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Published in: BMC Emergency Medicine 1/2023

Open Access 01-12-2023 | Analgesics in Dentistry | Research

Application of analgesics in emergency services in Germany: a survey of the medical directors

Authors: Signe Vilcane, Olga Scharonow, Christian Weilbach, Maximilian Scharonow

Published in: BMC Emergency Medicine | Issue 1/2023

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Abstrac

Background

Treatment of acute pain is an essential element of pre-hospital care for injured and critically ill patients. Clinical studies indicate the need for improvement in the prehospital analgesia.

Objective

The aim of this study is to assess the current situation in out of hospital pain management in Germany regarding the substances, indications, dosage and the delegation of the use of analgesics to emergency medical service (EMS) staff.

Material and methods

A standardized survey of the medical directors of the emergency services (MDES) in Germany was carried out using an online questionnaire. The anonymous results were evaluated using the statistical software SPSS (Chi-squared test, Mann-Whitney-U test).

Results

Seventy-seven MDES responsible for 989 rescue stations and 397 EMS- physician bases in 15 federal states took part in this survey. Morphine (98.7%), Fentanyl (85.7%), Piritramide (61%), Sufentanil (18.2%) and Nalbuphine (14,3%) are provided as opioid analgesics. The non-opioid analgesics (NOA) including Ketamine/Esketamine (98,7%), Metamizole (88.3%), Paracetamol (66,2%), Ibuprofen (24,7%) and COX-2-inhibitors (7,8%) are most commonly available. The antispasmodic Butylscopolamine is available (81,8%) to most rescue stations.
Fentanyl is the most commonly provided opioid analgesic for treatment of a traumatic pain (70.1%) and back pain (46.8%), Morphine for visceral colic-like (33.8%) and non-colic pain (53.2%). In cases of acute coronary syndrome is Morphine (85.7%) the leading analgesic substance. Among the non-opioid analgesics is Ketamine/Esketamine (90.9%) most frequently provided to treat traumatic pain, Metamizole for visceral colic-like (70.1%) and non-colic (68.6%) as well as back pain (41.6%). Butylscopolamine is the second most frequently provided medication after Metamizole for “visceral colic-like pain” (55.8%).
EMS staff (with or without a request for presence of the EMS physician on site) are permitted to use the following: Morphine (16.9%), Piritramide (13.0%) and Nalbuphine (10.4%), and of NOAs for (Es)Ketamine (74.1%), Paracetamol (53.3%) and Metamizole (35.1%). The dosages of the most important and commonly provided analgesic substances permitted to independent treatment by the paramedics are often below the recommended range for adults (RDE). The majority of medical directors (78.4%) of the emergency services consider the independent application of analgesics by paramedics sensible. The reason for the relatively rare authorization of opioids for use by paramedics is mainly due to legal (in)certainty (53.2%).

