H, Asenbaum U, Beitzke D, Funovics M, Wibmer A, et al. Type II endoleaks after endovascular repair of abdominal aortic aneurysms: fate of the aneurysm sac and neck changes during long-term follow-up. J Endovasc Ther. 2012;19:193–9.CrossRefPubMed
19.
go back to reference Marchiori A, von Ristow A, Guimaraes M, Schönholz C, Uflacker R. Predictive factors for the development of type II endoleaks. J Endovasc Ther. 2011;18:299–305.CrossRefPubMed Marchiori A, von Ristow A, Guimaraes M, Schönholz C, Uflacker R. Predictive factors for the development of type II endoleaks. J Endovasc Ther. 2011;18:299–305.CrossRefPubMed
20.
go back to reference Rayt HS, Sandford RM, Salem M, Bown MJ, London NJ, Sayers RD. Conservative management of type 2 endoleaks is not associated with increased risk of aneurysm rupture. Eur J Vasc Endovasc Surg. 2009;38:718–23.CrossRefPubMed Rayt HS, Sandford RM, Salem M, Bown MJ, London NJ, Sayers RD. Conservative management of type 2 endoleaks is not associated with increased risk of aneurysm rupture. Eur J Vasc Endovasc Surg. 2009;38:718–23.CrossRefPubMed
21.
go back to reference Steinmetz E, Rubin BG, Sanchez LA, Choi ET, Geraghty PJ, Baty J, et al. Type II endoleak after endovascular abdominal aortic aneurysm repair: a conservative approach with selective intervention is safe and cost-effective. J Vasc Surg. 2004;39:306–13.CrossRefPubMed Steinmetz E, Rubin BG, Sanchez LA, Choi ET, Geraghty PJ, Baty J, et al. Type II endoleak after endovascular abdominal aortic aneurysm repair: a conservative approach with selective intervention is safe and cost-effective. J Vasc Surg. 2004;39:306–13.CrossRefPubMed
22.
go back to reference van Marrewijk CJ, Fransen G, Laheij RJ, Harris PL. Buth J; EUROSTAR Collaborators. Is a type II endoleak after EVAR a harbinger of risk? Causes and outcome of open conversion and aneurysm rupture during follow-up. Eur J Vasc Endovasc Surg. 2004;27:128–37.CrossRefPubMed van Marrewijk CJ, Fransen G, Laheij RJ, Harris PL. Buth J; EUROSTAR Collaborators. Is a type II endoleak after EVAR a harbinger of risk? Causes and outcome of open conversion and aneurysm rupture during follow-up. Eur J Vasc Endovasc Surg. 2004;27:128–37.CrossRefPubMed
23.
go back to reference Ward TJ, Cohen S, Patel RS, Kim E, Fischman AM, Nowakowski FS, et al. Anatomic risk factors for type-2 endoleak following EVAR: a retrospective review of preoperative CT angiography in 326 patients. Cardiovasc Intervent Radiol. 2013. May 24 [Epub ahead of print]. Ward TJ, Cohen S, Patel RS, Kim E, Fischman AM, Nowakowski FS, et al. Anatomic risk factors for type-2 endoleak following EVAR: a retrospective review of preoperative CT angiography in 326 patients. Cardiovasc Intervent Radiol. 2013. May 24 [Epub ahead of print].
24.
go back to reference Sampaio SM, Panneton JM, Mozes GI, Andrews JC, Bower TC, Kalra M, et al. Aneurysm sac thrombus load predicts type II endoleaks after endovascular aneurysm repair. Ann Vasc Surg. 2005;19:302–9.CrossRefPubMed Sampaio SM, Panneton JM, Mozes GI, Andrews JC, Bower TC, Kalra M, et al. Aneurysm sac thrombus load predicts type II endoleaks after endovascular aneurysm repair. Ann Vasc Surg. 2005;19:302–9.CrossRefPubMed
25.
go back to reference Dias NV, Ivancev K, Malina M, Resch T, Lindblad B, Sonesson B. Intra-aneurysm sac pressure measurements after endovascular aneurysm repair: differences between shrinking, unchanged, and expanding aneurysms with and without endoleaks. J Vasc Surg. 2004;39:1229–35.CrossRefPubMed Dias NV, Ivancev K, Malina M, Resch T, Lindblad B, Sonesson B. Intra-aneurysm sac pressure measurements after endovascular aneurysm repair: differences between shrinking, unchanged, and expanding aneurysms with and without endoleaks. J Vasc Surg. 2004;39:1229–35.CrossRefPubMed
26.
go back to reference Ishibashi H, Ishiguchi T, Ohta T, Sugimoto I, Iwata H, Yamada T, et al. Late events and mid-term results after endovascular aneurysm repair. Surg Today. 2014;44:50–4.CrossRefPubMed Ishibashi H, Ishiguchi T, Ohta T, Sugimoto I, Iwata H, Yamada T, et al. Late events and mid-term results after endovascular aneurysm repair. Surg Today. 2014;44:50–4.CrossRefPubMed
27.
go back to reference Chikazawa G, Yoshitaka H, Hiraoka A, Tanaka K, Mouri N, Tamura K, et al. Preoperative coil embolization to aortic branched vessels for prevention of aneurysmal sac enlargement following EVAR: early clinical result. Ann Vasc Dis. 2013;6:175–9.PubMedCentralCrossRefPubMed Chikazawa G, Yoshitaka H, Hiraoka A, Tanaka K, Mouri N, Tamura K, et al. Preoperative coil embolization to aortic branched vessels for prevention of aneurysmal sac enlargement following EVAR: early clinical result. Ann Vasc Dis. 2013;6:175–9.PubMedCentralCrossRefPubMed
28.
go back to reference Axelrod DJ, Lookstein RA, Guller J, Nowakowski FS, Ellozy S, Carroccio A, et al. Inferior mesenteric artery embolization before endovascular aneurysm repair: technique and initial results. J Vasc Interv Radiol. 2004;15:1263–7.CrossRefPubMed Axelrod DJ, Lookstein RA, Guller J, Nowakowski FS, Ellozy S, Carroccio A, et al. Inferior mesenteric artery embolization before endovascular aneurysm repair: technique and initial results. J Vasc Interv Radiol. 2004;15:1263–7.CrossRefPubMed
29.
go back to reference Muthu C, Maani J, Plank LD, Holden A, Hill A. Strategies to reduce the rate of type II endoleaks: routine intraoperative embolization of the inferior mesenteric artery and thrombin injection into the aneurysm sac. J Endovasc Ther. 2007;14:661–8.CrossRefPubMed Muthu C, Maani J, Plank LD, Holden A, Hill A. Strategies to reduce the rate of type II endoleaks: routine intraoperative embolization of the inferior mesenteric artery and thrombin injection into the aneurysm sac. J Endovasc Ther. 2007;14:661–8.CrossRefPubMed
Metadata
Title
Analysis of anatomical risk factors for persistent type II endoleaks following endovascular abdominal aortic aneurysm repair using CT angiography
Authors
Masayoshi Otsu
Toru Ishizaka
Michiko Watanabe
Takaki Hori
Hiroki Kohno
Keiichi Ishida
Mitsuru Nakaya
Goro Matsumiya
Publication date
01-01-2016
Publisher
Springer Japan
Published in
Surgery Today / Issue 1/2016
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-015-1115-5

Other articles of this Issue 1/2016

Surgery Today 1/2016 Go to the issue