Conclusion

Effective analgesics are available for EMS staff in Germany, the approach to improvement lies in the area of application. For this purpose, the adaptations of the legal framework as well as the creation of a guideline for prehospital analgesia are useful.
Literature
1.
go back to reference Studnek JR, et al. The association between patients’ perception of their overall quality of care and their perception of pain management in the prehospital setting. Prehosp Emerg Care. 2013;17(3):386–91.CrossRefPubMed Studnek JR, et al. The association between patients’ perception of their overall quality of care and their perception of pain management in the prehospital setting. Prehosp Emerg Care. 2013;17(3):386–91.CrossRefPubMed
2.
go back to reference Galinski M, et al. Prevalence and management of acute pain in prehospital emergency medicine. Prehosp Emerg Care. 2010;14(3):334–9.CrossRefPubMed Galinski M, et al. Prevalence and management of acute pain in prehospital emergency medicine. Prehosp Emerg Care. 2010;14(3):334–9.CrossRefPubMed
3.
go back to reference Friesgaard KD, et al. Acute pain in the prehospital setting: a register-based study of 41.241 patients. Scand J Trauma Resusc Emerg Med. 2018;26(1):53.CrossRefPubMedPubMedCentral Friesgaard KD, et al. Acute pain in the prehospital setting: a register-based study of 41.241 patients. Scand J Trauma Resusc Emerg Med. 2018;26(1):53.CrossRefPubMedPubMedCentral
6.
go back to reference Scharonow M, et al. Project for the introduction of prehospital analgesia with fentanyl and morphine administered by specially trained paramedics in a rural service area in Germany. J Pain Res. 2017;10:2595–9.CrossRefPubMedPubMedCentral Scharonow M, et al. Project for the introduction of prehospital analgesia with fentanyl and morphine administered by specially trained paramedics in a rural service area in Germany. J Pain Res. 2017;10:2595–9.CrossRefPubMedPubMedCentral
7.
go back to reference Friesgaard KD, et al. Efficacy and safety of intravenous fentanyl administered by ambulance personnel. Acta Anaesthesiol Scand. 2016;60(4):537–43.CrossRefPubMed Friesgaard KD, et al. Efficacy and safety of intravenous fentanyl administered by ambulance personnel. Acta Anaesthesiol Scand. 2016;60(4):537–43.CrossRefPubMed
8.
go back to reference Schempf B, Casu S, Haske D. Prehospital analgesia by emergency physicians and paramedics: comparison of effectiveness. Anaesthesist. 2017;66(5):325–32.CrossRefPubMed Schempf B, Casu S, Haske D. Prehospital analgesia by emergency physicians and paramedics: comparison of effectiveness. Anaesthesist. 2017;66(5):325–32.CrossRefPubMed
10.
go back to reference Jabourian A, et al. Evaluation of Safety and Efficacy of Prehospital Paramedic Administration of Sub-Dissociative Dose of Ketamine in the Treatment of Trauma-Related Pain in Adult Civilian Population. Cureus. 2020;12(8): e9567.PubMedPubMedCentral Jabourian A, et al. Evaluation of Safety and Efficacy of Prehospital Paramedic Administration of Sub-Dissociative Dose of Ketamine in the Treatment of Trauma-Related Pain in Adult Civilian Population. Cureus. 2020;12(8): e9567.PubMedPubMedCentral
11.
go back to reference Kiavialaitis GE, et al. Clinical practice of pre-hospital analgesia: an observational study of 20,978 missions in Switzerland. Am J Emerg Med. 2020;38(11):2318–23.CrossRefPubMed Kiavialaitis GE, et al. Clinical practice of pre-hospital analgesia: an observational study of 20,978 missions in Switzerland. Am J Emerg Med. 2020;38(11):2318–23.CrossRefPubMed
12.
go back to reference Berben SA, et al. Prevalence and relief of pain in trauma patients in emergency medical services. Clin J Pain. 2011;27(7):587–92.CrossRefPubMed Berben SA, et al. Prevalence and relief of pain in trauma patients in emergency medical services. Clin J Pain. 2011;27(7):587–92.CrossRefPubMed
13.
go back to reference Oberholzer N, et al. Factors influencing quality of pain management in a physician staffed helicopter emergency medical service. Anesth Analg. 2017;125(1):200–9.CrossRefPubMed Oberholzer N, et al. Factors influencing quality of pain management in a physician staffed helicopter emergency medical service. Anesth Analg. 2017;125(1):200–9.CrossRefPubMed
14.
go back to reference Helm M, et al. Oligoanalgesia in patients with an initial Glasgow Coma Scale Score >/=8 in a physician-staffed helicopter emergency medical service: a multicentric secondary data analysis of >100,000 out-of-hospital emergency missions. Anesth Analg. 2020;130(1):176–86.CrossRefPubMed Helm M, et al. Oligoanalgesia in patients with an initial Glasgow Coma Scale Score >/=8 in a physician-staffed helicopter emergency medical service: a multicentric secondary data analysis of >100,000 out-of-hospital emergency missions. Anesth Analg. 2020;130(1):176–86.CrossRefPubMed
15.
go back to reference Hebsgaard S, Mannering A, Zwisler ST. Assessment of acute pain in trauma-A retrospective prehospital evaluation. J Opioid Manag. 2016;12(5):347–53.CrossRefPubMed Hebsgaard S, Mannering A, Zwisler ST. Assessment of acute pain in trauma-A retrospective prehospital evaluation. J Opioid Manag. 2016;12(5):347–53.CrossRefPubMed
16.
go back to reference Hollis GJ, et al. Prehospital ketamine use by paramedics in the Australian Capital Territory: A 12 month retrospective analysis. Emerg Med Australas. 2017;29(1):89–95.CrossRefPubMed Hollis GJ, et al. Prehospital ketamine use by paramedics in the Australian Capital Territory: A 12 month retrospective analysis. Emerg Med Australas. 2017;29(1):89–95.CrossRefPubMed
17.
go back to reference Brokmann JC, et al. Analgesia by telemedically supported paramedics compared with physician-administered analgesia: a prospective, interventional, multicentre trial. Eur J Pain. 2016;20(7):1176–84.CrossRefPubMed Brokmann JC, et al. Analgesia by telemedically supported paramedics compared with physician-administered analgesia: a prospective, interventional, multicentre trial. Eur J Pain. 2016;20(7):1176–84.CrossRefPubMed
18.
go back to reference Lenssen N, et al. Quality of analgesia in physician-operated telemedical prehospital emergency care is comparable to physician-based prehospital care - a retrospective longitudinal study. Sci Rep. 2017;7(1):1536.CrossRefPubMedPubMedCentral Lenssen N, et al. Quality of analgesia in physician-operated telemedical prehospital emergency care is comparable to physician-based prehospital care - a retrospective longitudinal study. Sci Rep. 2017;7(1):1536.CrossRefPubMedPubMedCentral
19.
go back to reference Friesgaard KD, et al. Prehospital intravenous fentanyl administered by ambulance personnel: a cluster-randomised comparison of two treatment protocols. Scand J Trauma Resusc Emerg Med. 2019;27(1):11.CrossRefPubMedPubMedCentral Friesgaard KD, et al. Prehospital intravenous fentanyl administered by ambulance personnel: a cluster-randomised comparison of two treatment protocols. Scand J Trauma Resusc Emerg Med. 2019;27(1):11.CrossRefPubMedPubMedCentral
20.
go back to reference Schaller SJ, et al. Differences in pain treatment between surgeons and anaesthesiologists in a physician staffed prehospital emergency medical service: a retrospective cohort analysis. BMC Anesthesiol. 2019;19(1):18.CrossRefPubMedPubMedCentral Schaller SJ, et al. Differences in pain treatment between surgeons and anaesthesiologists in a physician staffed prehospital emergency medical service: a retrospective cohort analysis. BMC Anesthesiol. 2019;19(1):18.CrossRefPubMedPubMedCentral
21.
go back to reference Sobieraj DM, et al. Comparative effectiveness of analgesics to reduce acute pain in the prehospital setting. Prehosp Emerg Care. 2020;24(2):163–74.CrossRefPubMed Sobieraj DM, et al. Comparative effectiveness of analgesics to reduce acute pain in the prehospital setting. Prehosp Emerg Care. 2020;24(2):163–74.CrossRefPubMed
22.
go back to reference Shackelford SA, et al. Prehospital pain medication use by U.S. Forces in Afghanistan. Mil Med. 2015;180(3):304–9.CrossRefPubMed Shackelford SA, et al. Prehospital pain medication use by U.S. Forces in Afghanistan. Mil Med. 2015;180(3):304–9.CrossRefPubMed
23.
24.
go back to reference McCarthy CP, et al. The on- and off-target effects of morphine in acute coronary syndrome: a narrative review. Am Heart J. 2016;176:114–21.CrossRefPubMed McCarthy CP, et al. The on- and off-target effects of morphine in acute coronary syndrome: a narrative review. Am Heart J. 2016;176:114–21.CrossRefPubMed
25.
go back to reference Ibrahim K, et al. Fentanyl delays the platelet inhibition effects of oral ticagrelor: full report of the PACIFY randomized clinical trial. Thromb Haemost. 2018;118(8):1409–18.CrossRefPubMedPubMedCentral Ibrahim K, et al. Fentanyl delays the platelet inhibition effects of oral ticagrelor: full report of the PACIFY randomized clinical trial. Thromb Haemost. 2018;118(8):1409–18.CrossRefPubMedPubMedCentral
26.
go back to reference Senguttuvan NB, et al. Comparison of the effect of Morphine and Fentanyl in patients with acute coronary syndrome receiving Ticagrelor - The COMET (Comparison Morphine, Fentayl and Ticagrelor) randomized controlled trial. Int J Cardiol. 2021;330:1–6.CrossRefPubMed Senguttuvan NB, et al. Comparison of the effect of Morphine and Fentanyl in patients with acute coronary syndrome receiving Ticagrelor - The COMET (Comparison Morphine, Fentayl and Ticagrelor) randomized controlled trial. Int J Cardiol. 2021;330:1–6.CrossRefPubMed
27.
go back to reference Porter KM, et al. Management of trauma pain in the emergency setting: low-dose methoxyflurane or nitrous oxide? A systematic review and indirect treatment comparison. J Pain Res. 2018;11:11–21.CrossRefPubMed Porter KM, et al. Management of trauma pain in the emergency setting: low-dose methoxyflurane or nitrous oxide? A systematic review and indirect treatment comparison. J Pain Res. 2018;11:11–21.CrossRefPubMed
28.
go back to reference von Vopelius-Feldt J, Wood J, Benger J. Critical care paramedics: where is the evidence? A systematic review. Emerg Med J. 2014;31(12):1016–24.CrossRef von Vopelius-Feldt J, Wood J, Benger J. Critical care paramedics: where is the evidence? A systematic review. Emerg Med J. 2014;31(12):1016–24.CrossRef
29.
go back to reference Kill, C., Greb, I., Wranze, E. et al. , Kompetenzentwicklung im Rettungsdienst. Notfall Rettungsmed 04/2007. Kill, C., Greb, I., Wranze, E. et al. , Kompetenzentwicklung im Rettungsdienst. Notfall Rettungsmed 04/2007.
30.
go back to reference I. Greb, E.W., H. Hartmann, H. Wulf, C. Kill, Analgesie beim Extremitätentrauma durch Rettungsfachpersonal. Daten zu Sicherheit und Wirksamkeit bei präklinischer Morphingabe. Notfall Rettungsmed, 02/2011. I. Greb, E.W., H. Hartmann, H. Wulf, C. Kill, Analgesie beim Extremitätentrauma durch Rettungsfachpersonal. Daten zu Sicherheit und Wirksamkeit bei präklinischer Morphingabe. Notfall Rettungsmed, 02/2011.
31.
go back to reference Haske D, et al. Prehospital analgesia performed by paramedics: quality in processes and effects under medical supervision. Anaesthesist. 2014;63(3):209–16.PubMed Haske D, et al. Prehospital analgesia performed by paramedics: quality in processes and effects under medical supervision. Anaesthesist. 2014;63(3):209–16.PubMed
32.
go back to reference Flemming A, Adams HA. Analgesia, sedation and anaesthesia in emergency service. Anaesthesiol Reanim. 2004;29(2):40–8.PubMed Flemming A, Adams HA. Analgesia, sedation and anaesthesia in emergency service. Anaesthesiol Reanim. 2004;29(2):40–8.PubMed
33.
go back to reference Gnirke A, et al. Analgesia in the emergency medical service: comparison between tele-emergency physician and call back procedure with respect to application safety, effectiveness and tolerance. Anaesthesist. 2019;68(10):665–75.CrossRefPubMed Gnirke A, et al. Analgesia in the emergency medical service: comparison between tele-emergency physician and call back procedure with respect to application safety, effectiveness and tolerance. Anaesthesist. 2019;68(10):665–75.CrossRefPubMed
Metadata
Title
Application of analgesics in emergency services in Germany: a survey of the medical directors
Authors
Signe Vilcane
Olga Scharonow
Christian Weilbach
Maximilian Scharonow
Publication date
01-12-2023

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